Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives
The great majority of breast and prostate tumors are hormone-dependent cancers; hence, estrogens and androgens can, respectively, drive their developments, making it possible to use pharmacological therapies in their hormone-dependent phases by targeting the levels of steroid or modulating their phy...
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/10/3690 |
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| author | Bagora Bayala Abdou Azaque Zoure Silvère Baron Cyrille de Joussineau Jacques Simpore Jean-Marc A. Lobaccaro |
| author_facet | Bagora Bayala Abdou Azaque Zoure Silvère Baron Cyrille de Joussineau Jacques Simpore Jean-Marc A. Lobaccaro |
| author_sort | Bagora Bayala |
| collection | DOAJ |
| description | The great majority of breast and prostate tumors are hormone-dependent cancers; hence, estrogens and androgens can, respectively, drive their developments, making it possible to use pharmacological therapies in their hormone-dependent phases by targeting the levels of steroid or modulating their physiological activity through their respective nuclear receptors when the tumors relapse. Unfortunately, at some stage, both breast and prostate cancers become resistant to pharmacological treatments that aim to block their receptors, estrogen (ER) or androgen (AR) receptors, respectively. So far, antiestrogens and antiandrogens used in clinics have been designed based on their structural analogies with natural hormones, 17-β estradiol and dihydrotestosterone. Plants are a potential source of drug discovery and the development of new pharmacological compounds. The aim of this review article is to highlight the recent advances in the pharmacological modulation of androgen or estrogen levels, and their activity through their cognate nuclear receptors in prostate or breast cancer and the effects of some plants extracts. |
| first_indexed | 2024-03-10T19:38:09Z |
| format | Article |
| id | doaj.art-e4c89543ae354cf3ae4cf0ec29add736 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:38:09Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e4c89543ae354cf3ae4cf0ec29add7362023-11-20T01:32:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-012110369010.3390/ijms21103690Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract DerivativesBagora Bayala0Abdou Azaque Zoure1Silvère Baron2Cyrille de Joussineau3Jacques Simpore4Jean-Marc A. Lobaccaro5Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina FasoLaboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina FasoUniversité Clermont Auvergne, CNRS, Inserm, GReD, F-63000 Clermont-Ferrand, FranceUniversité Clermont Auvergne, CNRS, Inserm, GReD, F-63000 Clermont-Ferrand, FranceLaboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina FasoUniversité Clermont Auvergne, CNRS, Inserm, GReD, F-63000 Clermont-Ferrand, FranceThe great majority of breast and prostate tumors are hormone-dependent cancers; hence, estrogens and androgens can, respectively, drive their developments, making it possible to use pharmacological therapies in their hormone-dependent phases by targeting the levels of steroid or modulating their physiological activity through their respective nuclear receptors when the tumors relapse. Unfortunately, at some stage, both breast and prostate cancers become resistant to pharmacological treatments that aim to block their receptors, estrogen (ER) or androgen (AR) receptors, respectively. So far, antiestrogens and antiandrogens used in clinics have been designed based on their structural analogies with natural hormones, 17-β estradiol and dihydrotestosterone. Plants are a potential source of drug discovery and the development of new pharmacological compounds. The aim of this review article is to highlight the recent advances in the pharmacological modulation of androgen or estrogen levels, and their activity through their cognate nuclear receptors in prostate or breast cancer and the effects of some plants extracts.https://www.mdpi.com/1422-0067/21/10/3690nuclear receptorshormone-dependent tumorsprostate and breast cancersplant extract derivativessteroids |
| spellingShingle | Bagora Bayala Abdou Azaque Zoure Silvère Baron Cyrille de Joussineau Jacques Simpore Jean-Marc A. Lobaccaro Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives International Journal of Molecular Sciences nuclear receptors hormone-dependent tumors prostate and breast cancers plant extract derivatives steroids |
| title | Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives |
| title_full | Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives |
| title_fullStr | Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives |
| title_full_unstemmed | Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives |
| title_short | Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives |
| title_sort | pharmacological modulation of steroid activity in hormone dependent breast and prostate cancers effect of some plant extract derivatives |
| topic | nuclear receptors hormone-dependent tumors prostate and breast cancers plant extract derivatives steroids |
| url | https://www.mdpi.com/1422-0067/21/10/3690 |
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