Outcomes of Definitive Chemoradiotherapy for Stage IVa (T4b vs. N4) Esophageal Squamous Cell Carcinoma Based on the Japanese Classification System: A Retrospective Single-Center Study
The differences in prognoses or progression patterns between T4b non-N4 and non-T4b N4 esophageal squamous cell carcinoma post chemoradiotherapy (CRT) is unclear. This study compared the outcomes of CRT for stage IVa esophageal squamous cell carcinoma according to T/N factors. We retrospectively ide...
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MDPI AG
2020-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/1/8 |
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| author | Yuki Wada Akira Anbai Noriko Takagi Satoshi Kumagai Eriko Okuyama Hiroshi Nanjo Yusuke Sato Satoru Motoyama Manabu Hashimoto |
| author_facet | Yuki Wada Akira Anbai Noriko Takagi Satoshi Kumagai Eriko Okuyama Hiroshi Nanjo Yusuke Sato Satoru Motoyama Manabu Hashimoto |
| author_sort | Yuki Wada |
| collection | DOAJ |
| description | The differences in prognoses or progression patterns between T4b non-N4 and non-T4b N4 esophageal squamous cell carcinoma post chemoradiotherapy (CRT) is unclear. This study compared the outcomes of CRT for stage IVa esophageal squamous cell carcinoma according to T/N factors. We retrospectively identified 66 patients with stage IVa esophageal squamous cell carcinoma who underwent definitive CRT at our center between January 2009 and March 2013. The treatment outcomes, i.e., progression patterns, prognostic factors, and toxicities based on version 5.0 of the National Cancer Institute Common Terminology Criteria for Adverse Events, were studied. The patients (56 men and 10 women) had a median age of 67 (range: 37–87) years. The T/N classifications were T4b non-N4 (28/66), non-T4b N4 (24/66), and T4b N4 (14/66). Objective response was achieved in 57 patients (86.4%, (95% confidence interval, 74.6–94.1%)). There were no significant differences between the T/N groups in terms of overall survival, progression-free survival, and progression pattern. We found no significant differences in prognoses or progression patterns among patients with T4b non-N4, non-T4b N4, and T4b N4 esophageal squamous cell carcinoma. Thus, it seems impractical to modify CRT regimens based on T/N factors. |
| first_indexed | 2024-03-10T13:51:49Z |
| format | Article |
| id | doaj.art-e4cd3012b20342ebb1f7a17360dd3d56 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T13:51:49Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e4cd3012b20342ebb1f7a17360dd3d562023-11-21T02:06:35ZengMDPI AGCancers2072-66942020-12-01131810.3390/cancers13010008Outcomes of Definitive Chemoradiotherapy for Stage IVa (T4b vs. N4) Esophageal Squamous Cell Carcinoma Based on the Japanese Classification System: A Retrospective Single-Center StudyYuki Wada0Akira Anbai1Noriko Takagi2Satoshi Kumagai3Eriko Okuyama4Hiroshi Nanjo5Yusuke Sato6Satoru Motoyama7Manabu Hashimoto8Department of Radiology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8545, JapanDepartment of Radiology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8545, JapanDepartment of Radiology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8545, JapanDepartment of Radiology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8545, JapanDepartment of Radiology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8545, JapanDivision of Clinical Pathology, Akita University Hospital, 1-1-1 Hondo, Akita 010-8545, JapanEsophageal Surgery, Akita University Hospital, 1-1-1 Hondo, Akita 010-8545, JapanEsophageal Surgery, Akita University Hospital, 1-1-1 Hondo, Akita 010-8545, JapanDepartment of Radiology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8545, JapanThe differences in prognoses or progression patterns between T4b non-N4 and non-T4b N4 esophageal squamous cell carcinoma post chemoradiotherapy (CRT) is unclear. This study compared the outcomes of CRT for stage IVa esophageal squamous cell carcinoma according to T/N factors. We retrospectively identified 66 patients with stage IVa esophageal squamous cell carcinoma who underwent definitive CRT at our center between January 2009 and March 2013. The treatment outcomes, i.e., progression patterns, prognostic factors, and toxicities based on version 5.0 of the National Cancer Institute Common Terminology Criteria for Adverse Events, were studied. The patients (56 men and 10 women) had a median age of 67 (range: 37–87) years. The T/N classifications were T4b non-N4 (28/66), non-T4b N4 (24/66), and T4b N4 (14/66). Objective response was achieved in 57 patients (86.4%, (95% confidence interval, 74.6–94.1%)). There were no significant differences between the T/N groups in terms of overall survival, progression-free survival, and progression pattern. We found no significant differences in prognoses or progression patterns among patients with T4b non-N4, non-T4b N4, and T4b N4 esophageal squamous cell carcinoma. Thus, it seems impractical to modify CRT regimens based on T/N factors.https://www.mdpi.com/2072-6694/13/1/8esophageal squamous cell carcinomadefinitive chemoradiation therapyexternal beam radiation therapylocally advanced esophageal cancer |
| spellingShingle | Yuki Wada Akira Anbai Noriko Takagi Satoshi Kumagai Eriko Okuyama Hiroshi Nanjo Yusuke Sato Satoru Motoyama Manabu Hashimoto Outcomes of Definitive Chemoradiotherapy for Stage IVa (T4b vs. N4) Esophageal Squamous Cell Carcinoma Based on the Japanese Classification System: A Retrospective Single-Center Study Cancers esophageal squamous cell carcinoma definitive chemoradiation therapy external beam radiation therapy locally advanced esophageal cancer |
| title | Outcomes of Definitive Chemoradiotherapy for Stage IVa (T4b vs. N4) Esophageal Squamous Cell Carcinoma Based on the Japanese Classification System: A Retrospective Single-Center Study |
| title_full | Outcomes of Definitive Chemoradiotherapy for Stage IVa (T4b vs. N4) Esophageal Squamous Cell Carcinoma Based on the Japanese Classification System: A Retrospective Single-Center Study |
| title_fullStr | Outcomes of Definitive Chemoradiotherapy for Stage IVa (T4b vs. N4) Esophageal Squamous Cell Carcinoma Based on the Japanese Classification System: A Retrospective Single-Center Study |
| title_full_unstemmed | Outcomes of Definitive Chemoradiotherapy for Stage IVa (T4b vs. N4) Esophageal Squamous Cell Carcinoma Based on the Japanese Classification System: A Retrospective Single-Center Study |
| title_short | Outcomes of Definitive Chemoradiotherapy for Stage IVa (T4b vs. N4) Esophageal Squamous Cell Carcinoma Based on the Japanese Classification System: A Retrospective Single-Center Study |
| title_sort | outcomes of definitive chemoradiotherapy for stage iva t4b vs n4 esophageal squamous cell carcinoma based on the japanese classification system a retrospective single center study |
| topic | esophageal squamous cell carcinoma definitive chemoradiation therapy external beam radiation therapy locally advanced esophageal cancer |
| url | https://www.mdpi.com/2072-6694/13/1/8 |
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