Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine
Abstract Complete regeneration of damaged tissues/organs has always been the ultimate challenge in regenerative medicine. Aging has long been considered the basis of age‐related diseases, as senescent cells gradually accumulate in tissues with increasing age, tissues exhibit aging and normal physiol...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-11-01
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| Series: | Smart Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/SMMD.20230030 |
| _version_ | 1797372820848640000 |
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| author | Qianyi Li Zhenzhen Wang Nuo Shi Yang Qi Wenfei Yao Jie Yu Yiming Lu |
| author_facet | Qianyi Li Zhenzhen Wang Nuo Shi Yang Qi Wenfei Yao Jie Yu Yiming Lu |
| author_sort | Qianyi Li |
| collection | DOAJ |
| description | Abstract Complete regeneration of damaged tissues/organs has always been the ultimate challenge in regenerative medicine. Aging has long been considered the basis of age‐related diseases, as senescent cells gradually accumulate in tissues with increasing age, tissues exhibit aging and normal physiological functions are inhibited. In recent years, in damaged tissues, scholars have found that the number of cells with features of cellular senescence continues to increase over time. The accumulation of senescent cells severely hinders the healing of damaged tissues. Furthermore, by clearing senescent cells or inhibiting the aging microenvironment, damaged tissues regained their original regenerative and repair capabilities. On the other hand, various biomaterials have been proved to have good biocompatibility and can effectively support cell regeneration after injury. Combining the two solutions, inhibiting the cellular senescence in damaged tissues and establishing a pro‐regenerative environment through biomaterial technology gradually reveals a new, unexpected treatment strategy applied to the field of regenerative medicine. In this review, we first elucidate the main characteristics of senescent cells from morphological, functional and molecular levels, and discuss in detail the process of accumulation of senescent cells in tissues. Then, we will explore in depth how the accumulation of senescent cells after damage affects tissue repair and regeneration at different stages. Finally, we will turn to how to promote tissue regeneration and repair in the field of regenerative medicine by inhibiting cellular senescence combined with biomaterial technology. Our goal is to understand the relationship between cellular senescence and tissue regeneration through this new perspective, and provide valuable references for the development of new therapeutic strategies in the future. |
| first_indexed | 2024-03-08T18:40:22Z |
| format | Article |
| id | doaj.art-e4c88b784e9d452aa13021f4e57009a3 |
| institution | Directory Open Access Journal |
| issn | 2751-1871 |
| language | English |
| last_indexed | 2024-03-08T18:40:22Z |
| publishDate | 2023-11-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Smart Medicine |
| spelling | doaj.art-e4c88b784e9d452aa13021f4e57009a32023-12-29T08:08:00ZengWiley-VCHSmart Medicine2751-18712023-11-0124n/an/a10.1002/SMMD.20230030Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicineQianyi Li0Zhenzhen Wang1Nuo Shi2Yang Qi3Wenfei Yao4Jie Yu5Yiming Lu6Department of Emergency Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaPeterson's Lab Shanghai ChinaPeterson's Lab Shanghai ChinaDepartment of Emergency Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Emergency Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Emergency Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Emergency Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaAbstract Complete regeneration of damaged tissues/organs has always been the ultimate challenge in regenerative medicine. Aging has long been considered the basis of age‐related diseases, as senescent cells gradually accumulate in tissues with increasing age, tissues exhibit aging and normal physiological functions are inhibited. In recent years, in damaged tissues, scholars have found that the number of cells with features of cellular senescence continues to increase over time. The accumulation of senescent cells severely hinders the healing of damaged tissues. Furthermore, by clearing senescent cells or inhibiting the aging microenvironment, damaged tissues regained their original regenerative and repair capabilities. On the other hand, various biomaterials have been proved to have good biocompatibility and can effectively support cell regeneration after injury. Combining the two solutions, inhibiting the cellular senescence in damaged tissues and establishing a pro‐regenerative environment through biomaterial technology gradually reveals a new, unexpected treatment strategy applied to the field of regenerative medicine. In this review, we first elucidate the main characteristics of senescent cells from morphological, functional and molecular levels, and discuss in detail the process of accumulation of senescent cells in tissues. Then, we will explore in depth how the accumulation of senescent cells after damage affects tissue repair and regeneration at different stages. Finally, we will turn to how to promote tissue regeneration and repair in the field of regenerative medicine by inhibiting cellular senescence combined with biomaterial technology. Our goal is to understand the relationship between cellular senescence and tissue regeneration through this new perspective, and provide valuable references for the development of new therapeutic strategies in the future.https://doi.org/10.1002/SMMD.20230030aging and regenerationcell senescencesenolytics and senomorphicstissue engineering |
| spellingShingle | Qianyi Li Zhenzhen Wang Nuo Shi Yang Qi Wenfei Yao Jie Yu Yiming Lu Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine Smart Medicine aging and regeneration cell senescence senolytics and senomorphics tissue engineering |
| title | Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine |
| title_full | Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine |
| title_fullStr | Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine |
| title_full_unstemmed | Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine |
| title_short | Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine |
| title_sort | application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro regenerative biomaterials in regenerative medicine |
| topic | aging and regeneration cell senescence senolytics and senomorphics tissue engineering |
| url | https://doi.org/10.1002/SMMD.20230030 |
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