Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape

Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape

Current capabilities in genomic sequencing outpace functional interpretations. Our previous work showed that 3D protein structure calculations enhance mechanistic understanding of genetic variation in sequenced tumors and patients with rare diseases. The KRAS GTPase is among the critical genetic fac...

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Bibliographic Details
Main Authors: Brian D. Ratnasinghe, Neshatul Haque, Jessica B. Wagenknecht, Davin R. Jensen, Guadalupe K. Valdivia Esparza, Elise N. Leverence, Thiago Milech De Assuncao, Angela J. Mathison, Gwen Lomberk, Brian C. Smith, Brian F. Volkman, Raul Urrutia, Michael T. Zimmermann
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Molecular dynamics
KRAS
Genomics
Cancer
Rare disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023003598

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http://www.sciencedirect.com/science/article/pii/S2001037023003598

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