Cellulose Composites with Graphene for Tissue Engineering Applications

Tissue engineering is an interdisciplinary field that combines principles of engineering and life sciences to obtain biomaterials capable of maintaining, improving, or substituting the function of various tissues or even an entire organ. In virtue of its high availability, biocompatibility and versa...

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Main Authors: Madalina Oprea, Stefan Ioan Voicu
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Materials
Subjects:
Online Access:https://www.mdpi.com/1996-1944/13/23/5347
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author Madalina Oprea
Stefan Ioan Voicu
author_facet Madalina Oprea
Stefan Ioan Voicu
author_sort Madalina Oprea
collection DOAJ
description Tissue engineering is an interdisciplinary field that combines principles of engineering and life sciences to obtain biomaterials capable of maintaining, improving, or substituting the function of various tissues or even an entire organ. In virtue of its high availability, biocompatibility and versatility, cellulose was considered a promising platform for such applications. The combination of cellulose with graphene or graphene derivatives leads to the obtainment of superior composites in terms of cellular attachment, growth and proliferation, integration into host tissue, and stem cell differentiation toward specific lineages. The current review provides an up-to-date summary of the status of the field of cellulose composites with graphene for tissue engineering applications. The preparation methods and the biological performance of cellulose paper, bacterial cellulose, and cellulose derivatives-based composites with graphene, graphene oxide and reduced graphene oxide were mainly discussed. The importance of the cellulose-based matrix and the contribution of graphene and graphene derivatives fillers as well as several key applications of these hybrid materials, particularly for the development of multifunctional scaffolds for cell culture, bone and neural tissue regeneration were also highlighted.
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spelling doaj.art-e4bc319c3ea445ca8d5294e78995aa3d2023-11-20T22:20:19ZengMDPI AGMaterials1996-19442020-11-011323534710.3390/ma13235347Cellulose Composites with Graphene for Tissue Engineering ApplicationsMadalina Oprea0Stefan Ioan Voicu1Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Gheorghe Polizu 1-7, 011061 Bucharest, RomaniaFaculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Gheorghe Polizu 1-7, 011061 Bucharest, RomaniaTissue engineering is an interdisciplinary field that combines principles of engineering and life sciences to obtain biomaterials capable of maintaining, improving, or substituting the function of various tissues or even an entire organ. In virtue of its high availability, biocompatibility and versatility, cellulose was considered a promising platform for such applications. The combination of cellulose with graphene or graphene derivatives leads to the obtainment of superior composites in terms of cellular attachment, growth and proliferation, integration into host tissue, and stem cell differentiation toward specific lineages. The current review provides an up-to-date summary of the status of the field of cellulose composites with graphene for tissue engineering applications. The preparation methods and the biological performance of cellulose paper, bacterial cellulose, and cellulose derivatives-based composites with graphene, graphene oxide and reduced graphene oxide were mainly discussed. The importance of the cellulose-based matrix and the contribution of graphene and graphene derivatives fillers as well as several key applications of these hybrid materials, particularly for the development of multifunctional scaffolds for cell culture, bone and neural tissue regeneration were also highlighted.https://www.mdpi.com/1996-1944/13/23/5347scaffoldsmembraneshydrogelscellulosetissue engineering
spellingShingle Madalina Oprea
Stefan Ioan Voicu
Cellulose Composites with Graphene for Tissue Engineering Applications
Materials
scaffolds
membranes
hydrogels
cellulose
tissue engineering
title Cellulose Composites with Graphene for Tissue Engineering Applications
title_full Cellulose Composites with Graphene for Tissue Engineering Applications
title_fullStr Cellulose Composites with Graphene for Tissue Engineering Applications
title_full_unstemmed Cellulose Composites with Graphene for Tissue Engineering Applications
title_short Cellulose Composites with Graphene for Tissue Engineering Applications
title_sort cellulose composites with graphene for tissue engineering applications
topic scaffolds
membranes
hydrogels
cellulose
tissue engineering
url https://www.mdpi.com/1996-1944/13/23/5347
work_keys_str_mv AT madalinaoprea cellulosecompositeswithgraphenefortissueengineeringapplications
AT stefanioanvoicu cellulosecompositeswithgraphenefortissueengineeringapplications