Determination of methylated CpG sites in the promoter region of catechol-O-methyltransferase (<i>COMT</i>) and their involvement in the etiology of tobacco smoking

Determination of methylated CpG sites in the promoter region of catechol-O-methyltransferase (<i>COMT</i>) and their involvement in the etiology of tobacco smoking

We previously reported that catechol-O-methyltransferase (COMT) is significantly associated with nicotine dependence (ND) in humans. In this study, we examined whether there exists any difference in the extent of methylation of CpG dinucleotides in the promoter region of COMT in smokers and nonsmoke...

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Bibliographic Details
Main Authors: Qing Xu, Jennie Z Ma, Thomas J Payne, Ming D Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-06-01
Series:Frontiers in Psychiatry
Subjects:
Methylation
Nicotine
Promoter
CpG site
MB-COMT
tobacco smoking
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2010.00016/full

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