Orientation dependence of R2 relaxation in the newborn brain
In MRI the transverse relaxation rate, R2 = 1/T2, shows dependence on the orientation of ordered tissue relative to the main magnetic field. In previous studies, orientation effects of R2 relaxation in the mature brain's white matter have been found to be described by a susceptibility-based mod...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922008230 |
| _version_ | 1811201360952033280 |
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| author | Lara M. Bartels Jonathan Doucette Christoph Birkl Yuting Zhang Alexander M. Weber Alexander Rauscher |
| author_facet | Lara M. Bartels Jonathan Doucette Christoph Birkl Yuting Zhang Alexander M. Weber Alexander Rauscher |
| author_sort | Lara M. Bartels |
| collection | DOAJ |
| description | In MRI the transverse relaxation rate, R2 = 1/T2, shows dependence on the orientation of ordered tissue relative to the main magnetic field. In previous studies, orientation effects of R2 relaxation in the mature brain's white matter have been found to be described by a susceptibility-based model of diffusion through local magnetic field inhomogeneities created by the diamagnetic myelin sheaths. Orientation effects in human newborn white matter have not yet been investigated. The newborn brain is known to contain very little myelin and is therefore expected to exhibit a decrease in orientation dependence driven by susceptibility-based effects. We measured R2 orientation dependence in the white matter of human newborns. R2 data were acquired with a 3D Gradient and Spin Echo (GRASE) sequence and fiber orientation was mapped with diffusion tensor imaging (DTI). We found orientation dependence in newborn white matter that is not consistent with the susceptibility-based model and is best described by a model of residual dipolar coupling. In the near absence of myelin in the newborn brain, these findings suggest the presence of residual dipolar coupling between rotationally restricted water molecules. This has important implications for quantitative imaging methods such as myelin water imaging, and suggests orientation dependence of R2 as a potential marker in early brain development. |
| first_indexed | 2024-04-12T02:20:35Z |
| format | Article |
| id | doaj.art-e4cf57fd9c6946808e37913922b49a45 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-12T02:20:35Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-e4cf57fd9c6946808e37913922b49a452022-12-22T03:52:08ZengElsevierNeuroImage1095-95722022-12-01264119702Orientation dependence of R2 relaxation in the newborn brainLara M. Bartels0Jonathan Doucette1Christoph Birkl2Yuting Zhang3Alexander M. Weber4Alexander Rauscher5Department of Physics and Astronomy, University of British Columbia, Vancouver V6T 1Z1, Canada; UBC MRI Research Centre, University of British Columbia, Vancouver V6T 2B5, Canada; Division of Neurology, Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada; Corresponding author at: Department of Physics and Astronomy, University of British Columbia, Vancouver, Canada.Department of Physics and Astronomy, University of British Columbia, Vancouver V6T 1Z1, Canada; UBC MRI Research Centre, University of British Columbia, Vancouver V6T 2B5, Canada; Division of Neurology, Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, CanadaUBC MRI Research Centre, University of British Columbia, Vancouver V6T 2B5, Canada; Department of Neuroradiology, Medical University of Innsbruck, Innsbruck 6020, AustriaDepartment of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China; Key Laboratory of Pediatrics, Chongqing Medical University, Chongqing, China; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, ChinaUBC MRI Research Centre, University of British Columbia, Vancouver V6T 2B5, Canada; Division of Neurology, Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, CanadaDepartment of Physics and Astronomy, University of British Columbia, Vancouver V6T 1Z1, Canada; UBC MRI Research Centre, University of British Columbia, Vancouver V6T 2B5, Canada; Division of Neurology, Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver V6T 1Z3, CanadaIn MRI the transverse relaxation rate, R2 = 1/T2, shows dependence on the orientation of ordered tissue relative to the main magnetic field. In previous studies, orientation effects of R2 relaxation in the mature brain's white matter have been found to be described by a susceptibility-based model of diffusion through local magnetic field inhomogeneities created by the diamagnetic myelin sheaths. Orientation effects in human newborn white matter have not yet been investigated. The newborn brain is known to contain very little myelin and is therefore expected to exhibit a decrease in orientation dependence driven by susceptibility-based effects. We measured R2 orientation dependence in the white matter of human newborns. R2 data were acquired with a 3D Gradient and Spin Echo (GRASE) sequence and fiber orientation was mapped with diffusion tensor imaging (DTI). We found orientation dependence in newborn white matter that is not consistent with the susceptibility-based model and is best described by a model of residual dipolar coupling. In the near absence of myelin in the newborn brain, these findings suggest the presence of residual dipolar coupling between rotationally restricted water molecules. This has important implications for quantitative imaging methods such as myelin water imaging, and suggests orientation dependence of R2 as a potential marker in early brain development.http://www.sciencedirect.com/science/article/pii/S1053811922008230T2 anisotropyFiber orientationNeonatesWhite matter microstructureDipole- dipole interaction |
| spellingShingle | Lara M. Bartels Jonathan Doucette Christoph Birkl Yuting Zhang Alexander M. Weber Alexander Rauscher Orientation dependence of R2 relaxation in the newborn brain NeuroImage T2 anisotropy Fiber orientation Neonates White matter microstructure Dipole- dipole interaction |
| title | Orientation dependence of R2 relaxation in the newborn brain |
| title_full | Orientation dependence of R2 relaxation in the newborn brain |
| title_fullStr | Orientation dependence of R2 relaxation in the newborn brain |
| title_full_unstemmed | Orientation dependence of R2 relaxation in the newborn brain |
| title_short | Orientation dependence of R2 relaxation in the newborn brain |
| title_sort | orientation dependence of r2 relaxation in the newborn brain |
| topic | T2 anisotropy Fiber orientation Neonates White matter microstructure Dipole- dipole interaction |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922008230 |
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