Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs
Neurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determine...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1284306/full |
| _version_ | 1797660954023952384 |
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| author | Taesik Yun Yeon Chae Yoonhoi Koo Dohee Lee Hakhyun Kim Mhan-Pyo Yang Byeong-Teck Kang |
| author_facet | Taesik Yun Yeon Chae Yoonhoi Koo Dohee Lee Hakhyun Kim Mhan-Pyo Yang Byeong-Teck Kang |
| author_sort | Taesik Yun |
| collection | DOAJ |
| description | Neurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determined using a single-molecule array. Serum NfL concentrations were significantly higher in hypoxemic dogs without neurological signs (n = 6, 175.5 pg/mL) than in healthy dogs (n = 15, 15.9 pg/mL; p < 0.0001). Therefore, neuronal injury should be considered in dogs with hypoxemia caused by cardiopulmonary diseases, even in the absence of neurological signs. |
| first_indexed | 2024-03-11T18:38:18Z |
| format | Article |
| id | doaj.art-e4d19d059a44469ab1acd38e8ac501bc |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-11T18:38:18Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-e4d19d059a44469ab1acd38e8ac501bc2023-10-12T16:30:30ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-10-011010.3389/fvets.2023.12843061284306Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogsTaesik Yun0Yeon Chae1Yoonhoi Koo2Dohee Lee3Hakhyun Kim4Mhan-Pyo Yang5Byeong-Teck Kang6Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaCollege of Veterinary Medicine, Kyungpook National University, Daegu, Republic of KoreaLaboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaNeurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determined using a single-molecule array. Serum NfL concentrations were significantly higher in hypoxemic dogs without neurological signs (n = 6, 175.5 pg/mL) than in healthy dogs (n = 15, 15.9 pg/mL; p < 0.0001). Therefore, neuronal injury should be considered in dogs with hypoxemia caused by cardiopulmonary diseases, even in the absence of neurological signs.https://www.frontiersin.org/articles/10.3389/fvets.2023.1284306/fullbiomarkercaninehypoxemiaischemiaNfL |
| spellingShingle | Taesik Yun Yeon Chae Yoonhoi Koo Dohee Lee Hakhyun Kim Mhan-Pyo Yang Byeong-Teck Kang Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs Frontiers in Veterinary Science biomarker canine hypoxemia ischemia NfL |
| title | Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs |
| title_full | Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs |
| title_fullStr | Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs |
| title_full_unstemmed | Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs |
| title_short | Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs |
| title_sort | preliminary study of neurofilament light chain as a biomarker for hypoxia induced neuronal injury in dogs |
| topic | biomarker canine hypoxemia ischemia NfL |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1284306/full |
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