The role of extracellular matrix in angiogenesis: Beyond adhesion and structure
While the extracellular matrix (ECM) has long been recognized for its structural contributions, anchoring cells for adhesion, providing mechanical support, and maintaining tissue integrity, recent efforts have elucidated its dynamic, reciprocal, and diverse properties on angiogenesis. The ECM modula...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | English |
| Publicado: |
Elsevier
2024-09-01
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| Colección: | Biomaterials and Biosystems |
| Materias: | |
| Acceso en línea: | http://www.sciencedirect.com/science/article/pii/S2666534424000102 |
| _version_ | 1827110854933348352 |
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| author | Jaxson R. Libby Haley Royce Sarah R. Walker Linqing Li |
| author_facet | Jaxson R. Libby Haley Royce Sarah R. Walker Linqing Li |
| author_sort | Jaxson R. Libby |
| collection | DOAJ |
| description | While the extracellular matrix (ECM) has long been recognized for its structural contributions, anchoring cells for adhesion, providing mechanical support, and maintaining tissue integrity, recent efforts have elucidated its dynamic, reciprocal, and diverse properties on angiogenesis. The ECM modulates angiogenic signaling and mechanical transduction, influences the extent and degree of receptor activation, controls cellular behaviors, and serves as a reservoir for bioactive macromolecules. Collectively, these factors guide the formation, maturation, and stabilization of a functional vascular network. This review aims to shed light on the versatile roles of the ECM in angiogenesis, transcending its traditional functions as a mere structural material. We will explore its engagement and synergy in signaling modulation, interactions with various angiogenic factors, and highlight its importance in both health and disease. By capturing the essence of the ECM's diverse functionalities, we highlight the significance in the broader context of vascular biology, enabling the design of novel biomaterials to engineer vascularized tissues and their potential therapeutic implications. |
| first_indexed | 2025-03-20T11:04:55Z |
| format | Article |
| id | doaj.art-e4b244f15fd64deabdceb8f8e38d608b |
| institution | Directory Open Access Journal |
| issn | 2666-5344 |
| language | English |
| last_indexed | 2025-03-20T11:04:55Z |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomaterials and Biosystems |
| spelling | doaj.art-e4b244f15fd64deabdceb8f8e38d608b2024-09-19T10:30:25ZengElsevierBiomaterials and Biosystems2666-53442024-09-0115100097The role of extracellular matrix in angiogenesis: Beyond adhesion and structureJaxson R. Libby0Haley Royce1Sarah R. Walker2Linqing Li3Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH, USADepartment of Chemical Engineering and Bioengineering, University of New Hampshire, Durham, NH, USADepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH, USADepartment of Chemical Engineering and Bioengineering, University of New Hampshire, Durham, NH, USA; Corresponding author.While the extracellular matrix (ECM) has long been recognized for its structural contributions, anchoring cells for adhesion, providing mechanical support, and maintaining tissue integrity, recent efforts have elucidated its dynamic, reciprocal, and diverse properties on angiogenesis. The ECM modulates angiogenic signaling and mechanical transduction, influences the extent and degree of receptor activation, controls cellular behaviors, and serves as a reservoir for bioactive macromolecules. Collectively, these factors guide the formation, maturation, and stabilization of a functional vascular network. This review aims to shed light on the versatile roles of the ECM in angiogenesis, transcending its traditional functions as a mere structural material. We will explore its engagement and synergy in signaling modulation, interactions with various angiogenic factors, and highlight its importance in both health and disease. By capturing the essence of the ECM's diverse functionalities, we highlight the significance in the broader context of vascular biology, enabling the design of novel biomaterials to engineer vascularized tissues and their potential therapeutic implications.http://www.sciencedirect.com/science/article/pii/S2666534424000102AngiogenesisExtracellular matrixGrowth factorsCell adhesionBiomaterialsWound healing |
| spellingShingle | Jaxson R. Libby Haley Royce Sarah R. Walker Linqing Li The role of extracellular matrix in angiogenesis: Beyond adhesion and structure Biomaterials and Biosystems Angiogenesis Extracellular matrix Growth factors Cell adhesion Biomaterials Wound healing |
| title | The role of extracellular matrix in angiogenesis: Beyond adhesion and structure |
| title_full | The role of extracellular matrix in angiogenesis: Beyond adhesion and structure |
| title_fullStr | The role of extracellular matrix in angiogenesis: Beyond adhesion and structure |
| title_full_unstemmed | The role of extracellular matrix in angiogenesis: Beyond adhesion and structure |
| title_short | The role of extracellular matrix in angiogenesis: Beyond adhesion and structure |
| title_sort | role of extracellular matrix in angiogenesis beyond adhesion and structure |
| topic | Angiogenesis Extracellular matrix Growth factors Cell adhesion Biomaterials Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S2666534424000102 |
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