Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature

Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature

Abstract Background Down syndrome (DS) is characterized by a genome-wide profile of differential DNA methylation that is skewed towards hypermethylation in most tissues, including brain, and includes pan-tissue differential methylation. The molecular mechanisms involve the overexpression of genes re...

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Bibliographic Details
Main Authors: Benjamin I. Laufer, J. Antonio Gomez, Julia M. Jianu, Janine M. LaSalle
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Epigenetics & Chromatin
Subjects:
DNMT3L
Down syndrome
Whole genome bisulfite sequencing
Bivalent chromatin
Epigenomics
PiggyBac transgenesis
Online Access:https://doi.org/10.1186/s13072-021-00387-7

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