A cost-effectiveness evaluation of latent tuberculosis infection screening of a migrant population in Malaysia
Abstract To estimate the costs and benefits of screening for latent tuberculosis infection (LTBI) in a migrant population in Malaysia. An economic model was developed from a Malaysian healthcare perspective to compare QuantiFERON-TB Gold Plus (QuantiFERON) with the tuberculin skin test (TST). A deci...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29648-z |
| _version_ | 1811165965555073024 |
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| author | Erin Barker Joe Moss Hayden Holmes Catherine Bowe Vinay Suryaprakash Riccardo Alagna Vladyslav Nikolayevskyy Marc Destito Davide Manissero |
| author_facet | Erin Barker Joe Moss Hayden Holmes Catherine Bowe Vinay Suryaprakash Riccardo Alagna Vladyslav Nikolayevskyy Marc Destito Davide Manissero |
| author_sort | Erin Barker |
| collection | DOAJ |
| description | Abstract To estimate the costs and benefits of screening for latent tuberculosis infection (LTBI) in a migrant population in Malaysia. An economic model was developed from a Malaysian healthcare perspective to compare QuantiFERON-TB Gold Plus (QuantiFERON) with the tuberculin skin test (TST). A decision tree was used to capture outcomes relating to LTBI screening followed by a Markov model that simulated the lifetime costs and benefits of the patient cohort. The Markov model did not capture the impact of secondary infections. The model included an R shiny interactive interface to allow adaptation to other scenarios and settings. QuantiFERON is both more effective and less costly than TST (dominant). Compared with QuantiFERON, the lifetime risk of developing active TB increases by approximately 40% for TST due to missed LTBI cases during screening (i.e. a higher number of false negative cases for TST). For a migrant population in Malaysia, QuantiFERON is cost-effective when compared with TST. Further research should consider targeted LTBI screening for migrants in Malaysia based on common risk factors. |
| first_indexed | 2024-04-10T15:45:49Z |
| format | Article |
| id | doaj.art-e4cd7afe957148e19f815bb34d8fec58 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T15:45:49Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e4cd7afe957148e19f815bb34d8fec582023-02-12T12:10:44ZengNature PortfolioScientific Reports2045-23222023-02-0113111110.1038/s41598-023-29648-zA cost-effectiveness evaluation of latent tuberculosis infection screening of a migrant population in MalaysiaErin Barker0Joe Moss1Hayden Holmes2Catherine Bowe3Vinay Suryaprakash4Riccardo Alagna5Vladyslav Nikolayevskyy6Marc Destito7Davide Manissero8York Health Economics Consortium, Enterprise House, Innovation Way, University of YorkYork Health Economics Consortium, Enterprise House, Innovation Way, University of YorkYork Health Economics Consortium, Enterprise House, Innovation Way, University of YorkYork Health Economics Consortium, Enterprise House, Innovation Way, University of YorkQIAGEN GmbHQIAGEN SRLQIAGEN ManchesterQIAGEN AGQIAGEN ManchesterAbstract To estimate the costs and benefits of screening for latent tuberculosis infection (LTBI) in a migrant population in Malaysia. An economic model was developed from a Malaysian healthcare perspective to compare QuantiFERON-TB Gold Plus (QuantiFERON) with the tuberculin skin test (TST). A decision tree was used to capture outcomes relating to LTBI screening followed by a Markov model that simulated the lifetime costs and benefits of the patient cohort. The Markov model did not capture the impact of secondary infections. The model included an R shiny interactive interface to allow adaptation to other scenarios and settings. QuantiFERON is both more effective and less costly than TST (dominant). Compared with QuantiFERON, the lifetime risk of developing active TB increases by approximately 40% for TST due to missed LTBI cases during screening (i.e. a higher number of false negative cases for TST). For a migrant population in Malaysia, QuantiFERON is cost-effective when compared with TST. Further research should consider targeted LTBI screening for migrants in Malaysia based on common risk factors.https://doi.org/10.1038/s41598-023-29648-z |
| spellingShingle | Erin Barker Joe Moss Hayden Holmes Catherine Bowe Vinay Suryaprakash Riccardo Alagna Vladyslav Nikolayevskyy Marc Destito Davide Manissero A cost-effectiveness evaluation of latent tuberculosis infection screening of a migrant population in Malaysia Scientific Reports |
| title | A cost-effectiveness evaluation of latent tuberculosis infection screening of a migrant population in Malaysia |
| title_full | A cost-effectiveness evaluation of latent tuberculosis infection screening of a migrant population in Malaysia |
| title_fullStr | A cost-effectiveness evaluation of latent tuberculosis infection screening of a migrant population in Malaysia |
| title_full_unstemmed | A cost-effectiveness evaluation of latent tuberculosis infection screening of a migrant population in Malaysia |
| title_short | A cost-effectiveness evaluation of latent tuberculosis infection screening of a migrant population in Malaysia |
| title_sort | cost effectiveness evaluation of latent tuberculosis infection screening of a migrant population in malaysia |
| url | https://doi.org/10.1038/s41598-023-29648-z |
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