Ibuprofen: Original Versus Green Synthesis
This paper makes a parallel between the original route versus the green route of Ibuprofen (non-steroidal anti-inflammatory drugs most commonly recommended) synthesis. The original route contained six steps with stoichiometric reagents (some reagents are very toxic: hydrochloric acid, ammonia), a lo...
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| Format: | Article |
| Language: | English |
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Galati University Press
2018-09-01
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| Series: | The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science |
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| Online Access: | https://www.gup.ugal.ro/ugaljournals/index.php/mms/article/view/1757 |
| _version_ | 1818888050614206464 |
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| author | Alina Crina MUREŞAN |
| author_facet | Alina Crina MUREŞAN |
| author_sort | Alina Crina MUREŞAN |
| collection | DOAJ |
| description | This paper makes a parallel between the original route versus the green route of Ibuprofen (non-steroidal anti-inflammatory drugs most commonly recommended) synthesis. The original route contained six steps with stoichiometric reagents (some reagents are very toxic: hydrochloric acid, ammonia), a lot of intermediate products, relatively low atom efficiency equal to 40.04% and substantial inorganic salt formation (aluminium trichloride hydrate). The green route of Ibuprofen synthesis developed only three steps, a lower amount of waste and by-products (only acetic acid that can be used for another applications) and an atom efficiency of 77.44%. The green route for Ibuprofen synthesis is an exquisite example of a simple and elegant chemical/pharmaceutical manufacturing process and the nearly complete atom utilization of this streamlined process truly makes it a wasteminimizing, environmentally friendly technology. |
| first_indexed | 2024-12-19T16:46:58Z |
| format | Article |
| id | doaj.art-e4ac8eee47d746c3a12a2776fb3a4703 |
| institution | Directory Open Access Journal |
| issn | 2668-4748 2668-4756 |
| language | English |
| last_indexed | 2024-12-19T16:46:58Z |
| publishDate | 2018-09-01 |
| publisher | Galati University Press |
| record_format | Article |
| series | The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science |
| spelling | doaj.art-e4ac8eee47d746c3a12a2776fb3a47032022-12-21T20:13:38ZengGalati University PressThe Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science2668-47482668-47562018-09-0141310.35219/mms.2018.3.05Ibuprofen: Original Versus Green SynthesisAlina Crina MUREŞAN0"Dunarea de Jos" University of Galati, RomaniaThis paper makes a parallel between the original route versus the green route of Ibuprofen (non-steroidal anti-inflammatory drugs most commonly recommended) synthesis. The original route contained six steps with stoichiometric reagents (some reagents are very toxic: hydrochloric acid, ammonia), a lot of intermediate products, relatively low atom efficiency equal to 40.04% and substantial inorganic salt formation (aluminium trichloride hydrate). The green route of Ibuprofen synthesis developed only three steps, a lower amount of waste and by-products (only acetic acid that can be used for another applications) and an atom efficiency of 77.44%. The green route for Ibuprofen synthesis is an exquisite example of a simple and elegant chemical/pharmaceutical manufacturing process and the nearly complete atom utilization of this streamlined process truly makes it a wasteminimizing, environmentally friendly technology.https://www.gup.ugal.ro/ugaljournals/index.php/mms/article/view/1757Ibuprofengreen synthesisatom economyenvironmentally friendly |
| spellingShingle | Alina Crina MUREŞAN Ibuprofen: Original Versus Green Synthesis The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science Ibuprofen green synthesis atom economy environmentally friendly |
| title | Ibuprofen: Original Versus Green Synthesis |
| title_full | Ibuprofen: Original Versus Green Synthesis |
| title_fullStr | Ibuprofen: Original Versus Green Synthesis |
| title_full_unstemmed | Ibuprofen: Original Versus Green Synthesis |
| title_short | Ibuprofen: Original Versus Green Synthesis |
| title_sort | ibuprofen original versus green synthesis |
| topic | Ibuprofen green synthesis atom economy environmentally friendly |
| url | https://www.gup.ugal.ro/ugaljournals/index.php/mms/article/view/1757 |
| work_keys_str_mv | AT alinacrinamuresan ibuprofenoriginalversusgreensynthesis |