Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke
Abstract We aimed to assess the prognostic value of serum β-synuclein (β-syn), neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in patients with moderate-to-severe acute ischemic stroke. We measured β-syn, GFAP and NfL in serum samples collected one day after admission in 3...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-47765-7 |
| _version_ | 1827603718109921280 |
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| author | Lorenzo Barba Christoph Vollmuth Samir Abu-Rumeileh Steffen Halbgebauer Patrick Oeckl Petra Steinacker Alexander M. Kollikowski Cara Schultz Judith Wolf Mirko Pham Michael K. Schuhmann Peter U. Heuschmann Karl Georg Haeusler Guido Stoll Hermann Neugebauer Markus Otto |
| author_facet | Lorenzo Barba Christoph Vollmuth Samir Abu-Rumeileh Steffen Halbgebauer Patrick Oeckl Petra Steinacker Alexander M. Kollikowski Cara Schultz Judith Wolf Mirko Pham Michael K. Schuhmann Peter U. Heuschmann Karl Georg Haeusler Guido Stoll Hermann Neugebauer Markus Otto |
| author_sort | Lorenzo Barba |
| collection | DOAJ |
| description | Abstract We aimed to assess the prognostic value of serum β-synuclein (β-syn), neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in patients with moderate-to-severe acute ischemic stroke. We measured β-syn, GFAP and NfL in serum samples collected one day after admission in 30 adult patients with moderate-to-severe ischemic stroke due to middle cerebral artery (MCA) occlusion. We tested the associations between biomarker levels and clinical and radiological scores (National Institute of Health Stroke Scale scores, NIHSS, and Alberta Stroke Program Early CT Score, ASPECTS), as well as measures of functional outcome (modified Rankin Scale, mRS). Serum biomarkers were significantly associated with ASPECTS values (β-syn p = 0.0011, GFAP p = 0.0002) but not with NIHSS scores at admission. Patients who received mechanical thrombectomy and intravenous thrombolysis showed lower β-syn (p = 0.029) und NfL concentrations (p = 0.0024) compared to patients who received only mechanical thrombectomy. According to median biomarker levels, patients with high β-syn, NfL or GFAP levels showed, after therapy, lower clinical improvement (i.e., lower 24-h NIHSS change), higher NIHSS scores during hospitalization and higher mRS scores at 3-month follow-up. Elevated serum concentrations of β-syn (p = 0.016), NfL (p = 0.020) or GFAP (p = 0.010) were significantly associated with 3-month mRS of 3–6 vs. 0–2 even after accounting for age, sex and renal function. In patients with moderate-to-severe acute ischemic stroke, serum β-syn, NfL and GFAP levels associated with clinical and radiological scores at different timepoints and were able to predict short- and middle-term clinical outcomes. |
| first_indexed | 2024-03-09T05:44:39Z |
| format | Article |
| id | doaj.art-e4b568f07c824155bc3dfb236de0636a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T05:44:39Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e4b568f07c824155bc3dfb236de0636a2023-12-03T12:22:22ZengNature PortfolioScientific Reports2045-23222023-11-011311710.1038/s41598-023-47765-7Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic strokeLorenzo Barba0Christoph Vollmuth1Samir Abu-Rumeileh2Steffen Halbgebauer3Patrick Oeckl4Petra Steinacker5Alexander M. Kollikowski6Cara Schultz7Judith Wolf8Mirko Pham9Michael K. Schuhmann10Peter U. Heuschmann11Karl Georg Haeusler12Guido Stoll13Hermann Neugebauer14Markus Otto15Department of Neurology, Martin-Luther-University of Halle-WittenbergDepartment of Neurology, University of WürzburgDepartment of Neurology, Martin-Luther-University of Halle-WittenbergDepartment of Neurology, University of UlmDepartment of Neurology, University of UlmDepartment of Neurology, Martin-Luther-University of Halle-WittenbergDepartment of Neuroradiology, University of WürzburgDepartment of Neurology, University of WürzburgDepartment of Neurology, University of WürzburgDepartment of Neuroradiology, University of WürzburgDepartment of Neurology, University of WürzburgInstitute for Clinical Epidemiology and Biometry, University of WürzburgDepartment of Neurology, University of WürzburgDepartment of Neurology, University of WürzburgDepartment of Neurology, University of WürzburgDepartment of Neurology, Martin-Luther-University of Halle-WittenbergAbstract We aimed to assess the prognostic value of serum β-synuclein (β-syn), neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in patients with moderate-to-severe acute ischemic stroke. We measured β-syn, GFAP and NfL in serum samples collected one day after admission in 30 adult patients with moderate-to-severe ischemic stroke due to middle cerebral artery (MCA) occlusion. We tested the associations between biomarker levels and clinical and radiological scores (National Institute of Health Stroke Scale scores, NIHSS, and Alberta Stroke Program Early CT Score, ASPECTS), as well as measures of functional outcome (modified Rankin Scale, mRS). Serum biomarkers were significantly associated with ASPECTS values (β-syn p = 0.0011, GFAP p = 0.0002) but not with NIHSS scores at admission. Patients who received mechanical thrombectomy and intravenous thrombolysis showed lower β-syn (p = 0.029) und NfL concentrations (p = 0.0024) compared to patients who received only mechanical thrombectomy. According to median biomarker levels, patients with high β-syn, NfL or GFAP levels showed, after therapy, lower clinical improvement (i.e., lower 24-h NIHSS change), higher NIHSS scores during hospitalization and higher mRS scores at 3-month follow-up. Elevated serum concentrations of β-syn (p = 0.016), NfL (p = 0.020) or GFAP (p = 0.010) were significantly associated with 3-month mRS of 3–6 vs. 0–2 even after accounting for age, sex and renal function. In patients with moderate-to-severe acute ischemic stroke, serum β-syn, NfL and GFAP levels associated with clinical and radiological scores at different timepoints and were able to predict short- and middle-term clinical outcomes.https://doi.org/10.1038/s41598-023-47765-7 |
| spellingShingle | Lorenzo Barba Christoph Vollmuth Samir Abu-Rumeileh Steffen Halbgebauer Patrick Oeckl Petra Steinacker Alexander M. Kollikowski Cara Schultz Judith Wolf Mirko Pham Michael K. Schuhmann Peter U. Heuschmann Karl Georg Haeusler Guido Stoll Hermann Neugebauer Markus Otto Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke Scientific Reports |
| title | Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke |
| title_full | Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke |
| title_fullStr | Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke |
| title_full_unstemmed | Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke |
| title_short | Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke |
| title_sort | serum β synuclein neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate to severe acute ischemic stroke |
| url | https://doi.org/10.1038/s41598-023-47765-7 |
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