Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizures
This work aimed to develop and produce lacosamide-loaded niosomes coated with chitosan (LCA-CTS-NSM) using a thin-film hydration method and the Box-Behnken design. The effect of three independent factors (Span 60 amount, chitosan concentration, and cholesterol amount) on vesicle size, entrapment eff...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | International Journal of Pharmaceutics: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590156723000506 |
| _version_ | 1797741443458007040 |
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| author | Alaa S. Tulbah Mohammed H. Elkomy Randa Mohammed Zaki Hussein M. Eid Essam M. Eissa Adel A. Ali Heba A. Yassin Basmah Nasser Aldosari Ibrahim A. Naguib Amira H. Hassan |
| author_facet | Alaa S. Tulbah Mohammed H. Elkomy Randa Mohammed Zaki Hussein M. Eid Essam M. Eissa Adel A. Ali Heba A. Yassin Basmah Nasser Aldosari Ibrahim A. Naguib Amira H. Hassan |
| author_sort | Alaa S. Tulbah |
| collection | DOAJ |
| description | This work aimed to develop and produce lacosamide-loaded niosomes coated with chitosan (LCA-CTS-NSM) using a thin-film hydration method and the Box-Behnken design. The effect of three independent factors (Span 60 amount, chitosan concentration, and cholesterol amount) on vesicle size, entrapment efficiency, zeta potential, and cumulative release (8 h) was studied. The optimal formulation of LCA-CTS-NSM was chosen from the design space and assessed for morphology, in vitro release, nasal diffusion, stability, tolerability, and in vivo biodistribution for brain targeting after intranasal delivery. The vesicle size, entrapment, surface charge, and in vitro release of the optimal formula were found to be 194.3 nm, 58.3%, +35.6 mV, and 81.3%, respectively. Besides, it exhibits sustained release behavior, enhanced nasal diffusion, and improved physical stability. Histopathological testing revealed no evidence of toxicity or structural damage to the nasal mucosa. It demonstrated significantly more brain distribution than the drug solution. Overall, the data is encouraging since it points to the potential for non-invasive intranasal administration of LCA as an alternative to oral or parenteral routes. |
| first_indexed | 2024-03-12T14:26:47Z |
| format | Article |
| id | doaj.art-e4b4a6b37e664cf598d4737476fde337 |
| institution | Directory Open Access Journal |
| issn | 2590-1567 |
| language | English |
| last_indexed | 2024-03-12T14:26:47Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Pharmaceutics: X |
| spelling | doaj.art-e4b4a6b37e664cf598d4737476fde3372023-08-18T04:31:31ZengElsevierInternational Journal of Pharmaceutics: X2590-15672023-12-016100206Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizuresAlaa S. Tulbah0Mohammed H. Elkomy1Randa Mohammed Zaki2Hussein M. Eid3Essam M. Eissa4Adel A. Ali5Heba A. Yassin6Basmah Nasser Aldosari7Ibrahim A. Naguib8Amira H. Hassan9Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia; Corresponding authors.Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62511, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62511, Egypt; Corresponding authors.Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62511, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62511, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Sinai University (Arish campus), Arish, EgyptDepartment of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62511, EgyptThis work aimed to develop and produce lacosamide-loaded niosomes coated with chitosan (LCA-CTS-NSM) using a thin-film hydration method and the Box-Behnken design. The effect of three independent factors (Span 60 amount, chitosan concentration, and cholesterol amount) on vesicle size, entrapment efficiency, zeta potential, and cumulative release (8 h) was studied. The optimal formulation of LCA-CTS-NSM was chosen from the design space and assessed for morphology, in vitro release, nasal diffusion, stability, tolerability, and in vivo biodistribution for brain targeting after intranasal delivery. The vesicle size, entrapment, surface charge, and in vitro release of the optimal formula were found to be 194.3 nm, 58.3%, +35.6 mV, and 81.3%, respectively. Besides, it exhibits sustained release behavior, enhanced nasal diffusion, and improved physical stability. Histopathological testing revealed no evidence of toxicity or structural damage to the nasal mucosa. It demonstrated significantly more brain distribution than the drug solution. Overall, the data is encouraging since it points to the potential for non-invasive intranasal administration of LCA as an alternative to oral or parenteral routes.http://www.sciencedirect.com/science/article/pii/S2590156723000506IntranasalPharmacokineticsNose-to-brain deliveryFocal seizuresAntiepilepticChitosomes |
| spellingShingle | Alaa S. Tulbah Mohammed H. Elkomy Randa Mohammed Zaki Hussein M. Eid Essam M. Eissa Adel A. Ali Heba A. Yassin Basmah Nasser Aldosari Ibrahim A. Naguib Amira H. Hassan Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizures International Journal of Pharmaceutics: X Intranasal Pharmacokinetics Nose-to-brain delivery Focal seizures Antiepileptic Chitosomes |
| title | Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizures |
| title_full | Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizures |
| title_fullStr | Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizures |
| title_full_unstemmed | Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizures |
| title_short | Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizures |
| title_sort | novel nasal niosomes loaded with lacosamide and coated with chitosan a possible pathway to target the brain to control partial onset seizures |
| topic | Intranasal Pharmacokinetics Nose-to-brain delivery Focal seizures Antiepileptic Chitosomes |
| url | http://www.sciencedirect.com/science/article/pii/S2590156723000506 |
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