The Mutation in <i>wbaP cps</i> Gene Cluster Selected by Phage-Borne Depolymerase Abolishes Capsule Production and Diminishes the Virulence of <i>Klebsiella pneumoniae</i>

The Mutation in <i>wbaP cps</i> Gene Cluster Selected by Phage-Borne Depolymerase Abolishes Capsule Production and Diminishes the Virulence of <i>Klebsiella pneumoniae</i>

<i>Klebsiella pneumoniae</i> is considered one of the most critical multidrug-resistant pathogens and urgently requires new therapeutic strategies. Capsular polysaccharides (CPS), lipopolysaccharides (LPS), and exopolysaccharides (EPS) are the major virulence factors protecting <i>...

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Bibliographic Details
Main Authors: Marta Kaszowska, Grazyna Majkowska-Skrobek, Pawel Markwitz, Cédric Lood, Wojciech Jachymek, Anna Maciejewska, Jolanta Lukasiewicz, Zuzanna Drulis-Kawa
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Klebsiella</i> phage
capsule degrading depolymerase
phage resistant mutant
capsular polysaccharide
Online Access:https://www.mdpi.com/1422-0067/22/21/11562

Internet

https://www.mdpi.com/1422-0067/22/21/11562

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