A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides
A new series of pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides were designed based on molecular hybridization approach and synthesized by reaction of benzohydrazide derivatives with 9-phenylfuro[3,4-b]quinoline-1,3-diones in the presence of an Et3N catalyst. Simple reaction, excellent yield, simple sepa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-10-01
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| Series: | Green Chemistry Letters and Reviews |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/17518253.2017.1380233 |
| _version_ | 1811273940521189376 |
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| author | Tahere Hosseyni Largani Gholamhassan Imanzadeh Saber Zahri Nader Noroozi Pesyan Ertan Şahin |
| author_facet | Tahere Hosseyni Largani Gholamhassan Imanzadeh Saber Zahri Nader Noroozi Pesyan Ertan Şahin |
| author_sort | Tahere Hosseyni Largani |
| collection | DOAJ |
| description | A new series of pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides were designed based on molecular hybridization approach and synthesized by reaction of benzohydrazide derivatives with 9-phenylfuro[3,4-b]quinoline-1,3-diones in the presence of an Et3N catalyst. Simple reaction, excellent yield, simple separation process and eco-friendly approach by minimizing the chemical waste renders this protocol particularly attractive. The series 9a–g was evaluated for in vitro antibacterial activity against (+ve bacteria) Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212, (−ve bacterium) Escherichia coli ATCC 25922. In vitro minimum inhibitory concentration (MIC) evaluations showed that the compound 9a was effective against E. coli (MIC: 0.25 mg/mL) S. aureus (MIC: 0.25 mg/mL) and E. faecalis (MIC: 0.5 mg/mL). |
| first_indexed | 2024-04-12T23:09:54Z |
| format | Article |
| id | doaj.art-e4cbf68b76584272a088ae2fc13b9c88 |
| institution | Directory Open Access Journal |
| issn | 1751-8253 1751-7192 |
| language | English |
| last_indexed | 2024-04-12T23:09:54Z |
| publishDate | 2017-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Green Chemistry Letters and Reviews |
| spelling | doaj.art-e4cbf68b76584272a088ae2fc13b9c882022-12-22T03:12:50ZengTaylor & Francis GroupGreen Chemistry Letters and Reviews1751-82531751-71922017-10-0110438739210.1080/17518253.2017.13802331380233A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamidesTahere Hosseyni Largani0Gholamhassan Imanzadeh1Saber Zahri2Nader Noroozi Pesyan3Ertan Şahin4University of Mohaghegh ArdabiliUniversity of Mohaghegh ArdabiliUniversity of Mohaghegh ArdabiliUrmia UniversityAtatürk UniversityA new series of pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides were designed based on molecular hybridization approach and synthesized by reaction of benzohydrazide derivatives with 9-phenylfuro[3,4-b]quinoline-1,3-diones in the presence of an Et3N catalyst. Simple reaction, excellent yield, simple separation process and eco-friendly approach by minimizing the chemical waste renders this protocol particularly attractive. The series 9a–g was evaluated for in vitro antibacterial activity against (+ve bacteria) Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212, (−ve bacterium) Escherichia coli ATCC 25922. In vitro minimum inhibitory concentration (MIC) evaluations showed that the compound 9a was effective against E. coli (MIC: 0.25 mg/mL) S. aureus (MIC: 0.25 mg/mL) and E. faecalis (MIC: 0.5 mg/mL).http://dx.doi.org/10.1080/17518253.2017.1380233Pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamidesmolecular hybridizationantibiotic resistanceminimum inhibitory concentrationeco-friendly approach |
| spellingShingle | Tahere Hosseyni Largani Gholamhassan Imanzadeh Saber Zahri Nader Noroozi Pesyan Ertan Şahin A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides Green Chemistry Letters and Reviews Pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides molecular hybridization antibiotic resistance minimum inhibitory concentration eco-friendly approach |
| title | A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides |
| title_full | A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides |
| title_fullStr | A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides |
| title_full_unstemmed | A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides |
| title_short | A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides |
| title_sort | facile synthesis and antibacterial activity of novel pyrrolo 3 4 b quinolin 2 3h yl benzamides |
| topic | Pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides molecular hybridization antibiotic resistance minimum inhibitory concentration eco-friendly approach |
| url | http://dx.doi.org/10.1080/17518253.2017.1380233 |
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