The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome
ABSTRACT Tuberculosis remains a major health threat in much of the world. New vaccines against Mycobacterium tuberculosis are essential for preventing infection, disease, and transmission. However, the host immune responses that need to be induced by an effective vaccine remain unclear. Increasingly...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2016-05-01
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| Series: | mBio |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.00342-16 |
| _version_ | 1818838956965363712 |
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| author | Anthony M. Cadena JoAnne L. Flynn Sarah M. Fortune |
| author_facet | Anthony M. Cadena JoAnne L. Flynn Sarah M. Fortune |
| author_sort | Anthony M. Cadena |
| collection | DOAJ |
| description | ABSTRACT Tuberculosis remains a major health threat in much of the world. New vaccines against Mycobacterium tuberculosis are essential for preventing infection, disease, and transmission. However, the host immune responses that need to be induced by an effective vaccine remain unclear. Increasingly, it has become clear that early events in infection are of major importance in the eventual outcome of the infection. Studying such events in humans is challenging, as they occur within the lung and thoracic lymph nodes, and any clinical signs of early infection are relatively nonspecific. Nonetheless, clinical studies and animal models of tuberculosis have provided new insights into the local events that occur in the first few weeks of tuberculosis. Development of an effective vaccine requires a clear understanding of the successful (and detrimental) early host responses against M. tuberculosis, with the goal to improve upon natural immune responses and prevent infection or disease. |
| first_indexed | 2024-12-19T03:46:38Z |
| format | Article |
| id | doaj.art-e4d1058607c84486bcd304fd20fbf37e |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-19T03:46:38Z |
| publishDate | 2016-05-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-e4d1058607c84486bcd304fd20fbf37e2022-12-21T20:37:06ZengAmerican Society for MicrobiologymBio2150-75112016-05-017210.1128/mBio.00342-16The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence OutcomeAnthony M. Cadena0JoAnne L. Flynn1Sarah M. Fortune2Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USADepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USADepartment of Immunology and Infectious Disease, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USAABSTRACT Tuberculosis remains a major health threat in much of the world. New vaccines against Mycobacterium tuberculosis are essential for preventing infection, disease, and transmission. However, the host immune responses that need to be induced by an effective vaccine remain unclear. Increasingly, it has become clear that early events in infection are of major importance in the eventual outcome of the infection. Studying such events in humans is challenging, as they occur within the lung and thoracic lymph nodes, and any clinical signs of early infection are relatively nonspecific. Nonetheless, clinical studies and animal models of tuberculosis have provided new insights into the local events that occur in the first few weeks of tuberculosis. Development of an effective vaccine requires a clear understanding of the successful (and detrimental) early host responses against M. tuberculosis, with the goal to improve upon natural immune responses and prevent infection or disease.https://journals.asm.org/doi/10.1128/mBio.00342-16 |
| spellingShingle | Anthony M. Cadena JoAnne L. Flynn Sarah M. Fortune The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome mBio |
| title | The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome |
| title_full | The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome |
| title_fullStr | The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome |
| title_full_unstemmed | The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome |
| title_short | The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome |
| title_sort | importance of first impressions early events in named content content type genus species mycobacterium tuberculosis named content infection influence outcome |
| url | https://journals.asm.org/doi/10.1128/mBio.00342-16 |
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