Investigation of the relationship between serum irisin level in the idiopathic restless legs syndrome: Could be a marker independent of physical activity?
Abstract Introduction Restless legs syndrome (RLS) is a common but underdiagnosed neurological syndrome. It is characterized by the feeling of discomfort and desire to move, especially in the lower extremities, which often occurs at night, and the cure or relief of symptoms with movement. Irisin is...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-07-01
|
| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.3100 |
| _version_ | 1797782029292535808 |
|---|---|
| author | Sena Boncuk Ulaş Türkan Acar Bilgehan Atılgan Acar Semra Alaçam Köksal Yeşim Güzey Aras Aybala Neslihan Alagöz Sıdıka Sinem Gül Nimet Uçaroğlu Can Mehmet Köroğlu |
| author_facet | Sena Boncuk Ulaş Türkan Acar Bilgehan Atılgan Acar Semra Alaçam Köksal Yeşim Güzey Aras Aybala Neslihan Alagöz Sıdıka Sinem Gül Nimet Uçaroğlu Can Mehmet Köroğlu |
| author_sort | Sena Boncuk Ulaş |
| collection | DOAJ |
| description | Abstract Introduction Restless legs syndrome (RLS) is a common but underdiagnosed neurological syndrome. It is characterized by the feeling of discomfort and desire to move, especially in the lower extremities, which often occurs at night, and the cure or relief of symptoms with movement. Irisin is a hormonelike polypeptide that was first identified in 2012, weighs 22 kDa, consists of 163 amino acids, and is mainly synthesized in muscle. Its synthesis increases with exercise. Here in this study, we planned to investigate the relationship among serum irisin level, physical activity, lipid profile, and RLS. Material and methods A total of 35 patients with idiopathic RLS and 35 volunteers were included in the study. Then, venous blood was taken from the participants in the morning after 12 h of night fasting. Results The mean value of serum irisin level was 16.9 ± 14.1 ng/mL in the case group and 5.1 ± 5.9 ng/mL in the control group, which was statistically quite significant (p < .001). A significant efficiency (under the curve area 0.886 [0.804–0.967]) of irisin value was observed in the differentiation of patients in the case and control groups. Discussion Serum irisin level was significantly higher in the case group than in the control group. In conclusion, we suggest that irisin may play a role in the pathophysiology of RLS independently of the intensity and duration of physical activity and anthropometric data, such as body weight, body mass index, and waist/hip ratio. |
| first_indexed | 2024-03-13T00:05:17Z |
| format | Article |
| id | doaj.art-e4c7b77906f9431b9f241aecc3e76977 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-13T00:05:17Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-e4c7b77906f9431b9f241aecc3e769772023-07-13T04:43:16ZengWileyBrain and Behavior2162-32792023-07-01137n/an/a10.1002/brb3.3100Investigation of the relationship between serum irisin level in the idiopathic restless legs syndrome: Could be a marker independent of physical activity?Sena Boncuk Ulaş0Türkan Acar1Bilgehan Atılgan Acar2Semra Alaçam Köksal3Yeşim Güzey Aras4Aybala Neslihan Alagöz5Sıdıka Sinem Gül6Nimet Uçaroğlu Can7Mehmet Köroğlu8Department of Neurology Keşan State Hospital Edirne TurkeyDepartment of Neurology Sakarya University Faculty of Medicine Sakarya TurkeyDepartment of Neurology Sakarya University Faculty of Medicine Sakarya TurkeyDepartment of Neurology Kocaeli İzmit SEKA State Hospital Kocaeli TurkeyDepartment of Neurology Sakarya University Faculty of Medicine Sakarya TurkeyDepartment of Neurology Kocaeli University Faculty of Medicine Kocaeli TurkeyDepartment of Neurology Yenikent State Hospital Sakarya TurkeyDepartment of Neurology Sakarya University Training and Research Hospital Sakarya TurkeyDepartment of Microbiology Sakarya University Faculty of Medicine Sakarya TurkeyAbstract Introduction Restless legs syndrome (RLS) is a common but underdiagnosed neurological syndrome. It is characterized by the feeling of discomfort and desire to move, especially in the lower extremities, which often occurs at night, and the cure or relief of symptoms with movement. Irisin is a hormonelike polypeptide that was first identified in 2012, weighs 22 kDa, consists of 163 amino acids, and is mainly synthesized in muscle. Its synthesis increases with exercise. Here in this study, we planned to investigate the relationship among serum irisin level, physical activity, lipid profile, and RLS. Material and methods A total of 35 patients with idiopathic RLS and 35 volunteers were included in the study. Then, venous blood was taken from the participants in the morning after 12 h of night fasting. Results The mean value of serum irisin level was 16.9 ± 14.1 ng/mL in the case group and 5.1 ± 5.9 ng/mL in the control group, which was statistically quite significant (p < .001). A significant efficiency (under the curve area 0.886 [0.804–0.967]) of irisin value was observed in the differentiation of patients in the case and control groups. Discussion Serum irisin level was significantly higher in the case group than in the control group. In conclusion, we suggest that irisin may play a role in the pathophysiology of RLS independently of the intensity and duration of physical activity and anthropometric data, such as body weight, body mass index, and waist/hip ratio.https://doi.org/10.1002/brb3.3100irisinphysical activityrestless legs syndrome |
| spellingShingle | Sena Boncuk Ulaş Türkan Acar Bilgehan Atılgan Acar Semra Alaçam Köksal Yeşim Güzey Aras Aybala Neslihan Alagöz Sıdıka Sinem Gül Nimet Uçaroğlu Can Mehmet Köroğlu Investigation of the relationship between serum irisin level in the idiopathic restless legs syndrome: Could be a marker independent of physical activity? Brain and Behavior irisin physical activity restless legs syndrome |
| title | Investigation of the relationship between serum irisin level in the idiopathic restless legs syndrome: Could be a marker independent of physical activity? |
| title_full | Investigation of the relationship between serum irisin level in the idiopathic restless legs syndrome: Could be a marker independent of physical activity? |
| title_fullStr | Investigation of the relationship between serum irisin level in the idiopathic restless legs syndrome: Could be a marker independent of physical activity? |
| title_full_unstemmed | Investigation of the relationship between serum irisin level in the idiopathic restless legs syndrome: Could be a marker independent of physical activity? |
| title_short | Investigation of the relationship between serum irisin level in the idiopathic restless legs syndrome: Could be a marker independent of physical activity? |
| title_sort | investigation of the relationship between serum irisin level in the idiopathic restless legs syndrome could be a marker independent of physical activity |
| topic | irisin physical activity restless legs syndrome |
| url | https://doi.org/10.1002/brb3.3100 |
| work_keys_str_mv | AT senaboncukulas investigationoftherelationshipbetweenserumirisinlevelintheidiopathicrestlesslegssyndromecouldbeamarkerindependentofphysicalactivity AT turkanacar investigationoftherelationshipbetweenserumirisinlevelintheidiopathicrestlesslegssyndromecouldbeamarkerindependentofphysicalactivity AT bilgehanatılganacar investigationoftherelationshipbetweenserumirisinlevelintheidiopathicrestlesslegssyndromecouldbeamarkerindependentofphysicalactivity AT semraalacamkoksal investigationoftherelationshipbetweenserumirisinlevelintheidiopathicrestlesslegssyndromecouldbeamarkerindependentofphysicalactivity AT yesimguzeyaras investigationoftherelationshipbetweenserumirisinlevelintheidiopathicrestlesslegssyndromecouldbeamarkerindependentofphysicalactivity AT aybalaneslihanalagoz investigationoftherelationshipbetweenserumirisinlevelintheidiopathicrestlesslegssyndromecouldbeamarkerindependentofphysicalactivity AT sıdıkasinemgul investigationoftherelationshipbetweenserumirisinlevelintheidiopathicrestlesslegssyndromecouldbeamarkerindependentofphysicalactivity AT nimetucaroglucan investigationoftherelationshipbetweenserumirisinlevelintheidiopathicrestlesslegssyndromecouldbeamarkerindependentofphysicalactivity AT mehmetkoroglu investigationoftherelationshipbetweenserumirisinlevelintheidiopathicrestlesslegssyndromecouldbeamarkerindependentofphysicalactivity |