Cardiac muscle thin filament structures reveal calcium regulatory mechanism
The contraction of cardiac and skeletal muscles is regulated by Ca2+ released from the sarcoplasmic reticulum in muscle cells. Here the authors provide molecular insights into Ca2+ regulation of muscle contraction by determining the cryo-EM structures of the human cardiac muscle thin filament in the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-14008-1 |
| _version_ | 1818750513018044416 |
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| author | Yurika Yamada Keiichi Namba Takashi Fujii |
| author_facet | Yurika Yamada Keiichi Namba Takashi Fujii |
| author_sort | Yurika Yamada |
| collection | DOAJ |
| description | The contraction of cardiac and skeletal muscles is regulated by Ca2+ released from the sarcoplasmic reticulum in muscle cells. Here the authors provide molecular insights into Ca2+ regulation of muscle contraction by determining the cryo-EM structures of the human cardiac muscle thin filament in the absence and presence of Ca2+. |
| first_indexed | 2024-12-18T04:20:52Z |
| format | Article |
| id | doaj.art-e4bf2fe3a75243b9ab70287b5d826eb2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:20:52Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e4bf2fe3a75243b9ab70287b5d826eb22022-12-21T21:21:15ZengNature PortfolioNature Communications2041-17232020-01-011111910.1038/s41467-019-14008-1Cardiac muscle thin filament structures reveal calcium regulatory mechanismYurika Yamada0Keiichi Namba1Takashi Fujii2Graduate School of Frontier Biosciences, Osaka UniversityGraduate School of Frontier Biosciences, Osaka UniversityGraduate School of Frontier Biosciences, Osaka UniversityThe contraction of cardiac and skeletal muscles is regulated by Ca2+ released from the sarcoplasmic reticulum in muscle cells. Here the authors provide molecular insights into Ca2+ regulation of muscle contraction by determining the cryo-EM structures of the human cardiac muscle thin filament in the absence and presence of Ca2+.https://doi.org/10.1038/s41467-019-14008-1 |
| spellingShingle | Yurika Yamada Keiichi Namba Takashi Fujii Cardiac muscle thin filament structures reveal calcium regulatory mechanism Nature Communications |
| title | Cardiac muscle thin filament structures reveal calcium regulatory mechanism |
| title_full | Cardiac muscle thin filament structures reveal calcium regulatory mechanism |
| title_fullStr | Cardiac muscle thin filament structures reveal calcium regulatory mechanism |
| title_full_unstemmed | Cardiac muscle thin filament structures reveal calcium regulatory mechanism |
| title_short | Cardiac muscle thin filament structures reveal calcium regulatory mechanism |
| title_sort | cardiac muscle thin filament structures reveal calcium regulatory mechanism |
| url | https://doi.org/10.1038/s41467-019-14008-1 |
| work_keys_str_mv | AT yurikayamada cardiacmusclethinfilamentstructuresrevealcalciumregulatorymechanism AT keiichinamba cardiacmusclethinfilamentstructuresrevealcalciumregulatorymechanism AT takashifujii cardiacmusclethinfilamentstructuresrevealcalciumregulatorymechanism |