Comparative Effect of Three Different Exercise Intensities in Combination with Diazoxide on Contraction Capacity and Oxidative Stress of Skeletal Muscle in Obese Rats
Obesity is a chronic disease that impairs skeletal muscle function, affects the ability to contract, and promotes the development of fatigue. For this reason, the study of treatments that seek to reduce the harmful effects of obesity on muscle tissue has been deepened. Diazoxide treatment and variou...
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MDPI AG
2022-09-01
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| author | Mariana Gómez-Barroso Manuel A. Vargas-Vargas Donovan J. Peña-Montes Christian Cortés-Rojo Alfredo Saavedra-Molina Elizabeth Sánchez-Duarte Alain R. Rodríguez-Orozco Rocío Montoya-Pérez |
| author_facet | Mariana Gómez-Barroso Manuel A. Vargas-Vargas Donovan J. Peña-Montes Christian Cortés-Rojo Alfredo Saavedra-Molina Elizabeth Sánchez-Duarte Alain R. Rodríguez-Orozco Rocío Montoya-Pérez |
| author_sort | Mariana Gómez-Barroso |
| collection | DOAJ |
| description | Obesity is a chronic disease that impairs skeletal muscle function, affects the ability to contract, and promotes the development of fatigue. For this reason, the study of treatments that seek to reduce the harmful effects of obesity on muscle tissue has been deepened. Diazoxide treatment and various exercise protocols have been proposed to protect skeletal muscle against oxidative stress and its effects. However, the intensity and duration of exercise combined with diazoxide that would obtain the best results for improving skeletal muscle function in obese rats is unknown. To this end, this study evaluated the effects of three different exercise intensities combined with diazoxide on contraction capacity, resistance to fatigue, markers of oxidative stress, lipid peroxidation, ROS, and glutathione redox status of skeletal muscle. The results showed that treatments with diazoxide and exercise at different intensities improved muscle contraction capacity by reducing oxidative stress during obesity, with the best results being obtained with low-intensity exercise in combination with diazoxide. Therefore, these results suggest that diazoxide and low-intensity exercise improve muscle function during obesity by decreasing oxidative stress with the same efficiency as a moderate-intensity exercise protocol. |
| first_indexed | 2024-03-10T00:40:46Z |
| format | Article |
| id | doaj.art-e4cee8c35963486dabea673dc99bee5b |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T00:40:46Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-e4cee8c35963486dabea673dc99bee5b2023-11-23T15:08:19ZengMDPI AGBiology2079-77372022-09-01119136710.3390/biology11091367Comparative Effect of Three Different Exercise Intensities in Combination with Diazoxide on Contraction Capacity and Oxidative Stress of Skeletal Muscle in Obese RatsMariana Gómez-Barroso0Manuel A. Vargas-Vargas1Donovan J. Peña-Montes2Christian Cortés-Rojo3Alfredo Saavedra-Molina4Elizabeth Sánchez-Duarte5Alain R. Rodríguez-Orozco6Rocío Montoya-Pérez7Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Francisco J. Múgica S/N, Col. Felicitas del Río, Morelia 58030, MexicoInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Francisco J. Múgica S/N, Col. Felicitas del Río, Morelia 58030, MexicoInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Francisco J. Múgica S/N, Col. Felicitas del Río, Morelia 58030, MexicoInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Francisco J. Múgica S/N, Col. Felicitas del Río, Morelia 58030, MexicoInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Francisco J. Múgica S/N, Col. Felicitas del Río, Morelia 58030, MexicoDepartamento de Ciencias Aplicadas al Trabajo, Universidad de Guanajuato, Campus León, Eugenio Garza Sada 572, Lomas del Campestre Sección 2, León 37150, MexicoFacultad de Ciencias Médicas y Biológicas “Dr. Ignacio Chavez”, Universidad Michoacana de San Nicolás de Hidalgo Av. Dr. Rafael Carrillo S/N Esq. Dr. Salvador González Herrejon, Bosque Cuauhtémoc, Morelia 58020, MexicoInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Francisco J. Múgica S/N, Col. Felicitas del Río, Morelia 58030, MexicoObesity is a chronic disease that impairs skeletal muscle function, affects the ability to contract, and promotes the development of fatigue. For this reason, the study of treatments that seek to reduce the harmful effects of obesity on muscle tissue has been deepened. Diazoxide treatment and various exercise protocols have been proposed to protect skeletal muscle against oxidative stress and its effects. However, the intensity and duration of exercise combined with diazoxide that would obtain the best results for improving skeletal muscle function in obese rats is unknown. To this end, this study evaluated the effects of three different exercise intensities combined with diazoxide on contraction capacity, resistance to fatigue, markers of oxidative stress, lipid peroxidation, ROS, and glutathione redox status of skeletal muscle. The results showed that treatments with diazoxide and exercise at different intensities improved muscle contraction capacity by reducing oxidative stress during obesity, with the best results being obtained with low-intensity exercise in combination with diazoxide. Therefore, these results suggest that diazoxide and low-intensity exercise improve muscle function during obesity by decreasing oxidative stress with the same efficiency as a moderate-intensity exercise protocol.https://www.mdpi.com/2079-7737/11/9/1367skeletal muscleobesityfatigueoxidative stressexercisediazoxide |
| spellingShingle | Mariana Gómez-Barroso Manuel A. Vargas-Vargas Donovan J. Peña-Montes Christian Cortés-Rojo Alfredo Saavedra-Molina Elizabeth Sánchez-Duarte Alain R. Rodríguez-Orozco Rocío Montoya-Pérez Comparative Effect of Three Different Exercise Intensities in Combination with Diazoxide on Contraction Capacity and Oxidative Stress of Skeletal Muscle in Obese Rats Biology skeletal muscle obesity fatigue oxidative stress exercise diazoxide |
| title | Comparative Effect of Three Different Exercise Intensities in Combination with Diazoxide on Contraction Capacity and Oxidative Stress of Skeletal Muscle in Obese Rats |
| title_full | Comparative Effect of Three Different Exercise Intensities in Combination with Diazoxide on Contraction Capacity and Oxidative Stress of Skeletal Muscle in Obese Rats |
| title_fullStr | Comparative Effect of Three Different Exercise Intensities in Combination with Diazoxide on Contraction Capacity and Oxidative Stress of Skeletal Muscle in Obese Rats |
| title_full_unstemmed | Comparative Effect of Three Different Exercise Intensities in Combination with Diazoxide on Contraction Capacity and Oxidative Stress of Skeletal Muscle in Obese Rats |
| title_short | Comparative Effect of Three Different Exercise Intensities in Combination with Diazoxide on Contraction Capacity and Oxidative Stress of Skeletal Muscle in Obese Rats |
| title_sort | comparative effect of three different exercise intensities in combination with diazoxide on contraction capacity and oxidative stress of skeletal muscle in obese rats |
| topic | skeletal muscle obesity fatigue oxidative stress exercise diazoxide |
| url | https://www.mdpi.com/2079-7737/11/9/1367 |
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