Clostridioides Infection in Patients with Inflammatory Bowel Disease
Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is a chronic inflammatory condition of the gastrointestinal tract, which is often accompanied by altered gut microbial composition. Gut dysbiosis in IBD is considered to be the reason for the high risk of Clostridio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Jin Publishing & Printing Co.
2022-08-01
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| Series: | The Korean Journal of Gastroenterology |
| Subjects: | |
| Online Access: | https://www.kjg.or.kr/journal/view.html?uid=5842&vmd=Full |
| _version_ | 1827325461677473792 |
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| author | Mi Rae Lee Eun Soo Kim |
| author_facet | Mi Rae Lee Eun Soo Kim |
| author_sort | Mi Rae Lee |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is a chronic inflammatory condition of the gastrointestinal tract, which is often accompanied by altered gut microbial composition. Gut dysbiosis in IBD is considered to be the reason for the high risk of Clostridioides difficile infection (CDI) in patients with IBD. Therefore, CDI should be evaluated in IBD patients with a symptom flare. Medical treatment of non-severe CDI in IBD is similar to that in non-IBD patients and includes oral vancomycin or fidaxomicin. The risk of recurrent CDI in IBD is higher than in non-IBD patients and this could be mitigated by fecal microbiota transplantation. As CDI may worsen the clinical outcomes of IBD, patients should be carefully monitored and an escalation of IBD therapy needs to be considered when there is no improvement seen with the antimicrobial treatment of CDI. This review discusses the risk, pathophysiology, diagnosis, and management of CDI in IBD. |
| first_indexed | 2024-03-07T14:27:33Z |
| format | Article |
| id | doaj.art-e4af1da639be426aaab38f0644eb6eb8 |
| institution | Directory Open Access Journal |
| issn | 1598-9992 2233-6869 |
| language | English |
| last_indexed | 2024-03-07T14:27:33Z |
| publishDate | 2022-08-01 |
| publisher | Jin Publishing & Printing Co. |
| record_format | Article |
| series | The Korean Journal of Gastroenterology |
| spelling | doaj.art-e4af1da639be426aaab38f0644eb6eb82024-03-06T06:36:11ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922233-68692022-08-01802667110.4166/kjg.2022.097Clostridioides Infection in Patients with Inflammatory Bowel DiseaseMi Rae Lee0Eun Soo Kim1https://orcid.org/0000-0003-0806-9136Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, KoreaDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, KoreaInflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is a chronic inflammatory condition of the gastrointestinal tract, which is often accompanied by altered gut microbial composition. Gut dysbiosis in IBD is considered to be the reason for the high risk of Clostridioides difficile infection (CDI) in patients with IBD. Therefore, CDI should be evaluated in IBD patients with a symptom flare. Medical treatment of non-severe CDI in IBD is similar to that in non-IBD patients and includes oral vancomycin or fidaxomicin. The risk of recurrent CDI in IBD is higher than in non-IBD patients and this could be mitigated by fecal microbiota transplantation. As CDI may worsen the clinical outcomes of IBD, patients should be carefully monitored and an escalation of IBD therapy needs to be considered when there is no improvement seen with the antimicrobial treatment of CDI. This review discusses the risk, pathophysiology, diagnosis, and management of CDI in IBD.https://www.kjg.or.kr/journal/view.html?uid=5842&vmd=Fullclostridioides difficile infectioninflammatory bowel diseasescolitisulcerativecrohn disease |
| spellingShingle | Mi Rae Lee Eun Soo Kim Clostridioides Infection in Patients with Inflammatory Bowel Disease The Korean Journal of Gastroenterology clostridioides difficile infection inflammatory bowel diseases colitis ulcerative crohn disease |
| title | Clostridioides Infection in Patients with Inflammatory Bowel Disease |
| title_full | Clostridioides Infection in Patients with Inflammatory Bowel Disease |
| title_fullStr | Clostridioides Infection in Patients with Inflammatory Bowel Disease |
| title_full_unstemmed | Clostridioides Infection in Patients with Inflammatory Bowel Disease |
| title_short | Clostridioides Infection in Patients with Inflammatory Bowel Disease |
| title_sort | clostridioides infection in patients with inflammatory bowel disease |
| topic | clostridioides difficile infection inflammatory bowel diseases colitis ulcerative crohn disease |
| url | https://www.kjg.or.kr/journal/view.html?uid=5842&vmd=Full |
| work_keys_str_mv | AT miraelee clostridioidesinfectioninpatientswithinflammatoryboweldisease AT eunsookim clostridioidesinfectioninpatientswithinflammatoryboweldisease |