NOS3 894G>T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?
Background/Aims: We have previously associated SNP 894G>T in the NOS3 gene with diabetic nephropathy (DN) using multi-locus analysis. Variant 894G>T has been widely studied as a DN susceptibility factor with contradictory results. In the present study we genotyped 894G>T in the cohort of pr...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2014-02-01
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| Series: | Kidney & Blood Pressure Research |
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| Online Access: | http://www.karger.com/Article/FullText/355757 |
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| author | Katarína Kuricová Veronika Tanhäuserová Lukáš Pácal Vendula Bartáková Lucie Brožová Jiří Jarkovský Kateřina Kaňková |
| author_facet | Katarína Kuricová Veronika Tanhäuserová Lukáš Pácal Vendula Bartáková Lucie Brožová Jiří Jarkovský Kateřina Kaňková |
| author_sort | Katarína Kuricová |
| collection | DOAJ |
| description | Background/Aims: We have previously associated SNP 894G>T in the NOS3 gene with diabetic nephropathy (DN) using multi-locus analysis. Variant 894G>T has been widely studied as a DN susceptibility factor with contradictory results. In the present study we genotyped 894G>T in the cohort of prospectively followed type 2 diabetics with the aim to investigate its possible role in the progression of DN and development of morbidity and mortality associated with diabetes. Methods: 311 subjects with defined stage of DN were enrolled in the study and followed up for a median of 38 months. We considered three end-points: progression of DN, major cardiovascular event and all-cause mortality. Results: Considering baseline GFR, age at enrolment and diabetes duration as confounders, Cox regression analysis identified 894GT genotype as a risk factor for DN progression (HR = 1.843 [95% CI 1.088 - 3.119], P = 0.023) and 894TT genotype as a risk factor for major cardiovascular event (HR = 2.515 [95% CI 1.060 - 5.965], P = 0.036). Conclusion: We ascertained the significant effect of the NOS3 894G>T variant on DN progression and occurrence of major cardiovascular event in T2DM subjects. Based on these results NOS3 can be considered a modifier gene for DN. |
| first_indexed | 2024-12-10T21:23:26Z |
| format | Article |
| id | doaj.art-e4c14bae9e6b466f9f0669b61f72d7f2 |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-12-10T21:23:26Z |
| publishDate | 2014-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-e4c14bae9e6b466f9f0669b61f72d7f22022-12-22T01:33:03ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432014-02-01381929810.1159/000355757355757NOS3 894G>T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?Katarína KuricováVeronika TanhäuserováLukáš PácalVendula BartákováLucie BrožováJiří JarkovskýKateřina KaňkováBackground/Aims: We have previously associated SNP 894G>T in the NOS3 gene with diabetic nephropathy (DN) using multi-locus analysis. Variant 894G>T has been widely studied as a DN susceptibility factor with contradictory results. In the present study we genotyped 894G>T in the cohort of prospectively followed type 2 diabetics with the aim to investigate its possible role in the progression of DN and development of morbidity and mortality associated with diabetes. Methods: 311 subjects with defined stage of DN were enrolled in the study and followed up for a median of 38 months. We considered three end-points: progression of DN, major cardiovascular event and all-cause mortality. Results: Considering baseline GFR, age at enrolment and diabetes duration as confounders, Cox regression analysis identified 894GT genotype as a risk factor for DN progression (HR = 1.843 [95% CI 1.088 - 3.119], P = 0.023) and 894TT genotype as a risk factor for major cardiovascular event (HR = 2.515 [95% CI 1.060 - 5.965], P = 0.036). Conclusion: We ascertained the significant effect of the NOS3 894G>T variant on DN progression and occurrence of major cardiovascular event in T2DM subjects. Based on these results NOS3 can be considered a modifier gene for DN.http://www.karger.com/Article/FullText/355757PolymorphismCardiovascular morbidityDiabetic nephropathyNitric oxide synthase |
| spellingShingle | Katarína Kuricová Veronika Tanhäuserová Lukáš Pácal Vendula Bartáková Lucie Brožová Jiří Jarkovský Kateřina Kaňková NOS3 894G>T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy? Kidney & Blood Pressure Research Polymorphism Cardiovascular morbidity Diabetic nephropathy Nitric oxide synthase |
| title | NOS3 894G>T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy? |
| title_full | NOS3 894G>T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy? |
| title_fullStr | NOS3 894G>T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy? |
| title_full_unstemmed | NOS3 894G>T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy? |
| title_short | NOS3 894G>T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy? |
| title_sort | nos3 894g t polymorphism is associated with progression of kidney disease and cardiovascular morbidity in type 2 diabetic patients nos3 as a modifier gene for diabetic nephropathy |
| topic | Polymorphism Cardiovascular morbidity Diabetic nephropathy Nitric oxide synthase |
| url | http://www.karger.com/Article/FullText/355757 |
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