Intensified anti-TNF treatment downregulates the phenotype in ulcerative colitis: a 13-year prospective follow-up study

Intensified anti-TNF treatment downregulates the phenotype in ulcerative colitis: a 13-year prospective follow-up study

BackgroundModerate to severe ulcerative colitis (UC) is generally treated with a step-up algorithm from 5-aminosalicylic acid (5-ASA) to biological agents. There is no general recommendation if or when to de-escalate or discontinue biological therapy. In this study, we performed biological therapy w...

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Bibliographic Details
Main Authors: Jon Florholmen, Rasmus Goll, Kay-Martin Johnsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Gastroenterology
Subjects:
ulcerative colitis
anti-TNF
discontinuation
remission
mucosal TNF
Online Access:https://www.frontiersin.org/articles/10.3389/fgstr.2023.1304944/full

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