Abnormal Default Mode Network Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest
BackgroundGastrointestinal (GI) symptoms are prominent in many patients with major depressive disorder (MDD). However, it remains unclear whether MDD patients with GI symptoms have brain imaging alterations in the default mode network (DMN) regions.MethodsA total of 35 MDD patients with GI symptoms,...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.804621/full |
| _version_ | 1811330114082832384 |
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| author | Meiqi Yan Jindong Chen Feng Liu Huabing Li Jingping Zhao Wenbin Guo Wenbin Guo |
| author_facet | Meiqi Yan Jindong Chen Feng Liu Huabing Li Jingping Zhao Wenbin Guo Wenbin Guo |
| author_sort | Meiqi Yan |
| collection | DOAJ |
| description | BackgroundGastrointestinal (GI) symptoms are prominent in many patients with major depressive disorder (MDD). However, it remains unclear whether MDD patients with GI symptoms have brain imaging alterations in the default mode network (DMN) regions.MethodsA total of 35 MDD patients with GI symptoms, 17 MDD patients without GI symptoms, and 28 healthy controls (HCs) were recruited. All participants underwent resting-state functional magnetic resonance imaging scans. Network homogeneity (NH) and support vector machine (SVM) methods were used to analyze the imaging data.ResultsGastrointestinal group showed higher 17-item Hamilton Rating Scale for Depression total scores and factor scores than the non-GI group. Compared with the non-GI group and HCs, the GI group showed decreased NH in the right middle temporal gyrus (MTG) and increased NH in the right precuneus (PCu). The SVM results showed that a combination of NH values of the right PCu and the right MTG exhibited the highest accuracy of 88.46% (46/52) to discriminate MDD patients with GI symptoms from those without GI symptoms.ConclusionMajor depressive disorder patients with GI symptoms have more severe depressive symptoms than those without GI symptoms. Distinctive NH patterns in the DMN exist in MDD patients with GI symptoms, which can be applied as a potential brain imaging marker to discriminate MDD patients with GI symptoms from those without GI symptoms. |
| first_indexed | 2024-04-13T15:55:46Z |
| format | Article |
| id | doaj.art-e4ce43124b444881b7766598647e74df |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T15:55:46Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-e4ce43124b444881b7766598647e74df2022-12-22T02:40:43ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-03-011410.3389/fnagi.2022.804621804621Abnormal Default Mode Network Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at RestMeiqi Yan0Jindong Chen1Feng Liu2Huabing Li3Jingping Zhao4Wenbin Guo5Wenbin Guo6Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Radiology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Radiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Psychiatry, The Third People’s Hospital of Foshan, Foshan, ChinaBackgroundGastrointestinal (GI) symptoms are prominent in many patients with major depressive disorder (MDD). However, it remains unclear whether MDD patients with GI symptoms have brain imaging alterations in the default mode network (DMN) regions.MethodsA total of 35 MDD patients with GI symptoms, 17 MDD patients without GI symptoms, and 28 healthy controls (HCs) were recruited. All participants underwent resting-state functional magnetic resonance imaging scans. Network homogeneity (NH) and support vector machine (SVM) methods were used to analyze the imaging data.ResultsGastrointestinal group showed higher 17-item Hamilton Rating Scale for Depression total scores and factor scores than the non-GI group. Compared with the non-GI group and HCs, the GI group showed decreased NH in the right middle temporal gyrus (MTG) and increased NH in the right precuneus (PCu). The SVM results showed that a combination of NH values of the right PCu and the right MTG exhibited the highest accuracy of 88.46% (46/52) to discriminate MDD patients with GI symptoms from those without GI symptoms.ConclusionMajor depressive disorder patients with GI symptoms have more severe depressive symptoms than those without GI symptoms. Distinctive NH patterns in the DMN exist in MDD patients with GI symptoms, which can be applied as a potential brain imaging marker to discriminate MDD patients with GI symptoms from those without GI symptoms.https://www.frontiersin.org/articles/10.3389/fnagi.2022.804621/fullmajor depressive disorderdefault mode networknetwork homogeneitygastrointestinal symptomsmagnetic resonance imaging |
| spellingShingle | Meiqi Yan Jindong Chen Feng Liu Huabing Li Jingping Zhao Wenbin Guo Wenbin Guo Abnormal Default Mode Network Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest Frontiers in Aging Neuroscience major depressive disorder default mode network network homogeneity gastrointestinal symptoms magnetic resonance imaging |
| title | Abnormal Default Mode Network Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest |
| title_full | Abnormal Default Mode Network Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest |
| title_fullStr | Abnormal Default Mode Network Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest |
| title_full_unstemmed | Abnormal Default Mode Network Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest |
| title_short | Abnormal Default Mode Network Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest |
| title_sort | abnormal default mode network homogeneity in major depressive disorder with gastrointestinal symptoms at rest |
| topic | major depressive disorder default mode network network homogeneity gastrointestinal symptoms magnetic resonance imaging |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.804621/full |
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