Impact of an intervention in the use of sequential antibiotic therapy in a Brazilian university hospital
INTRODUCTION: Sequential antibiotic therapy (SAT) is safe and economical. However, the unnecessary use of intravenous (IV) administration usually occurs. The objective of this work was to get to know the effectiveness of an intervention to implement the SAT in a teaching hospital in Brazil....
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2013-01-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000100050&lng=en&tlng=en |
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| author | Raquel Melo Rodrigues Astrídia Marília de Souza Fontes Orlando César Mantese Renata Souza Martins Miguel Tanús Jorge |
| author_facet | Raquel Melo Rodrigues Astrídia Marília de Souza Fontes Orlando César Mantese Renata Souza Martins Miguel Tanús Jorge |
| author_sort | Raquel Melo Rodrigues |
| collection | DOAJ |
| description | INTRODUCTION: Sequential antibiotic therapy (SAT) is safe and economical. However, the unnecessary use of intravenous (IV) administration usually occurs. The objective of this work was to get to know the effectiveness of an intervention to implement the SAT in a teaching hospital in Brazil. METHODS: This was a prospective and interventional study, historically controlled, and was conducted in the Hospital de Clínicas, Universidade Federal de Uberlândia, State of Minas Gerais, Brazil, a high complexity teaching hospital having 503 beds. In each of the periods, from 04/04/05 to 07/20/05 (pre-intervention) and from 09/24/07 to 12/20/07 (intervention), 117 patients were evaluated. After the pre-intervention period, guidelines were developed which were implemented during the intervention period along with educational measures and a reminder system added to the patients' prescription. RESULTS: In the pre-intervention and intervention periods, the IV antibiotics were used as treatment for a average time of 14.8 and 11.8 days, respectively. Ceftriaxone was the antibiotic most prescribed in both periods (23.4% and 21.6% respectively). Starting from the first prescription of antibiotics, the average length of hospitalization time was 21.8 and 17.5 days, respectively. The SAT occurred only in 4 and 5 courses of treatment, respectively, and 12.8% and 18.8% of the patients died in the respective periods. CONCLUSIONS: Under the presented conditions, the evaluated intervention strategy is ineffective in promoting the exchange of the antibiotic administration from IV to oral treatment (SAT). |
| first_indexed | 2024-04-13T22:24:14Z |
| format | Article |
| id | doaj.art-e4d1febb39f544a39560048ae17f6498 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T22:24:14Z |
| publishDate | 2013-01-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-e4d1febb39f544a39560048ae17f64982022-12-22T02:27:07ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492013-01-01461505410.1590/0037-868217382013S0037-86822013000100050Impact of an intervention in the use of sequential antibiotic therapy in a Brazilian university hospitalRaquel Melo RodriguesAstrídia Marília de Souza FontesOrlando César ManteseRenata Souza MartinsMiguel Tanús JorgeINTRODUCTION: Sequential antibiotic therapy (SAT) is safe and economical. However, the unnecessary use of intravenous (IV) administration usually occurs. The objective of this work was to get to know the effectiveness of an intervention to implement the SAT in a teaching hospital in Brazil. METHODS: This was a prospective and interventional study, historically controlled, and was conducted in the Hospital de Clínicas, Universidade Federal de Uberlândia, State of Minas Gerais, Brazil, a high complexity teaching hospital having 503 beds. In each of the periods, from 04/04/05 to 07/20/05 (pre-intervention) and from 09/24/07 to 12/20/07 (intervention), 117 patients were evaluated. After the pre-intervention period, guidelines were developed which were implemented during the intervention period along with educational measures and a reminder system added to the patients' prescription. RESULTS: In the pre-intervention and intervention periods, the IV antibiotics were used as treatment for a average time of 14.8 and 11.8 days, respectively. Ceftriaxone was the antibiotic most prescribed in both periods (23.4% and 21.6% respectively). Starting from the first prescription of antibiotics, the average length of hospitalization time was 21.8 and 17.5 days, respectively. The SAT occurred only in 4 and 5 courses of treatment, respectively, and 12.8% and 18.8% of the patients died in the respective periods. CONCLUSIONS: Under the presented conditions, the evaluated intervention strategy is ineffective in promoting the exchange of the antibiotic administration from IV to oral treatment (SAT).http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000100050&lng=en&tlng=enAntibioticsAntimicrobialAntibiotic policySwitch therapy |
| spellingShingle | Raquel Melo Rodrigues Astrídia Marília de Souza Fontes Orlando César Mantese Renata Souza Martins Miguel Tanús Jorge Impact of an intervention in the use of sequential antibiotic therapy in a Brazilian university hospital Revista da Sociedade Brasileira de Medicina Tropical Antibiotics Antimicrobial Antibiotic policy Switch therapy |
| title | Impact of an intervention in the use of sequential antibiotic therapy in a Brazilian university hospital |
| title_full | Impact of an intervention in the use of sequential antibiotic therapy in a Brazilian university hospital |
| title_fullStr | Impact of an intervention in the use of sequential antibiotic therapy in a Brazilian university hospital |
| title_full_unstemmed | Impact of an intervention in the use of sequential antibiotic therapy in a Brazilian university hospital |
| title_short | Impact of an intervention in the use of sequential antibiotic therapy in a Brazilian university hospital |
| title_sort | impact of an intervention in the use of sequential antibiotic therapy in a brazilian university hospital |
| topic | Antibiotics Antimicrobial Antibiotic policy Switch therapy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000100050&lng=en&tlng=en |
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