Therapeutic effects of electrospun chitosan nanofibers on animal skin wounds: A systematic review and meta-analysis
Electrospun chitosan nanofibers (QSNFs) enhance the healing process by mimicking skin structure and function. The aim of this study was to analyze the therapeutic effects of QSNFs application on animal skin wounds to identify a potential direction for translational research in dermatology. The PRISM...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | International Journal of Pharmaceutics: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590156723000191 |
| _version_ | 1797798703368503296 |
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| author | Dalia Isabel Sánchez-Machado Anahí Maldonado-Cabrera Jaime López-Cervantes Blayra Maldonado-Cabrera Andrés Francisco Chávez-Almanza |
| author_facet | Dalia Isabel Sánchez-Machado Anahí Maldonado-Cabrera Jaime López-Cervantes Blayra Maldonado-Cabrera Andrés Francisco Chávez-Almanza |
| author_sort | Dalia Isabel Sánchez-Machado |
| collection | DOAJ |
| description | Electrospun chitosan nanofibers (QSNFs) enhance the healing process by mimicking skin structure and function. The aim of this study was to analyze the therapeutic effects of QSNFs application on animal skin wounds to identify a potential direction for translational research in dermatology. The PRISMA methodology and the PICO scheme were used. A random effects model and mean difference analysis were applied for the meta-analysis. A meta-regression model was constructed, risk of bias was determined, and methodological quality assessment was performed. Of the 2370 articles collected, 54 studies were selected based on the inclusion and exclusion criteria. The wound healing area was used for building models on the 3rd, 7th, and 14th days of follow-up; the results were − 10.4% (95% CI, −18.2% to −2.6%, p = 0.001), −21.0% (95% CI, −27.3% to −14.7%, p = 0.001), and − 14.0% (95% CI, −19.1 to −8.8%, p = 0.001), respectively. Antioxidants and synthetic polymers combined with QSNFs further reduced skin wound areas (p < 0.05). The results show a more efficient reduction in wound area percentages in experimental groups than in control groups, so QSNFs could potentially be applied in translational human medicine research. |
| first_indexed | 2024-03-13T04:07:50Z |
| format | Article |
| id | doaj.art-e4bb7c4431ac4938bae70ffad610c5e3 |
| institution | Directory Open Access Journal |
| issn | 2590-1567 |
| language | English |
| last_indexed | 2024-03-13T04:07:50Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Pharmaceutics: X |
| spelling | doaj.art-e4bb7c4431ac4938bae70ffad610c5e32023-06-21T06:59:14ZengElsevierInternational Journal of Pharmaceutics: X2590-15672023-12-015100175Therapeutic effects of electrospun chitosan nanofibers on animal skin wounds: A systematic review and meta-analysisDalia Isabel Sánchez-Machado0Anahí Maldonado-Cabrera1Jaime López-Cervantes2Blayra Maldonado-Cabrera3Andrés Francisco Chávez-Almanza4Technologic Institute of Sonora (ITSON), Ciudad Obregon MX-85000, Sonora, MexicoTechnologic Institute of Sonora (ITSON), Ciudad Obregon MX-85000, Sonora, Mexico; Mexican Social Security Institute (IMSS), Hermosillo MX-83000, Sonora, MexicoTechnologic Institute of Sonora (ITSON), Ciudad Obregon MX-85000, Sonora, Mexico; Corresponding author.Technologic Institute of Sonora (ITSON), Ciudad Obregon MX-85000, Sonora, MexicoTechnologic Institute of Sonora (ITSON), Ciudad Obregon MX-85000, Sonora, MexicoElectrospun chitosan nanofibers (QSNFs) enhance the healing process by mimicking skin structure and function. The aim of this study was to analyze the therapeutic effects of QSNFs application on animal skin wounds to identify a potential direction for translational research in dermatology. The PRISMA methodology and the PICO scheme were used. A random effects model and mean difference analysis were applied for the meta-analysis. A meta-regression model was constructed, risk of bias was determined, and methodological quality assessment was performed. Of the 2370 articles collected, 54 studies were selected based on the inclusion and exclusion criteria. The wound healing area was used for building models on the 3rd, 7th, and 14th days of follow-up; the results were − 10.4% (95% CI, −18.2% to −2.6%, p = 0.001), −21.0% (95% CI, −27.3% to −14.7%, p = 0.001), and − 14.0% (95% CI, −19.1 to −8.8%, p = 0.001), respectively. Antioxidants and synthetic polymers combined with QSNFs further reduced skin wound areas (p < 0.05). The results show a more efficient reduction in wound area percentages in experimental groups than in control groups, so QSNFs could potentially be applied in translational human medicine research.http://www.sciencedirect.com/science/article/pii/S2590156723000191AnimalNanofibersChitosanFull-thickness skin woundHealing |
| spellingShingle | Dalia Isabel Sánchez-Machado Anahí Maldonado-Cabrera Jaime López-Cervantes Blayra Maldonado-Cabrera Andrés Francisco Chávez-Almanza Therapeutic effects of electrospun chitosan nanofibers on animal skin wounds: A systematic review and meta-analysis International Journal of Pharmaceutics: X Animal Nanofibers Chitosan Full-thickness skin wound Healing |
| title | Therapeutic effects of electrospun chitosan nanofibers on animal skin wounds: A systematic review and meta-analysis |
| title_full | Therapeutic effects of electrospun chitosan nanofibers on animal skin wounds: A systematic review and meta-analysis |
| title_fullStr | Therapeutic effects of electrospun chitosan nanofibers on animal skin wounds: A systematic review and meta-analysis |
| title_full_unstemmed | Therapeutic effects of electrospun chitosan nanofibers on animal skin wounds: A systematic review and meta-analysis |
| title_short | Therapeutic effects of electrospun chitosan nanofibers on animal skin wounds: A systematic review and meta-analysis |
| title_sort | therapeutic effects of electrospun chitosan nanofibers on animal skin wounds a systematic review and meta analysis |
| topic | Animal Nanofibers Chitosan Full-thickness skin wound Healing |
| url | http://www.sciencedirect.com/science/article/pii/S2590156723000191 |
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