Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts

Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts

Abstract Despite several advances in the field, pharmacodynamic outcome measures reflective of LRRK2 kinase activity in clinical biofluids remain urgently needed. A variety of targets and approaches have been utilized including assessments of LRRK2 itself (levels, phosphorylation), or its substrates...

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Main Authors: Lilian Petropoulou-Vathi, Athina Simitsi, Politymi-Eleni Valkimadi, Maria Kedariti, Lampros Dimitrakopoulos, Christos Koros, Dimitra Papadimitriou, Alexandros Papadimitriou, Leonidas Stefanis, Roy N. Alcalay, Hardy J. Rideout
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-022-00336-5

Internet

https://doi.org/10.1038/s41531-022-00336-5

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