Anti--methyl-D-aspartate receptor encephalitis in a young female with subclinical hypothyroidism associated with anti-thyroid peroxidase and anti-thyroglobulin antibodies: A case report
Anti- N -methyl-D-aspartate receptor encephalitis is a life-threatening medical emergency that can be clinically misperceived as Hashimoto’s encephalopathy. We present a case of anti- N -methyl-D-aspartate receptor encephalitis in an otherwise healthy young female with subclinical hypothyroidism wit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-08-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X20949780 |
| _version_ | 1818195363769614336 |
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| author | Mohamed Adil Shah Khoodoruth Widaad Nuzhah Chut-kai Khoodoruth Mahmoud Khalil Mahmoud Alshawwaf |
| author_facet | Mohamed Adil Shah Khoodoruth Widaad Nuzhah Chut-kai Khoodoruth Mahmoud Khalil Mahmoud Alshawwaf |
| author_sort | Mohamed Adil Shah Khoodoruth |
| collection | DOAJ |
| description | Anti- N -methyl-D-aspartate receptor encephalitis is a life-threatening medical emergency that can be clinically misperceived as Hashimoto’s encephalopathy. We present a case of anti- N -methyl-D-aspartate receptor encephalitis in an otherwise healthy young female with subclinical hypothyroidism without an associated ovarian teratoma. She was first misdiagnosed as Hashimoto’s encephalopathy due to delirium and behavioral changes, seizures, psychosis, and increased amount of thyroid peroxidase and thyroglobulin antibodies in serum. Final diagnosis was established by third week following presentation with the detection of anti- N -methyl-D-aspartate receptor antibodies in her cerebrospinal fluid. After treatment with intravenous immunoglobulin, methylprednisolone, and amisulpride, she recovered significantly with minimal sequelae at 3-week follow-up. |
| first_indexed | 2024-12-12T01:17:00Z |
| format | Article |
| id | doaj.art-e4ca586bf88f416c9e1c13c4fed233d7 |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-12-12T01:17:00Z |
| publishDate | 2020-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-e4ca586bf88f416c9e1c13c4fed233d72022-12-22T00:43:20ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2020-08-01810.1177/2050313X20949780Anti--methyl-D-aspartate receptor encephalitis in a young female with subclinical hypothyroidism associated with anti-thyroid peroxidase and anti-thyroglobulin antibodies: A case reportMohamed Adil Shah KhoodoruthWidaad Nuzhah Chut-kai KhoodoruthMahmoud Khalil Mahmoud AlshawwafAnti- N -methyl-D-aspartate receptor encephalitis is a life-threatening medical emergency that can be clinically misperceived as Hashimoto’s encephalopathy. We present a case of anti- N -methyl-D-aspartate receptor encephalitis in an otherwise healthy young female with subclinical hypothyroidism without an associated ovarian teratoma. She was first misdiagnosed as Hashimoto’s encephalopathy due to delirium and behavioral changes, seizures, psychosis, and increased amount of thyroid peroxidase and thyroglobulin antibodies in serum. Final diagnosis was established by third week following presentation with the detection of anti- N -methyl-D-aspartate receptor antibodies in her cerebrospinal fluid. After treatment with intravenous immunoglobulin, methylprednisolone, and amisulpride, she recovered significantly with minimal sequelae at 3-week follow-up.https://doi.org/10.1177/2050313X20949780 |
| spellingShingle | Mohamed Adil Shah Khoodoruth Widaad Nuzhah Chut-kai Khoodoruth Mahmoud Khalil Mahmoud Alshawwaf Anti--methyl-D-aspartate receptor encephalitis in a young female with subclinical hypothyroidism associated with anti-thyroid peroxidase and anti-thyroglobulin antibodies: A case report SAGE Open Medical Case Reports |
| title | Anti--methyl-D-aspartate receptor encephalitis in a young female with subclinical hypothyroidism associated with anti-thyroid peroxidase and anti-thyroglobulin antibodies: A case report |
| title_full | Anti--methyl-D-aspartate receptor encephalitis in a young female with subclinical hypothyroidism associated with anti-thyroid peroxidase and anti-thyroglobulin antibodies: A case report |
| title_fullStr | Anti--methyl-D-aspartate receptor encephalitis in a young female with subclinical hypothyroidism associated with anti-thyroid peroxidase and anti-thyroglobulin antibodies: A case report |
| title_full_unstemmed | Anti--methyl-D-aspartate receptor encephalitis in a young female with subclinical hypothyroidism associated with anti-thyroid peroxidase and anti-thyroglobulin antibodies: A case report |
| title_short | Anti--methyl-D-aspartate receptor encephalitis in a young female with subclinical hypothyroidism associated with anti-thyroid peroxidase and anti-thyroglobulin antibodies: A case report |
| title_sort | anti methyl d aspartate receptor encephalitis in a young female with subclinical hypothyroidism associated with anti thyroid peroxidase and anti thyroglobulin antibodies a case report |
| url | https://doi.org/10.1177/2050313X20949780 |
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