Organ-Sparing Surgery for Testicular Germ Cell Tumors: A Current Perspective
<i>Background and Objectives:</i> We aimed to evaluate the oncological and functional outcomes of organ-sparing surgery for testicular germ cell tumors, a procedure that seeks to strike a balance between effective cancer control and organ preservation, in the treatment of testicular tumo...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/7/1249 |
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| author | Esther García Rojo Gianluca Giannarini Borja García Gómez Javier Amalio Feltes Ochoa Félix Guerrero Ramos Manuel Alonso Isa Ricardo Brime Menendez David Manuel Saenz Calzada Juan Justo Quintas Agustín Fraile Celeste Manfredi Javier Romero Otero |
| author_facet | Esther García Rojo Gianluca Giannarini Borja García Gómez Javier Amalio Feltes Ochoa Félix Guerrero Ramos Manuel Alonso Isa Ricardo Brime Menendez David Manuel Saenz Calzada Juan Justo Quintas Agustín Fraile Celeste Manfredi Javier Romero Otero |
| author_sort | Esther García Rojo |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> We aimed to evaluate the oncological and functional outcomes of organ-sparing surgery for testicular germ cell tumors, a procedure that seeks to strike a balance between effective cancer control and organ preservation, in the treatment of testicular tumors. We aimed to discuss the surgical technique and complications, and determine the appropriate candidate selection for this approach. <i>Material and Methods:</i> A comprehensive literature search was conducted to identify relevant studies on organ-sparing surgery for testicular tumors. Various databases, including PubMed, Embase, and Cochrane Library, were used. Studies reporting on surgical techniques, complications, and oncologic and functional outcomes were included for analysis. <i>Results:</i> Current evidence suggests that organ-sparing surgery for testicular germ cell tumors can be considered a safe and efficacious alternative to radical orchiectomy. The procedure is associated with adequate oncological control, as indicated by low recurrence rates and low complication rates. Endocrine testicular function can be preserved in around 80–90% of patients and paternity can be achieved in approximately half of the patients. Candidate selection for this surgery is typically based on the following criteria: pre-surgery normal levels of testosterone and luteinizing hormone, synchronous or metachronous bilateral tumors, tumor in a solitary testis, and tumor size less than 50% of the testis. <i>Conclusions:</i> Organ-sparing surgery for testicular germ cell tumors offers a promising approach that balances oncological control and preservation of testicular function. Further research, including large-scale prospective studies and long-term follow-ups, is warranted to validate the effectiveness and durability of organ-sparing surgery and to identify optimal patient selection criteria. |
| first_indexed | 2024-03-11T00:51:17Z |
| format | Article |
| id | doaj.art-e4ce73c4af7645578cd22d3e8ef12f2a |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T00:51:17Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-e4ce73c4af7645578cd22d3e8ef12f2a2023-11-18T20:23:59ZengMDPI AGMedicina1010-660X1648-91442023-07-01597124910.3390/medicina59071249Organ-Sparing Surgery for Testicular Germ Cell Tumors: A Current PerspectiveEsther García Rojo0Gianluca Giannarini1Borja García Gómez2Javier Amalio Feltes Ochoa3Félix Guerrero Ramos4Manuel Alonso Isa5Ricardo Brime Menendez6David Manuel Saenz Calzada7Juan Justo Quintas8Agustín Fraile9Celeste Manfredi10Javier Romero Otero11Department of Urology, Hospital Universitario HM Sanchinarro, 28050 Madrid, SpainUrology Unit, Santa Maria della Misericordia University Hospital, 33100 Udine, ItalyROC Clinic Direction, Martínez Campos 17, 28010 Madrid, SpainROC Clinic Direction, Martínez Campos 17, 28010 Madrid, SpainDepartment of Urology, Hospital Universitario HM Sanchinarro, 28050 Madrid, SpainROC Clinic Direction, Martínez Campos 17, 28010 Madrid, SpainDepartment of Urology, Hospital Universitario HM Sanchinarro, 28050 Madrid, SpainROC Clinic Direction, Martínez Campos 17, 28010 Madrid, SpainDepartment of Urology, Hospital Universitario HM Sanchinarro, 28050 Madrid, SpainROC Clinic Direction, Martínez Campos 17, 28010 Madrid, SpainUnit of Urology, Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 81100 Naples, ItalyDepartment of Urology, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain<i>Background and Objectives:</i> We aimed to evaluate the oncological and functional outcomes of organ-sparing surgery for testicular germ cell tumors, a procedure that seeks to strike a balance between effective cancer control and organ preservation, in the treatment of testicular tumors. We aimed to discuss the surgical technique and complications, and determine the appropriate candidate selection for this approach. <i>Material and Methods:</i> A comprehensive literature search was conducted to identify relevant studies on organ-sparing surgery for testicular tumors. Various databases, including PubMed, Embase, and Cochrane Library, were used. Studies reporting on surgical techniques, complications, and oncologic and functional outcomes were included for analysis. <i>Results:</i> Current evidence suggests that organ-sparing surgery for testicular germ cell tumors can be considered a safe and efficacious alternative to radical orchiectomy. The procedure is associated with adequate oncological control, as indicated by low recurrence rates and low complication rates. Endocrine testicular function can be preserved in around 80–90% of patients and paternity can be achieved in approximately half of the patients. Candidate selection for this surgery is typically based on the following criteria: pre-surgery normal levels of testosterone and luteinizing hormone, synchronous or metachronous bilateral tumors, tumor in a solitary testis, and tumor size less than 50% of the testis. <i>Conclusions:</i> Organ-sparing surgery for testicular germ cell tumors offers a promising approach that balances oncological control and preservation of testicular function. Further research, including large-scale prospective studies and long-term follow-ups, is warranted to validate the effectiveness and durability of organ-sparing surgery and to identify optimal patient selection criteria.https://www.mdpi.com/1648-9144/59/7/1249testicular cancertesticular tumorsorgan sparingsurgery |
| spellingShingle | Esther García Rojo Gianluca Giannarini Borja García Gómez Javier Amalio Feltes Ochoa Félix Guerrero Ramos Manuel Alonso Isa Ricardo Brime Menendez David Manuel Saenz Calzada Juan Justo Quintas Agustín Fraile Celeste Manfredi Javier Romero Otero Organ-Sparing Surgery for Testicular Germ Cell Tumors: A Current Perspective Medicina testicular cancer testicular tumors organ sparing surgery |
| title | Organ-Sparing Surgery for Testicular Germ Cell Tumors: A Current Perspective |
| title_full | Organ-Sparing Surgery for Testicular Germ Cell Tumors: A Current Perspective |
| title_fullStr | Organ-Sparing Surgery for Testicular Germ Cell Tumors: A Current Perspective |
| title_full_unstemmed | Organ-Sparing Surgery for Testicular Germ Cell Tumors: A Current Perspective |
| title_short | Organ-Sparing Surgery for Testicular Germ Cell Tumors: A Current Perspective |
| title_sort | organ sparing surgery for testicular germ cell tumors a current perspective |
| topic | testicular cancer testicular tumors organ sparing surgery |
| url | https://www.mdpi.com/1648-9144/59/7/1249 |
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