Possible genetic implications in the response to cardiac resynchronisation therapy in a patient affected by heart failure
This report presents a case of a patient with idiopathic dilated cardiomyopathy and severe left ventricular systolic dysfunction who underwent cardiac resynchronisation therapy (CRT). During the follow-up a progressive increase in left ventricular ejection fraction was observed, as well as clinical...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SEEd
2011-06-01
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| Series: | Clinical Management Issues |
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| Online Access: | https://journals.seedmedicalpublishers.com/index.php/cmi/article/view/507 |
| _version_ | 1818536473134104576 |
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| author | Natalia Pezzali Marco Metra Livio Dei Cas |
| author_facet | Natalia Pezzali Marco Metra Livio Dei Cas |
| author_sort | Natalia Pezzali |
| collection | DOAJ |
| description | This report presents a case of a patient with idiopathic dilated cardiomyopathy and severe left ventricular systolic dysfunction who underwent cardiac resynchronisation therapy (CRT). During the follow-up a progressive increase in left ventricular ejection fraction was observed, as well as clinical improvement. No cardiovascular events occurred during the follow-up, except for appropriate Implantable Cardioverter Defibrillator (ICD) bursts for fast ventricular tachycardia. Genotyping for adrenoceptor gene polymorphisms detected that the patient was Glu27Glu homozygous carrier. There’s a large interindividual variability in response to CRT. Despite attempts to identify factors having an impact on this therapy, only QRS duration is accepted according to guidelines. Beta-adrenoceptors polymorphisms, modulating sympathetic drive in heart failure and left ventricular remodelling, may have a role in identifying patients with a better response to CRT, in order to target and individualise the patients’ treatment. |
| first_indexed | 2024-12-11T18:38:24Z |
| format | Article |
| id | doaj.art-e4b97565d7204fd388e60462133a9d7b |
| institution | Directory Open Access Journal |
| issn | 1973-4832 2283-3137 |
| language | English |
| last_indexed | 2024-12-11T18:38:24Z |
| publishDate | 2011-06-01 |
| publisher | SEEd |
| record_format | Article |
| series | Clinical Management Issues |
| spelling | doaj.art-e4b97565d7204fd388e60462133a9d7b2022-12-22T00:54:42ZengSEEdClinical Management Issues1973-48322283-31372011-06-0152616810.7175/cmi.v5i2.507474Possible genetic implications in the response to cardiac resynchronisation therapy in a patient affected by heart failureNatalia Pezzali0Marco Metra1Livio Dei Cas2Cardiologia, Dipartimento di Medicina Sperimentale e Applicata, Università e Spedali Civili di BresciaCardiologia, Dipartimento di Medicina Sperimentale e Applicata, Università e Spedali Civili di BresciaCardiologia, Dipartimento di Medicina Sperimentale e Applicata, Università e Spedali Civili di BresciaThis report presents a case of a patient with idiopathic dilated cardiomyopathy and severe left ventricular systolic dysfunction who underwent cardiac resynchronisation therapy (CRT). During the follow-up a progressive increase in left ventricular ejection fraction was observed, as well as clinical improvement. No cardiovascular events occurred during the follow-up, except for appropriate Implantable Cardioverter Defibrillator (ICD) bursts for fast ventricular tachycardia. Genotyping for adrenoceptor gene polymorphisms detected that the patient was Glu27Glu homozygous carrier. There’s a large interindividual variability in response to CRT. Despite attempts to identify factors having an impact on this therapy, only QRS duration is accepted according to guidelines. Beta-adrenoceptors polymorphisms, modulating sympathetic drive in heart failure and left ventricular remodelling, may have a role in identifying patients with a better response to CRT, in order to target and individualise the patients’ treatment.https://journals.seedmedicalpublishers.com/index.php/cmi/article/view/507Heart failureCardiac resynchronisation therapyGenetic polymorphisms |
| spellingShingle | Natalia Pezzali Marco Metra Livio Dei Cas Possible genetic implications in the response to cardiac resynchronisation therapy in a patient affected by heart failure Clinical Management Issues Heart failure Cardiac resynchronisation therapy Genetic polymorphisms |
| title | Possible genetic implications in the response to cardiac resynchronisation therapy in a patient affected by heart failure |
| title_full | Possible genetic implications in the response to cardiac resynchronisation therapy in a patient affected by heart failure |
| title_fullStr | Possible genetic implications in the response to cardiac resynchronisation therapy in a patient affected by heart failure |
| title_full_unstemmed | Possible genetic implications in the response to cardiac resynchronisation therapy in a patient affected by heart failure |
| title_short | Possible genetic implications in the response to cardiac resynchronisation therapy in a patient affected by heart failure |
| title_sort | possible genetic implications in the response to cardiac resynchronisation therapy in a patient affected by heart failure |
| topic | Heart failure Cardiac resynchronisation therapy Genetic polymorphisms |
| url | https://journals.seedmedicalpublishers.com/index.php/cmi/article/view/507 |
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