The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat
Both ureteral obstruction (UO) and hypertension are common conditions that affect kidney functions. Hypertension and chronic kidney disease are closely associated with an overlapping and intermingled cause-and-effect relationship. The effect of hypertension on the renal dysfunction following reversi...
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7365 |
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| author | Fayez T. Hammad Loay Lubbad Suhail Al-Salam Javed Yasin Mohamed Fizur Nagoor Meeran Shreesh Ojha Waheed F. Hammad |
| author_facet | Fayez T. Hammad Loay Lubbad Suhail Al-Salam Javed Yasin Mohamed Fizur Nagoor Meeran Shreesh Ojha Waheed F. Hammad |
| author_sort | Fayez T. Hammad |
| collection | DOAJ |
| description | Both ureteral obstruction (UO) and hypertension are common conditions that affect kidney functions. Hypertension and chronic kidney disease are closely associated with an overlapping and intermingled cause-and-effect relationship. The effect of hypertension on the renal dysfunction following reversible UO has not been studied previously. To study this effect, spontaneously hypertensive (G-HT, <i>n</i> = 10) and normotensive Wistar (G-NT, <i>n</i> = 10) rats underwent 48-h reversible left unilateral UO (UUO), and the effect of UUO was studied 96 h following UUO reversal. The glomerular filtration rate, renal blood flow, and renal tubular functions such as the fractional excretion of sodium in the post-obstructed left kidney (POK) in both groups were significantly altered compared with the non-obstructed right kidney (NOK). However, the alterations in the G-HT were significantly more exaggerated when compared with the G-NT. Similar findings were observed with the histological features, gene expression of kidney injury markers, pro-inflammatory, pro-fibrotic and pro-apoptotic cytokines, and pro-collagen, as well as tissue levels of apoptotic markers. We conclude that hypertension has significantly exaggerated the alterations in renal functions and other parameters of renal injury associated with UUO. |
| first_indexed | 2024-03-11T04:56:34Z |
| format | Article |
| id | doaj.art-e4ce1afeb8d44293a15f08ae6c828928 |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:56:34Z |
| publishDate | 2023-04-01 |
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| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e4ce1afeb8d44293a15f08ae6c8289282023-11-17T19:39:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248736510.3390/ijms24087365The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the RatFayez T. Hammad0Loay Lubbad1Suhail Al-Salam2Javed Yasin3Mohamed Fizur Nagoor Meeran4Shreesh Ojha5Waheed F. Hammad6Department of Surgery, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab EmiratesDepartment of Surgery, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab EmiratesDepartment of Pathology, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab EmiratesDepartment of Internal Medicine, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab EmiratesDepartment of Pharmacology and Therapeutics, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab EmiratesDepartment of Pharmacology and Therapeutics, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab EmiratesSchool of Medicine, University of Jordan, Amman 11942, JordanBoth ureteral obstruction (UO) and hypertension are common conditions that affect kidney functions. Hypertension and chronic kidney disease are closely associated with an overlapping and intermingled cause-and-effect relationship. The effect of hypertension on the renal dysfunction following reversible UO has not been studied previously. To study this effect, spontaneously hypertensive (G-HT, <i>n</i> = 10) and normotensive Wistar (G-NT, <i>n</i> = 10) rats underwent 48-h reversible left unilateral UO (UUO), and the effect of UUO was studied 96 h following UUO reversal. The glomerular filtration rate, renal blood flow, and renal tubular functions such as the fractional excretion of sodium in the post-obstructed left kidney (POK) in both groups were significantly altered compared with the non-obstructed right kidney (NOK). However, the alterations in the G-HT were significantly more exaggerated when compared with the G-NT. Similar findings were observed with the histological features, gene expression of kidney injury markers, pro-inflammatory, pro-fibrotic and pro-apoptotic cytokines, and pro-collagen, as well as tissue levels of apoptotic markers. We conclude that hypertension has significantly exaggerated the alterations in renal functions and other parameters of renal injury associated with UUO.https://www.mdpi.com/1422-0067/24/8/7365hypertensionrenal functionsreversible unilateral ureteral obstruction |
| spellingShingle | Fayez T. Hammad Loay Lubbad Suhail Al-Salam Javed Yasin Mohamed Fizur Nagoor Meeran Shreesh Ojha Waheed F. Hammad The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat International Journal of Molecular Sciences hypertension renal functions reversible unilateral ureteral obstruction |
| title | The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat |
| title_full | The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat |
| title_fullStr | The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat |
| title_full_unstemmed | The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat |
| title_short | The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat |
| title_sort | effect of hypertension on the recovery of renal dysfunction following reversal of unilateral ureteral obstruction in the rat |
| topic | hypertension renal functions reversible unilateral ureteral obstruction |
| url | https://www.mdpi.com/1422-0067/24/8/7365 |
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