Balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension
Aim. To evaluate the effectiveness of balloon pulmonary angioplasty (BPA) in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Materials and methods. Forty patients with inoperable CTEPH were enrolled in this study. The indications were determined by multidisciplinary t...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2019-04-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/33584/pdf |
| _version_ | 1818555159589945344 |
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| author | N M Danilov Yu G Matchin A M Chernyavsky A G Edemsky D S Grankin O V Sagaydak I E Chazova S A Boytsov A M Karaskov |
| author_facet | N M Danilov Yu G Matchin A M Chernyavsky A G Edemsky D S Grankin O V Sagaydak I E Chazova S A Boytsov A M Karaskov |
| author_sort | N M Danilov |
| collection | DOAJ |
| description | Aim. To evaluate the effectiveness of balloon pulmonary angioplasty (BPA) in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Materials and methods. Forty patients with inoperable CTEPH were enrolled in this study. The indications were determined by multidisciplinary team. The average age of patients was 53.5 [43; 63] years. In 65% of cases patients had functional class III (according to WHO); the distance in the 6-minute walk test (6MWD) was 327 [280; 400] m; catheterization of the right heart revealed systolic pulmonary artery pressure (SPAP) 82 [64; 100] mm Hg, mean pulmonary artery (mPAP) 48.5 [38; 56] mm Hg, pulmonary vascular resistance (PVR) 784 [525; 1257] dyn·s/cm-5. Each patient underwent 6 BPA. Results and discussion. The effectiveness of BPA was assessed 2 months after the last session. According to the data of right heart catheterization SPAP decreased by 27.3%, mPAP by 26%, PVR by 34.5% from baseline. After all series of BPA echocardiography and magnetic resonance imaging demonstrated reverse remodeling of the right heart. Also significant decrease in the level of BNP by 62%, increasing in 6MWD distance by 39% and improvement of the functional class up to I in 60% cases and up to II in 40% cases were noted. Conclusion. The results of the present study demonstrated a high efficacy of BPA allowing to normalize hemodynamic and clinical parameters, increasing the physical activity. Balloon pulmonary angioplasty is a new highly effective, safe method for treating patients with inoperable CTEPH. |
| first_indexed | 2024-12-12T09:49:33Z |
| format | Article |
| id | doaj.art-e4bd74db66de4fb5b545d1fd25aefa42 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-12T09:49:33Z |
| publishDate | 2019-04-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-e4bd74db66de4fb5b545d1fd25aefa422022-12-22T00:28:18Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422019-04-01914434710.26442/00403660.2019.04.00010030314Balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertensionN M Danilov0Yu G Matchin1A M Chernyavsky2A G Edemsky3D S Grankin4O V Sagaydak5I E Chazova6S A Boytsov7A M Karaskov8National Medical Research Center for Cardiology of the Ministry of Health of Russian FederationNational Medical Research Center for Cardiology of the Ministry of Health of Russian FederationE.N. Meshalkin National Medical Research Center of the Ministry of Health of Russian FederationE.N. Meshalkin National Medical Research Center of the Ministry of Health of Russian FederationE.N. Meshalkin National Medical Research Center of the Ministry of Health of Russian FederationNational Medical Research Center for Cardiology of the Ministry of Health of Russian FederationNational Medical Research Center for Cardiology of the Ministry of Health of Russian FederationNational Medical Research Center for Cardiology of the Ministry of Health of Russian FederationE.N. Meshalkin National Medical Research Center of the Ministry of Health of Russian FederationAim. To evaluate the effectiveness of balloon pulmonary angioplasty (BPA) in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Materials and methods. Forty patients with inoperable CTEPH were enrolled in this study. The indications were determined by multidisciplinary team. The average age of patients was 53.5 [43; 63] years. In 65% of cases patients had functional class III (according to WHO); the distance in the 6-minute walk test (6MWD) was 327 [280; 400] m; catheterization of the right heart revealed systolic pulmonary artery pressure (SPAP) 82 [64; 100] mm Hg, mean pulmonary artery (mPAP) 48.5 [38; 56] mm Hg, pulmonary vascular resistance (PVR) 784 [525; 1257] dyn·s/cm-5. Each patient underwent 6 BPA. Results and discussion. The effectiveness of BPA was assessed 2 months after the last session. According to the data of right heart catheterization SPAP decreased by 27.3%, mPAP by 26%, PVR by 34.5% from baseline. After all series of BPA echocardiography and magnetic resonance imaging demonstrated reverse remodeling of the right heart. Also significant decrease in the level of BNP by 62%, increasing in 6MWD distance by 39% and improvement of the functional class up to I in 60% cases and up to II in 40% cases were noted. Conclusion. The results of the present study demonstrated a high efficacy of BPA allowing to normalize hemodynamic and clinical parameters, increasing the physical activity. Balloon pulmonary angioplasty is a new highly effective, safe method for treating patients with inoperable CTEPH.https://ter-arkhiv.ru/0040-3660/article/viewFile/33584/pdfballoon pulmonary angioplastychronic thromboembolic pulmonary hypertension |
| spellingShingle | N M Danilov Yu G Matchin A M Chernyavsky A G Edemsky D S Grankin O V Sagaydak I E Chazova S A Boytsov A M Karaskov Balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension Терапевтический архив balloon pulmonary angioplasty chronic thromboembolic pulmonary hypertension |
| title | Balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension |
| title_full | Balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension |
| title_fullStr | Balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension |
| title_full_unstemmed | Balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension |
| title_short | Balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension |
| title_sort | balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension |
| topic | balloon pulmonary angioplasty chronic thromboembolic pulmonary hypertension |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/33584/pdf |
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