Efficiency of the green formulated iron nanoparticles as a new tool in lung cancer therapy
In the recent study, we described a novel iron nanoparticles green-mediated by arabic coffee as a novel anticancer agent (FeNPs). The recent nanoparticles were analyzed by Fourier transformed infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), transmission electron mi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535223003908 |
| _version_ | 1797804028917186560 |
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| author | Hanchen Ma Chaochao Wang Xiuwen Li Dongxin Sui Shaohua Xu |
| author_facet | Hanchen Ma Chaochao Wang Xiuwen Li Dongxin Sui Shaohua Xu |
| author_sort | Hanchen Ma |
| collection | DOAJ |
| description | In the recent study, we described a novel iron nanoparticles green-mediated by arabic coffee as a novel anticancer agent (FeNPs). The recent nanoparticles were analyzed by Fourier transformed infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), elemental mapping, X-ray diffraction (XRD) and ultraviolet–visible spectroscopy (UV–Vis). The iron nanoparticles showed the best antioxidant activities against DPPH. The IC50 of iron nanoparticles and BHT against DPPH free radicals were 165 and 62 µg/mL, respectively. In the oncological part of the recent study, the treated cells with iron nanoparticles were assessed by MTT assay for 48 h about the cytotoxicity and anticancer properties on normal (HUVEC) and lung cancer cell lines. The IC50 of iron nanoparticles were 273, 216, and 250 µg/mL against HT144, SKMEL2, and WM266-4 cell lines, respectively. The viability of malignant cell lines reduced dose-dependently in the presence of iron nanoparticles. |
| first_indexed | 2024-03-13T05:29:57Z |
| format | Article |
| id | doaj.art-e4c886477e1f40b583c6b9c750ddb8ae |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-03-13T05:29:57Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-e4c886477e1f40b583c6b9c750ddb8ae2023-06-15T04:54:57ZengElsevierArabian Journal of Chemistry1878-53522023-08-01168104928Efficiency of the green formulated iron nanoparticles as a new tool in lung cancer therapyHanchen Ma0Chaochao Wang1Xiuwen Li2Dongxin Sui3Shaohua Xu4Department of Respiratory and Critical Care Medicine, The Second Hospital of Shandong University, No. 247, Beiyuan Road, Shandong Province, 250033, Jinan City, ChinaDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Shandong University, No. 247, Beiyuan Road, Shandong Province, 250033, Jinan City, ChinaDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Shandong University, No. 247, Beiyuan Road, Shandong Province, 250033, Jinan City, ChinaDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Shandong University, No. 247, Beiyuan Road, Shandong Province, 250033, Jinan City, ChinaCorresponding author.; Department of Respiratory and Critical Care Medicine, The Second Hospital of Shandong University, No. 247, Beiyuan Road, Shandong Province, 250033, Jinan City, ChinaIn the recent study, we described a novel iron nanoparticles green-mediated by arabic coffee as a novel anticancer agent (FeNPs). The recent nanoparticles were analyzed by Fourier transformed infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), elemental mapping, X-ray diffraction (XRD) and ultraviolet–visible spectroscopy (UV–Vis). The iron nanoparticles showed the best antioxidant activities against DPPH. The IC50 of iron nanoparticles and BHT against DPPH free radicals were 165 and 62 µg/mL, respectively. In the oncological part of the recent study, the treated cells with iron nanoparticles were assessed by MTT assay for 48 h about the cytotoxicity and anticancer properties on normal (HUVEC) and lung cancer cell lines. The IC50 of iron nanoparticles were 273, 216, and 250 µg/mL against HT144, SKMEL2, and WM266-4 cell lines, respectively. The viability of malignant cell lines reduced dose-dependently in the presence of iron nanoparticles.http://www.sciencedirect.com/science/article/pii/S1878535223003908Arabic coffeeIron nanoparticlesAnticancerCytotoxicity |
| spellingShingle | Hanchen Ma Chaochao Wang Xiuwen Li Dongxin Sui Shaohua Xu Efficiency of the green formulated iron nanoparticles as a new tool in lung cancer therapy Arabian Journal of Chemistry Arabic coffee Iron nanoparticles Anticancer Cytotoxicity |
| title | Efficiency of the green formulated iron nanoparticles as a new tool in lung cancer therapy |
| title_full | Efficiency of the green formulated iron nanoparticles as a new tool in lung cancer therapy |
| title_fullStr | Efficiency of the green formulated iron nanoparticles as a new tool in lung cancer therapy |
| title_full_unstemmed | Efficiency of the green formulated iron nanoparticles as a new tool in lung cancer therapy |
| title_short | Efficiency of the green formulated iron nanoparticles as a new tool in lung cancer therapy |
| title_sort | efficiency of the green formulated iron nanoparticles as a new tool in lung cancer therapy |
| topic | Arabic coffee Iron nanoparticles Anticancer Cytotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S1878535223003908 |
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