Windows of opportunity for Ebola virus infection treatment and vaccination
Abstract Ebola virus (EBOV) infection causes a high death toll, killing a high proportion of EBOV-infected patients within 7 days. Comprehensive data on EBOV infection are fragmented, hampering efforts in developing therapeutics and vaccines against EBOV. Under this circumstance, mathematical models...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-08884-0 |
| _version_ | 1818839829867134976 |
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| author | Van Kinh Nguyen Esteban A. Hernandez-Vargas |
| author_facet | Van Kinh Nguyen Esteban A. Hernandez-Vargas |
| author_sort | Van Kinh Nguyen |
| collection | DOAJ |
| description | Abstract Ebola virus (EBOV) infection causes a high death toll, killing a high proportion of EBOV-infected patients within 7 days. Comprehensive data on EBOV infection are fragmented, hampering efforts in developing therapeutics and vaccines against EBOV. Under this circumstance, mathematical models become valuable resources to explore potential controlling strategies. In this paper, we employed experimental data of EBOV-infected nonhuman primates (NHPs) to construct a mathematical framework for determining windows of opportunity for treatment and vaccination. Considering a prophylactic vaccine based on recombinant vesicular stomatitis virus expressing the EBOV glycoprotein (rVSV-EBOV), vaccination could be protective if a subject is vaccinated during a period from one week to four months before infection. For the case of a therapeutic vaccine based on monoclonal antibodies (mAbs), a single dose might resolve the invasive EBOV replication even if it was administrated as late as four days after infection. Our mathematical models can be used as building blocks for evaluating therapeutic and vaccine modalities as well as for evaluating public health intervention strategies in outbreaks. Future laboratory experiments will help to validate and refine the estimates of the windows of opportunity proposed here. |
| first_indexed | 2024-12-19T04:00:31Z |
| format | Article |
| id | doaj.art-e4ad7b11c75e48b687ec741e244a95fe |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T04:00:31Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e4ad7b11c75e48b687ec741e244a95fe2022-12-21T20:36:41ZengNature PortfolioScientific Reports2045-23222017-08-017111010.1038/s41598-017-08884-0Windows of opportunity for Ebola virus infection treatment and vaccinationVan Kinh Nguyen0Esteban A. Hernandez-Vargas1Frankfurt Institute for Advanced StudiesFrankfurt Institute for Advanced StudiesAbstract Ebola virus (EBOV) infection causes a high death toll, killing a high proportion of EBOV-infected patients within 7 days. Comprehensive data on EBOV infection are fragmented, hampering efforts in developing therapeutics and vaccines against EBOV. Under this circumstance, mathematical models become valuable resources to explore potential controlling strategies. In this paper, we employed experimental data of EBOV-infected nonhuman primates (NHPs) to construct a mathematical framework for determining windows of opportunity for treatment and vaccination. Considering a prophylactic vaccine based on recombinant vesicular stomatitis virus expressing the EBOV glycoprotein (rVSV-EBOV), vaccination could be protective if a subject is vaccinated during a period from one week to four months before infection. For the case of a therapeutic vaccine based on monoclonal antibodies (mAbs), a single dose might resolve the invasive EBOV replication even if it was administrated as late as four days after infection. Our mathematical models can be used as building blocks for evaluating therapeutic and vaccine modalities as well as for evaluating public health intervention strategies in outbreaks. Future laboratory experiments will help to validate and refine the estimates of the windows of opportunity proposed here.https://doi.org/10.1038/s41598-017-08884-0 |
| spellingShingle | Van Kinh Nguyen Esteban A. Hernandez-Vargas Windows of opportunity for Ebola virus infection treatment and vaccination Scientific Reports |
| title | Windows of opportunity for Ebola virus infection treatment and vaccination |
| title_full | Windows of opportunity for Ebola virus infection treatment and vaccination |
| title_fullStr | Windows of opportunity for Ebola virus infection treatment and vaccination |
| title_full_unstemmed | Windows of opportunity for Ebola virus infection treatment and vaccination |
| title_short | Windows of opportunity for Ebola virus infection treatment and vaccination |
| title_sort | windows of opportunity for ebola virus infection treatment and vaccination |
| url | https://doi.org/10.1038/s41598-017-08884-0 |
| work_keys_str_mv | AT vankinhnguyen windowsofopportunityforebolavirusinfectiontreatmentandvaccination AT estebanahernandezvargas windowsofopportunityforebolavirusinfectiontreatmentandvaccination |