Platelet and HIV Interactions and Their Contribution to Non-AIDS Comorbidities
Platelets are anucleate cytoplasmic cell fragments that circulate in the blood, where they are involved in regulating hemostasis. Beyond their normal physiologic role, platelets have emerged as versatile effectors of immune response. During an infection, cell surface receptors enable platelets to re...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/11/1608 |
| _version_ | 1827640465507221504 |
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| author | Thomas Awamura Elizabeth S. Nakasone Louie Mar Gangcuangco Natalie T. Subia Aeron-Justin Bali Dominic C. Chow Cecilia M. Shikuma Juwon Park |
| author_facet | Thomas Awamura Elizabeth S. Nakasone Louie Mar Gangcuangco Natalie T. Subia Aeron-Justin Bali Dominic C. Chow Cecilia M. Shikuma Juwon Park |
| author_sort | Thomas Awamura |
| collection | DOAJ |
| description | Platelets are anucleate cytoplasmic cell fragments that circulate in the blood, where they are involved in regulating hemostasis. Beyond their normal physiologic role, platelets have emerged as versatile effectors of immune response. During an infection, cell surface receptors enable platelets to recognize viruses, resulting in their activation. Activated platelets release biologically active molecules that further trigger host immune responses to protect the body against infection. Their impact on the immune response is also associated with the recruitment of circulating leukocytes to the site of infection. They can also aggregate with leukocytes, including lymphocytes, monocytes, and neutrophils, to immobilize pathogens and prevent viral dissemination. Despite their host protective role, platelets have also been shown to be associated with various pathophysiological processes. In this review, we will summarize platelet and HIV interactions during infection. We will also highlight and discuss platelet and platelet-derived mediators, how they interact with immune cells, and the multifaceted responsibilities of platelets in HIV infection. Furthermore, we will give an overview of non-AIDS comorbidities linked to platelet dysfunction and the impact of antiretroviral therapy on platelet function. |
| first_indexed | 2024-03-09T16:59:04Z |
| format | Article |
| id | doaj.art-e4cd956cefff4264b9df1794fb3e4e62 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T16:59:04Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-e4cd956cefff4264b9df1794fb3e4e622023-11-24T14:31:56ZengMDPI AGBiomolecules2218-273X2023-11-011311160810.3390/biom13111608Platelet and HIV Interactions and Their Contribution to Non-AIDS ComorbiditiesThomas Awamura0Elizabeth S. Nakasone1Louie Mar Gangcuangco2Natalie T. Subia3Aeron-Justin Bali4Dominic C. Chow5Cecilia M. Shikuma6Juwon Park7Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School Medicine, University of Hawai‘i at Mānoa, Honolulu, HI 96813, USAUniversity of Hawai‘i Cancer Center, University of Hawai‘i at Mānoa, Honolulu, HI 96813, USAHawai‘i Center for AIDS, John A. Burns School of Medicine, University of Hawai‘i at Mānoa, Honolulu, HI 96813, USADepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School Medicine, University of Hawai‘i at Mānoa, Honolulu, HI 96813, USADepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School Medicine, University of Hawai‘i at Mānoa, Honolulu, HI 96813, USADepartment of Medicine, John A. Burns School of Medicine, University of Hawai‘i at Mānoa, Honolulu, HI 96813, USAHawai‘i Center for AIDS, John A. Burns School of Medicine, University of Hawai‘i at Mānoa, Honolulu, HI 96813, USADepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School Medicine, University of Hawai‘i at Mānoa, Honolulu, HI 96813, USAPlatelets are anucleate cytoplasmic cell fragments that circulate in the blood, where they are involved in regulating hemostasis. Beyond their normal physiologic role, platelets have emerged as versatile effectors of immune response. During an infection, cell surface receptors enable platelets to recognize viruses, resulting in their activation. Activated platelets release biologically active molecules that further trigger host immune responses to protect the body against infection. Their impact on the immune response is also associated with the recruitment of circulating leukocytes to the site of infection. They can also aggregate with leukocytes, including lymphocytes, monocytes, and neutrophils, to immobilize pathogens and prevent viral dissemination. Despite their host protective role, platelets have also been shown to be associated with various pathophysiological processes. In this review, we will summarize platelet and HIV interactions during infection. We will also highlight and discuss platelet and platelet-derived mediators, how they interact with immune cells, and the multifaceted responsibilities of platelets in HIV infection. Furthermore, we will give an overview of non-AIDS comorbidities linked to platelet dysfunction and the impact of antiretroviral therapy on platelet function.https://www.mdpi.com/2218-273X/13/11/1608plateletsHIVviral persistenceinflammationcoagulationHIV complications |
| spellingShingle | Thomas Awamura Elizabeth S. Nakasone Louie Mar Gangcuangco Natalie T. Subia Aeron-Justin Bali Dominic C. Chow Cecilia M. Shikuma Juwon Park Platelet and HIV Interactions and Their Contribution to Non-AIDS Comorbidities Biomolecules platelets HIV viral persistence inflammation coagulation HIV complications |
| title | Platelet and HIV Interactions and Their Contribution to Non-AIDS Comorbidities |
| title_full | Platelet and HIV Interactions and Their Contribution to Non-AIDS Comorbidities |
| title_fullStr | Platelet and HIV Interactions and Their Contribution to Non-AIDS Comorbidities |
| title_full_unstemmed | Platelet and HIV Interactions and Their Contribution to Non-AIDS Comorbidities |
| title_short | Platelet and HIV Interactions and Their Contribution to Non-AIDS Comorbidities |
| title_sort | platelet and hiv interactions and their contribution to non aids comorbidities |
| topic | platelets HIV viral persistence inflammation coagulation HIV complications |
| url | https://www.mdpi.com/2218-273X/13/11/1608 |
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