Retrospective Cohort Study of Lassa Fever in Pregnancy, Southern Nigeria
Lassa fever in pregnancy causes high rates of maternal and fetal death, but limited data are available to guide clinicians. We retrospectively studied 30 pregnant Lassa fever patients treated with early ribavirin therapy and a conservative obstetric approach at a teaching hospital in southern Nigeri...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2019-08-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/25/8/18-1299_article |
| _version_ | 1818021783462215680 |
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| author | Sylvanus Okogbenin Joseph Okoeguale George Akpede Andres Colubri Kayla G. Barnes Samar Mehta Reuben Eifediyi Felix Okogbo Joseph Eigbefoh Mojeed Momoh Mojeed Rafiu Donatus Adomeh Ikponmwosa Odia Chris Aire Rebecca Atafo Martha Okonofua Meike Pahlman Beate Becker-Ziaja Danny Asogun Peter Okokhere Christian Happi Stephan Günther Pardis C. Sabeti Ephraim Ogbaini-Emovon |
| author_facet | Sylvanus Okogbenin Joseph Okoeguale George Akpede Andres Colubri Kayla G. Barnes Samar Mehta Reuben Eifediyi Felix Okogbo Joseph Eigbefoh Mojeed Momoh Mojeed Rafiu Donatus Adomeh Ikponmwosa Odia Chris Aire Rebecca Atafo Martha Okonofua Meike Pahlman Beate Becker-Ziaja Danny Asogun Peter Okokhere Christian Happi Stephan Günther Pardis C. Sabeti Ephraim Ogbaini-Emovon |
| author_sort | Sylvanus Okogbenin |
| collection | DOAJ |
| description | Lassa fever in pregnancy causes high rates of maternal and fetal death, but limited data are available to guide clinicians. We retrospectively studied 30 pregnant Lassa fever patients treated with early ribavirin therapy and a conservative obstetric approach at a teaching hospital in southern Nigeria during January 2009–March 2018. Eleven (36.7%) of 30 women died, and 20/31 (64.5%) pregnancies ended in fetal or perinatal loss. On initial evaluation, 17/30 (56.6%) women had a dead fetus; 10/17 (58.8%) of these patients died, compared with 1/13 (7.7%) of women with a live fetus. Extravaginal bleeding, convulsions, and oliguria each were independently associated with maternal and fetal or perinatal death, whereas seeking care in the third trimester was not. For women with a live fetus at initial evaluation, the positive outcomes observed contrast with previous reports, and they support a conservative approach to obstetric management of Lassa fever in pregnancy in Nigeria. |
| first_indexed | 2024-04-14T08:22:36Z |
| format | Article |
| id | doaj.art-e4ba3e66850f4f659119007cbca67685 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-14T08:22:36Z |
| publishDate | 2019-08-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-e4ba3e66850f4f659119007cbca676852022-12-22T02:04:10ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592019-08-012581494150010.3201/eid2508.181299Retrospective Cohort Study of Lassa Fever in Pregnancy, Southern NigeriaSylvanus OkogbeninJoseph OkoegualeGeorge AkpedeAndres ColubriKayla G. BarnesSamar MehtaReuben EifediyiFelix OkogboJoseph EigbefohMojeed MomohMojeed RafiuDonatus AdomehIkponmwosa OdiaChris AireRebecca AtafoMartha OkonofuaMeike PahlmanBeate Becker-ZiajaDanny AsogunPeter OkokhereChristian HappiStephan GüntherPardis C. SabetiEphraim Ogbaini-EmovonLassa fever in pregnancy causes high rates of maternal and fetal death, but limited data are available to guide clinicians. We retrospectively studied 30 pregnant Lassa fever patients treated with early ribavirin therapy and a conservative obstetric approach at a teaching hospital in southern Nigeria during January 2009–March 2018. Eleven (36.7%) of 30 women died, and 20/31 (64.5%) pregnancies ended in fetal or perinatal loss. On initial evaluation, 17/30 (56.6%) women had a dead fetus; 10/17 (58.8%) of these patients died, compared with 1/13 (7.7%) of women with a live fetus. Extravaginal bleeding, convulsions, and oliguria each were independently associated with maternal and fetal or perinatal death, whereas seeking care in the third trimester was not. For women with a live fetus at initial evaluation, the positive outcomes observed contrast with previous reports, and they support a conservative approach to obstetric management of Lassa fever in pregnancy in Nigeria.https://wwwnc.cdc.gov/eid/article/25/8/18-1299_articleLassa feverpregnancysouthern NigeriaWest Africavirusesvector-borne infections |
| spellingShingle | Sylvanus Okogbenin Joseph Okoeguale George Akpede Andres Colubri Kayla G. Barnes Samar Mehta Reuben Eifediyi Felix Okogbo Joseph Eigbefoh Mojeed Momoh Mojeed Rafiu Donatus Adomeh Ikponmwosa Odia Chris Aire Rebecca Atafo Martha Okonofua Meike Pahlman Beate Becker-Ziaja Danny Asogun Peter Okokhere Christian Happi Stephan Günther Pardis C. Sabeti Ephraim Ogbaini-Emovon Retrospective Cohort Study of Lassa Fever in Pregnancy, Southern Nigeria Emerging Infectious Diseases Lassa fever pregnancy southern Nigeria West Africa viruses vector-borne infections |
| title | Retrospective Cohort Study of Lassa Fever in Pregnancy, Southern Nigeria |
| title_full | Retrospective Cohort Study of Lassa Fever in Pregnancy, Southern Nigeria |
| title_fullStr | Retrospective Cohort Study of Lassa Fever in Pregnancy, Southern Nigeria |
| title_full_unstemmed | Retrospective Cohort Study of Lassa Fever in Pregnancy, Southern Nigeria |
| title_short | Retrospective Cohort Study of Lassa Fever in Pregnancy, Southern Nigeria |
| title_sort | retrospective cohort study of lassa fever in pregnancy southern nigeria |
| topic | Lassa fever pregnancy southern Nigeria West Africa viruses vector-borne infections |
| url | https://wwwnc.cdc.gov/eid/article/25/8/18-1299_article |
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