Three rounds (1R/2R/3R) of genome duplications and the evolution of the glycolytic pathway in vertebrates
<p>Abstract</p> <p>Background</p> <p>Evolution of the deuterostome lineage was accompanied by an increase in systematic complexity especially with regard to highly specialized tissues and organs. Based on the observation of an increased number of paralogous genes in ver...
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| Format: | Article |
| Language: | English |
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BMC
2006-06-01
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| Series: | BMC Biology |
| Online Access: | http://www.biomedcentral.com/1741-7007/4/16 |
| _version_ | 1818145513452601344 |
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| author | Hoegg Simone Steinke Dirk Brinkmann Henner Meyer Axel |
| author_facet | Hoegg Simone Steinke Dirk Brinkmann Henner Meyer Axel |
| author_sort | Hoegg Simone |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Evolution of the deuterostome lineage was accompanied by an increase in systematic complexity especially with regard to highly specialized tissues and organs. Based on the observation of an increased number of paralogous genes in vertebrates compared with invertebrates, two entire genome duplications (2R) were proposed during the early evolution of vertebrates. Most glycolytic enzymes occur as several copies in vertebrate genomes, which are specifically expressed in certain tissues. Therefore, the glycolytic pathway is particularly suitable for testing theories of the involvement of gene/genome duplications in enzyme evolution.</p> <p>Results</p> <p>We assembled datasets from genomic databases of at least nine vertebrate species and at least three outgroups (one deuterostome and two protostomes), and used maximum likelihood and Bayesian methods to construct phylogenies of the 10 enzymes of the glycolytic pathway. Through this approach, we intended to gain insights into the vertebrate specific evolution of enzymes of the glycolytic pathway. Many of the obtained gene trees generally reflect the history of two rounds of duplication during vertebrate evolution, and were in agreement with the hypothesis of an additional duplication event within the lineage of teleost fish. The retention of paralogs differed greatly between genes, and no direct link to the multimeric structure of the active enzyme was found.</p> <p>Conclusion</p> <p>The glycolytic pathway has subsequently evolved by gene duplication and divergence of each constituent enzyme with taxon-specific individual gene losses or lineage-specific duplications. The tissue-specific expression might have led to an increased retention for some genes since paralogs can subdivide the ancestral expression domain or find new functions, which are not necessarily related to the original function.</p> |
| first_indexed | 2024-12-11T12:04:39Z |
| format | Article |
| id | doaj.art-e4c1d02bb34448d9af0da7cac829cdc4 |
| institution | Directory Open Access Journal |
| issn | 1741-7007 |
| language | English |
| last_indexed | 2024-12-11T12:04:39Z |
| publishDate | 2006-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj.art-e4c1d02bb34448d9af0da7cac829cdc42022-12-22T01:07:58ZengBMCBMC Biology1741-70072006-06-01411610.1186/1741-7007-4-16Three rounds (1R/2R/3R) of genome duplications and the evolution of the glycolytic pathway in vertebratesHoegg SimoneSteinke DirkBrinkmann HennerMeyer Axel<p>Abstract</p> <p>Background</p> <p>Evolution of the deuterostome lineage was accompanied by an increase in systematic complexity especially with regard to highly specialized tissues and organs. Based on the observation of an increased number of paralogous genes in vertebrates compared with invertebrates, two entire genome duplications (2R) were proposed during the early evolution of vertebrates. Most glycolytic enzymes occur as several copies in vertebrate genomes, which are specifically expressed in certain tissues. Therefore, the glycolytic pathway is particularly suitable for testing theories of the involvement of gene/genome duplications in enzyme evolution.</p> <p>Results</p> <p>We assembled datasets from genomic databases of at least nine vertebrate species and at least three outgroups (one deuterostome and two protostomes), and used maximum likelihood and Bayesian methods to construct phylogenies of the 10 enzymes of the glycolytic pathway. Through this approach, we intended to gain insights into the vertebrate specific evolution of enzymes of the glycolytic pathway. Many of the obtained gene trees generally reflect the history of two rounds of duplication during vertebrate evolution, and were in agreement with the hypothesis of an additional duplication event within the lineage of teleost fish. The retention of paralogs differed greatly between genes, and no direct link to the multimeric structure of the active enzyme was found.</p> <p>Conclusion</p> <p>The glycolytic pathway has subsequently evolved by gene duplication and divergence of each constituent enzyme with taxon-specific individual gene losses or lineage-specific duplications. The tissue-specific expression might have led to an increased retention for some genes since paralogs can subdivide the ancestral expression domain or find new functions, which are not necessarily related to the original function.</p>http://www.biomedcentral.com/1741-7007/4/16 |
| spellingShingle | Hoegg Simone Steinke Dirk Brinkmann Henner Meyer Axel Three rounds (1R/2R/3R) of genome duplications and the evolution of the glycolytic pathway in vertebrates BMC Biology |
| title | Three rounds (1R/2R/3R) of genome duplications and the evolution of the glycolytic pathway in vertebrates |
| title_full | Three rounds (1R/2R/3R) of genome duplications and the evolution of the glycolytic pathway in vertebrates |
| title_fullStr | Three rounds (1R/2R/3R) of genome duplications and the evolution of the glycolytic pathway in vertebrates |
| title_full_unstemmed | Three rounds (1R/2R/3R) of genome duplications and the evolution of the glycolytic pathway in vertebrates |
| title_short | Three rounds (1R/2R/3R) of genome duplications and the evolution of the glycolytic pathway in vertebrates |
| title_sort | three rounds 1r 2r 3r of genome duplications and the evolution of the glycolytic pathway in vertebrates |
| url | http://www.biomedcentral.com/1741-7007/4/16 |
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