A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides
A new series of pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides were designed based on molecular hybridization approach and synthesized by reaction of benzohydrazide derivatives with 9-phenylfuro[3,4-b]quinoline-1,3-diones in the presence of an Et3N catalyst. Simple reaction, excellent yield, simple sepa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-10-01
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| Series: | Green Chemistry Letters and Reviews |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/17518253.2017.1380233 |
| Summary: | A new series of pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides were designed based on molecular hybridization approach and synthesized by reaction of benzohydrazide derivatives with 9-phenylfuro[3,4-b]quinoline-1,3-diones in the presence of an Et3N catalyst. Simple reaction, excellent yield, simple separation process and eco-friendly approach by minimizing the chemical waste renders this protocol particularly attractive. The series 9a–g was evaluated for in vitro antibacterial activity against (+ve bacteria) Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212, (−ve bacterium) Escherichia coli ATCC 25922. In vitro minimum inhibitory concentration (MIC) evaluations showed that the compound 9a was effective against E. coli (MIC: 0.25 mg/mL) S. aureus (MIC: 0.25 mg/mL) and E. faecalis (MIC: 0.5 mg/mL). |
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| ISSN: | 1751-8253 1751-7192 |