MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE)
This review discusses the data of new researches on the functional purpose of sleep and its stages, and its role in the development of pathological conditions. The main modern hypotheses and concepts about a role of slow sleep and REM-sleep (rapid eye movement) are interpreted. The visceral theory o...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2017-07-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/411 |
| _version_ | 1797237372206710784 |
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| author | I. M. Madaeva O. N. Berdina |
| author_facet | I. M. Madaeva O. N. Berdina |
| author_sort | I. M. Madaeva |
| collection | DOAJ |
| description | This review discusses the data of new researches on the functional purpose of sleep and its stages, and its role in the development of pathological conditions. The main modern hypotheses and concepts about a role of slow sleep and REM-sleep (rapid eye movement) are interpreted. The visceral theory of slow sleep as an activator of restorative processes in the brain and manager of internal organs functions is described. A brain "drainage" function of slow sleep is known. Recent studies suggest sleep-wake disturbances, for example, obstructive apnea syndrome, may influence Alzheimer's disease (AD) onset and progression. Possible mechanisms such asfunctional disorders of brain lymphatic system during slow sleep and the extracellular accumulation of the amyloid-ß (Aß) peptide underlying the relationship between the sleep-wake disturbances and AD are described. The role of REM-sleep in the formation of the central nervous system in the early postnatal period and the performance of the function of mental adaptation are discussed. In this article, we presented data about the role both of neurotransmitters and neuropeptides in the regulation of sleep-wake cycle and the maintenance of wakefulness and REM-sleep. The possible new approach to the forecasting of cognitive and emotional-affective disorders in sleep disturbances is substantiated from the perspective of modern neuroscience and sleep neurophysiology still in childhood is justified. |
| first_indexed | 2024-03-08T12:18:26Z |
| format | Article |
| id | doaj.art-e4b13be1b6554555bc34bd8a0dfcb063 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:18:42Z |
| publishDate | 2017-07-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-e4b13be1b6554555bc34bd8a0dfcb0632024-03-28T07:49:18ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962017-07-0124485210.12737/article_59fad513a63772.41901536411MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE)I. M. Madaeva0O. N. Berdina1Scientific Centre for Family Health and Human Reproduction ProblemsScientific Centre for Family Health and Human Reproduction ProblemsThis review discusses the data of new researches on the functional purpose of sleep and its stages, and its role in the development of pathological conditions. The main modern hypotheses and concepts about a role of slow sleep and REM-sleep (rapid eye movement) are interpreted. The visceral theory of slow sleep as an activator of restorative processes in the brain and manager of internal organs functions is described. A brain "drainage" function of slow sleep is known. Recent studies suggest sleep-wake disturbances, for example, obstructive apnea syndrome, may influence Alzheimer's disease (AD) onset and progression. Possible mechanisms such asfunctional disorders of brain lymphatic system during slow sleep and the extracellular accumulation of the amyloid-ß (Aß) peptide underlying the relationship between the sleep-wake disturbances and AD are described. The role of REM-sleep in the formation of the central nervous system in the early postnatal period and the performance of the function of mental adaptation are discussed. In this article, we presented data about the role both of neurotransmitters and neuropeptides in the regulation of sleep-wake cycle and the maintenance of wakefulness and REM-sleep. The possible new approach to the forecasting of cognitive and emotional-affective disorders in sleep disturbances is substantiated from the perspective of modern neuroscience and sleep neurophysiology still in childhood is justified.https://www.actabiomedica.ru/jour/article/view/411«медленный сон»«быстрый сон»b-амилоидsleep-wake cycleslow sleeprem-sleeprestoring sleep functionhypothesis of “drainage” sleep functionamyloid-b peptidealzheimer’s disease |
| spellingShingle | I. M. Madaeva O. N. Berdina MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE) Acta Biomedica Scientifica «медленный сон» «быстрый сон» b-амилоид sleep-wake cycle slow sleep rem-sleep restoring sleep function hypothesis of “drainage” sleep function amyloid-b peptide alzheimer’s disease |
| title | MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE) |
| title_full | MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE) |
| title_fullStr | MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE) |
| title_full_unstemmed | MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE) |
| title_short | MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE) |
| title_sort | modern ideas of slow sleep and rem sleep and their role in pathogenesis of alzheimer s disease review of literature |
| topic | «медленный сон» «быстрый сон» b-амилоид sleep-wake cycle slow sleep rem-sleep restoring sleep function hypothesis of “drainage” sleep function amyloid-b peptide alzheimer’s disease |
| url | https://www.actabiomedica.ru/jour/article/view/411 |
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