Biocompatible Hydrogel for Intra-Articular Implantation Comprising Cationic and Anionic Polymers of Natural Origin: In Vivo Evaluation in a Rabbit Model
We describe the functional capability of a cross-linked hydrogel composed of sulfated glycosaminoglycans and a cationic cellulose by conducting trials on experimental animal models using intra-articular implants to treat an articular disease called osteoarthritis. Forty-eight mature New Zealand whit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/24/4426 |
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| author | Karina L. Bierbrauer Roxana V. Alasino Fernando E. Barclay Eduardo M. Belotti Hugo H. Ortega Dante M. Beltramo |
| author_facet | Karina L. Bierbrauer Roxana V. Alasino Fernando E. Barclay Eduardo M. Belotti Hugo H. Ortega Dante M. Beltramo |
| author_sort | Karina L. Bierbrauer |
| collection | DOAJ |
| description | We describe the functional capability of a cross-linked hydrogel composed of sulfated glycosaminoglycans and a cationic cellulose by conducting trials on experimental animal models using intra-articular implants to treat an articular disease called osteoarthritis. Forty-eight mature New Zealand white rabbits were divided into three experimental groups: A, B, and C. Group A and B underwent unilateral anterior cruciate ligament transection (ACLT) of the right knee. Subsequently, both knees of group A were treated with the injectable formulation under study. Meanwhile, group B was treated with sterile PBS (placebo). The animals of group C were surgically operated in both knees: Commercial hyaluronic acid (HA) was implanted in the left knee, and the formulation under study was implanted in the right knee. After implantation, all specimens underwent several evaluations at 3, 6, and 12 months postoperatively. At 6 months, no significant differences were detected between the right and left knees of the different groups. However, significant differences were observed between both knees at 12 months in group C, with less cartilage damage in the right knees implanted with our hydrogel. Therefore, in vivo studies have demonstrated hydrogel safety, superior permanence, and less cartilage damage for long-term follow up 12 months after implantation for the formulation under study compared with commercial HA. |
| first_indexed | 2024-03-10T03:15:03Z |
| format | Article |
| id | doaj.art-e4cf1eac12b64e2f9ee4b2c83de3ea84 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T03:15:03Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-e4cf1eac12b64e2f9ee4b2c83de3ea842023-11-23T10:16:12ZengMDPI AGPolymers2073-43602021-12-011324442610.3390/polym13244426Biocompatible Hydrogel for Intra-Articular Implantation Comprising Cationic and Anionic Polymers of Natural Origin: In Vivo Evaluation in a Rabbit ModelKarina L. Bierbrauer0Roxana V. Alasino1Fernando E. Barclay2Eduardo M. Belotti3Hugo H. Ortega4Dante M. Beltramo5Centro de Excelencia en Productos y Procesos de Córdoba, Gobierno de la Provincia de Córdoba, Pabellón CEPROCOR, Santa Maria de Punilla, Córdoba CP 5164, ArgentinaCentro de Excelencia en Productos y Procesos de Córdoba, Gobierno de la Provincia de Córdoba, Pabellón CEPROCOR, Santa Maria de Punilla, Córdoba CP 5164, ArgentinaInstituto Argentino de Diagnóstico y Tratamiento SA (IADT) en Ortopedia y Traumatología, Cirugía Artroscópica y Medicina del Deporte, Marcelo T. de Alvear 2346/2400, Buenos Aires C1122AAL, ArgentinaConsejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Godoy Cruz 2290, Buenos Aires C1425FQB, ArgentinaConsejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Godoy Cruz 2290, Buenos Aires C1425FQB, ArgentinaCentro de Excelencia en Productos y Procesos de Córdoba, Gobierno de la Provincia de Córdoba, Pabellón CEPROCOR, Santa Maria de Punilla, Córdoba CP 5164, ArgentinaWe describe the functional capability of a cross-linked hydrogel composed of sulfated glycosaminoglycans and a cationic cellulose by conducting trials on experimental animal models using intra-articular implants to treat an articular disease called osteoarthritis. Forty-eight mature New Zealand white rabbits were divided into three experimental groups: A, B, and C. Group A and B underwent unilateral anterior cruciate ligament transection (ACLT) of the right knee. Subsequently, both knees of group A were treated with the injectable formulation under study. Meanwhile, group B was treated with sterile PBS (placebo). The animals of group C were surgically operated in both knees: Commercial hyaluronic acid (HA) was implanted in the left knee, and the formulation under study was implanted in the right knee. After implantation, all specimens underwent several evaluations at 3, 6, and 12 months postoperatively. At 6 months, no significant differences were detected between the right and left knees of the different groups. However, significant differences were observed between both knees at 12 months in group C, with less cartilage damage in the right knees implanted with our hydrogel. Therefore, in vivo studies have demonstrated hydrogel safety, superior permanence, and less cartilage damage for long-term follow up 12 months after implantation for the formulation under study compared with commercial HA.https://www.mdpi.com/2073-4360/13/24/4426polyquaternium-10chondroitin sulfatehydrogelosteoarthritisintra-articular implantrabbit model |
| spellingShingle | Karina L. Bierbrauer Roxana V. Alasino Fernando E. Barclay Eduardo M. Belotti Hugo H. Ortega Dante M. Beltramo Biocompatible Hydrogel for Intra-Articular Implantation Comprising Cationic and Anionic Polymers of Natural Origin: In Vivo Evaluation in a Rabbit Model Polymers polyquaternium-10 chondroitin sulfate hydrogel osteoarthritis intra-articular implant rabbit model |
| title | Biocompatible Hydrogel for Intra-Articular Implantation Comprising Cationic and Anionic Polymers of Natural Origin: In Vivo Evaluation in a Rabbit Model |
| title_full | Biocompatible Hydrogel for Intra-Articular Implantation Comprising Cationic and Anionic Polymers of Natural Origin: In Vivo Evaluation in a Rabbit Model |
| title_fullStr | Biocompatible Hydrogel for Intra-Articular Implantation Comprising Cationic and Anionic Polymers of Natural Origin: In Vivo Evaluation in a Rabbit Model |
| title_full_unstemmed | Biocompatible Hydrogel for Intra-Articular Implantation Comprising Cationic and Anionic Polymers of Natural Origin: In Vivo Evaluation in a Rabbit Model |
| title_short | Biocompatible Hydrogel for Intra-Articular Implantation Comprising Cationic and Anionic Polymers of Natural Origin: In Vivo Evaluation in a Rabbit Model |
| title_sort | biocompatible hydrogel for intra articular implantation comprising cationic and anionic polymers of natural origin in vivo evaluation in a rabbit model |
| topic | polyquaternium-10 chondroitin sulfate hydrogel osteoarthritis intra-articular implant rabbit model |
| url | https://www.mdpi.com/2073-4360/13/24/4426 |
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