New Applications of Photodynamic Therapy in the Management of Candidiasis
The most important aetiological agent of opportunistic mycoses worldwide is <i>Candida</i> spp. These yeasts can cause severe infections in the host, which may be fatal. Isolates of <i>Candida albicans</i> occur with greater frequency and variable resistance patterns. Photody...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/12/1025 |
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| author | Carmen Rodríguez-Cerdeira Erick Martínez-Herrera Gabriella Fabbrocini Beatriz Sanchez-Blanco Adriana López-Barcenas May EL-Samahy Eder R. Juárez-Durán José Luís González-Cespón |
| author_facet | Carmen Rodríguez-Cerdeira Erick Martínez-Herrera Gabriella Fabbrocini Beatriz Sanchez-Blanco Adriana López-Barcenas May EL-Samahy Eder R. Juárez-Durán José Luís González-Cespón |
| author_sort | Carmen Rodríguez-Cerdeira |
| collection | DOAJ |
| description | The most important aetiological agent of opportunistic mycoses worldwide is <i>Candida</i> spp. These yeasts can cause severe infections in the host, which may be fatal. Isolates of <i>Candida albicans</i> occur with greater frequency and variable resistance patterns. Photodynamic therapy (PDT) has been recognised as an alternative treatment to kill pathogenic microorganisms. PDT utilises a photosensitizer, which is activated at a specific wavelength and oxygen concentration. Their reaction yields reactive oxygen species that kill the infectious microorganism. A systematic review of new applications of PDT in the management of candidiasis was performed. Of the 222 studies selected for in-depth screening, 84 were included in this study. All the studies reported the antifungal effectiveness, toxicity and dosimetry of treatment with antimicrobial PDT (aPDT) with different photosensitizers against <i>Candida</i> spp. The manuscripts that are discussed reveal the breadth of the new applications of aPDT against <i>Candida</i> spp., which are resistant to common antifungals. aPDT has superior performance compared to conventional antifungal therapies. With further studies, aPDT should prove valuable in daily clinical practice. |
| first_indexed | 2024-03-10T03:48:18Z |
| format | Article |
| id | doaj.art-e4b186a1035a45088e01bcf98f9c083c |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T03:48:18Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-e4b186a1035a45088e01bcf98f9c083c2023-11-23T09:04:46ZengMDPI AGJournal of Fungi2309-608X2021-11-01712102510.3390/jof7121025New Applications of Photodynamic Therapy in the Management of CandidiasisCarmen Rodríguez-Cerdeira0Erick Martínez-Herrera1Gabriella Fabbrocini2Beatriz Sanchez-Blanco3Adriana López-Barcenas4May EL-Samahy5Eder R. Juárez-Durán6José Luís González-Cespón7Efficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, 36213 Vigo, SpainEfficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, 36213 Vigo, SpainEuropean Women’s Dermatologic and Venereologic Society (EWDVS), 36700 Tui, SpainEfficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, 36213 Vigo, SpainEuropean Women’s Dermatologic and Venereologic Society (EWDVS), 36700 Tui, SpainEuropean Women’s Dermatologic and Venereologic Society (EWDVS), 36700 Tui, SpainEfficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, 36213 Vigo, SpainEfficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, 36213 Vigo, SpainThe most important aetiological agent of opportunistic mycoses worldwide is <i>Candida</i> spp. These yeasts can cause severe infections in the host, which may be fatal. Isolates of <i>Candida albicans</i> occur with greater frequency and variable resistance patterns. Photodynamic therapy (PDT) has been recognised as an alternative treatment to kill pathogenic microorganisms. PDT utilises a photosensitizer, which is activated at a specific wavelength and oxygen concentration. Their reaction yields reactive oxygen species that kill the infectious microorganism. A systematic review of new applications of PDT in the management of candidiasis was performed. Of the 222 studies selected for in-depth screening, 84 were included in this study. All the studies reported the antifungal effectiveness, toxicity and dosimetry of treatment with antimicrobial PDT (aPDT) with different photosensitizers against <i>Candida</i> spp. The manuscripts that are discussed reveal the breadth of the new applications of aPDT against <i>Candida</i> spp., which are resistant to common antifungals. aPDT has superior performance compared to conventional antifungal therapies. With further studies, aPDT should prove valuable in daily clinical practice.https://www.mdpi.com/2309-608X/7/12/1025photosensitizernanocarriers<i>Candida</i> spp.genesantimicrobial photodynamic therapy |
| spellingShingle | Carmen Rodríguez-Cerdeira Erick Martínez-Herrera Gabriella Fabbrocini Beatriz Sanchez-Blanco Adriana López-Barcenas May EL-Samahy Eder R. Juárez-Durán José Luís González-Cespón New Applications of Photodynamic Therapy in the Management of Candidiasis Journal of Fungi photosensitizer nanocarriers <i>Candida</i> spp. genes antimicrobial photodynamic therapy |
| title | New Applications of Photodynamic Therapy in the Management of Candidiasis |
| title_full | New Applications of Photodynamic Therapy in the Management of Candidiasis |
| title_fullStr | New Applications of Photodynamic Therapy in the Management of Candidiasis |
| title_full_unstemmed | New Applications of Photodynamic Therapy in the Management of Candidiasis |
| title_short | New Applications of Photodynamic Therapy in the Management of Candidiasis |
| title_sort | new applications of photodynamic therapy in the management of candidiasis |
| topic | photosensitizer nanocarriers <i>Candida</i> spp. genes antimicrobial photodynamic therapy |
| url | https://www.mdpi.com/2309-608X/7/12/1025 |
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