Mesenchymal Stem Cell Migration and Tissue Repair
Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, which play key roles in tissue healing and regenerative medicine. Bone marrow-derived mesenchymal stem cells (BMSCs) are the most frequently used stem cells in cell the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/8/784 |
| _version_ | 1797713656528502784 |
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| author | Xiaorong Fu Ge Liu Alexander Halim Yang Ju Qing Luo Guanbin Song |
| author_facet | Xiaorong Fu Ge Liu Alexander Halim Yang Ju Qing Luo Guanbin Song |
| author_sort | Xiaorong Fu |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, which play key roles in tissue healing and regenerative medicine. Bone marrow-derived mesenchymal stem cells (BMSCs) are the most frequently used stem cells in cell therapy and tissue engineering. However, it is prerequisite for BMSCs to mobilize from bone marrow and migrate into injured tissues during the healing process, through peripheral circulation. The migration of BMSCs is regulated by mechanical and chemical factors in this trafficking process. In this paper, we review the effects of several main regulatory factors on BMSC migration and its underlying mechanism; discuss two critical roles of BMSCs—namely, directed differentiation and the paracrine function—in tissue repair; and provide insight into the relationship between BMSC migration and tissue repair, which may provide a better guide for clinical applications in tissue repair through the efficient regulation of BMSC migration. |
| first_indexed | 2024-03-12T07:39:57Z |
| format | Article |
| id | doaj.art-e4ad08b101994d8eb34093c28e70076e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:39:57Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e4ad08b101994d8eb34093c28e70076e2023-09-02T21:23:12ZengMDPI AGCells2073-44092019-07-018878410.3390/cells8080784cells8080784Mesenchymal Stem Cell Migration and Tissue RepairXiaorong Fu0Ge Liu1Alexander Halim2Yang Ju3Qing Luo4Guanbin Song5College of Bioengineering, Chongqing University, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing 400030, ChinaCollege of Bioengineering, Chongqing University, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing 400030, ChinaCollege of Bioengineering, Chongqing University, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing 400030, ChinaDepartment of Mechanical Science and Engineering, Nagoya University, Nagoya 464-8603, JapanCollege of Bioengineering, Chongqing University, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing 400030, ChinaCollege of Bioengineering, Chongqing University, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing 400030, ChinaMesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, which play key roles in tissue healing and regenerative medicine. Bone marrow-derived mesenchymal stem cells (BMSCs) are the most frequently used stem cells in cell therapy and tissue engineering. However, it is prerequisite for BMSCs to mobilize from bone marrow and migrate into injured tissues during the healing process, through peripheral circulation. The migration of BMSCs is regulated by mechanical and chemical factors in this trafficking process. In this paper, we review the effects of several main regulatory factors on BMSC migration and its underlying mechanism; discuss two critical roles of BMSCs—namely, directed differentiation and the paracrine function—in tissue repair; and provide insight into the relationship between BMSC migration and tissue repair, which may provide a better guide for clinical applications in tissue repair through the efficient regulation of BMSC migration.https://www.mdpi.com/2073-4409/8/8/784mesenchymal stem cellsmigrationdifferentiationparacrinetissue repairmechanochemical regulation |
| spellingShingle | Xiaorong Fu Ge Liu Alexander Halim Yang Ju Qing Luo Guanbin Song Mesenchymal Stem Cell Migration and Tissue Repair Cells mesenchymal stem cells migration differentiation paracrine tissue repair mechanochemical regulation |
| title | Mesenchymal Stem Cell Migration and Tissue Repair |
| title_full | Mesenchymal Stem Cell Migration and Tissue Repair |
| title_fullStr | Mesenchymal Stem Cell Migration and Tissue Repair |
| title_full_unstemmed | Mesenchymal Stem Cell Migration and Tissue Repair |
| title_short | Mesenchymal Stem Cell Migration and Tissue Repair |
| title_sort | mesenchymal stem cell migration and tissue repair |
| topic | mesenchymal stem cells migration differentiation paracrine tissue repair mechanochemical regulation |
| url | https://www.mdpi.com/2073-4409/8/8/784 |
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