Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling

Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling

PTP1B and TC-PTP are highly related protein-tyrosine phosphatases (PTPs) that regulate the JAK/STAT signaling cascade essential for cytokine-receptor activation in immune cells. Here, we describe a novel immunotherapy approach whereby monocyte-derived dendritic cell (moDC) function is enhanced by mo...

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Bibliographic Details
Main Authors: Claudia Penafuerte, Matthew Feldhammer, John R. Mills, Valerie Vinette, Kelly A. Pike, Anita Hall, Eva Migon, Gerard Karsenty, Jerry Pelletier, George Zogopoulos, Michel L. Tremblay
Format: Article
Language:English
Published: Taylor & Francis Group 2017-06-01
Series:OncoImmunology
Subjects:
dendritic cells (dcs)
immunotherapy
protein-tyrosine phosphatases
ptp1b
tc-ptp
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1321185

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