A Drug–Drug Multicomponent Crystal of Metformin and Dobesilate: Crystal Structure Analysis and Hygroscopicity Property
A drug–drug multicomponent crystal consisting of metformin (MET) and dobesilate (DBS) was prospectively connected by solvent cooling and evaporating co-crystallization using the multicomponent crystal strategy, not only to optimize the physicochemical properties of single drugs, but also to play a r...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/11/3472 |
| _version_ | 1797492526306820096 |
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| author | Lan Jiang Xiangnan Hu Linhong Cai |
| author_facet | Lan Jiang Xiangnan Hu Linhong Cai |
| author_sort | Lan Jiang |
| collection | DOAJ |
| description | A drug–drug multicomponent crystal consisting of metformin (MET) and dobesilate (DBS) was prospectively connected by solvent cooling and evaporating co-crystallization using the multicomponent crystal strategy, not only to optimize the physicochemical properties of single drugs, but also to play a role in the cooperative effect of DBS with the potential vascular protective effects of MET against diabetic retinopathy (DR). The crystal structure analysis demonstrated that MET and DBS were coupled in a 3D supramolecular structure connected by hydrogen-bonding interactions with a molar ratio of 1:1. Almost all hydrogen bond donors and receptors of MET and DBS participated in the bonding, which hindered the combination of remaining potential hydrogen bond sites and water molecules, resulting in a lower hygroscopicity property than MET alone. |
| first_indexed | 2024-03-10T01:04:57Z |
| format | Article |
| id | doaj.art-e4d552d723d54715b3c06a9346a37727 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T01:04:57Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e4d552d723d54715b3c06a9346a377272023-11-23T14:29:16ZengMDPI AGMolecules1420-30492022-05-012711347210.3390/molecules27113472A Drug–Drug Multicomponent Crystal of Metformin and Dobesilate: Crystal Structure Analysis and Hygroscopicity PropertyLan Jiang0Xiangnan Hu1Linhong Cai2College of Environment and Resources, Chongqing Technology and Business University, Chongqing 400067, ChinaDepartment of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing 400016, ChinaA drug–drug multicomponent crystal consisting of metformin (MET) and dobesilate (DBS) was prospectively connected by solvent cooling and evaporating co-crystallization using the multicomponent crystal strategy, not only to optimize the physicochemical properties of single drugs, but also to play a role in the cooperative effect of DBS with the potential vascular protective effects of MET against diabetic retinopathy (DR). The crystal structure analysis demonstrated that MET and DBS were coupled in a 3D supramolecular structure connected by hydrogen-bonding interactions with a molar ratio of 1:1. Almost all hydrogen bond donors and receptors of MET and DBS participated in the bonding, which hindered the combination of remaining potential hydrogen bond sites and water molecules, resulting in a lower hygroscopicity property than MET alone.https://www.mdpi.com/1420-3049/27/11/3472drug–drug multicomponent crystalmetformindobesilatediabetic retinopathyhydrogen-bonding interactionshygroscopicity property |
| spellingShingle | Lan Jiang Xiangnan Hu Linhong Cai A Drug–Drug Multicomponent Crystal of Metformin and Dobesilate: Crystal Structure Analysis and Hygroscopicity Property Molecules drug–drug multicomponent crystal metformin dobesilate diabetic retinopathy hydrogen-bonding interactions hygroscopicity property |
| title | A Drug–Drug Multicomponent Crystal of Metformin and Dobesilate: Crystal Structure Analysis and Hygroscopicity Property |
| title_full | A Drug–Drug Multicomponent Crystal of Metformin and Dobesilate: Crystal Structure Analysis and Hygroscopicity Property |
| title_fullStr | A Drug–Drug Multicomponent Crystal of Metformin and Dobesilate: Crystal Structure Analysis and Hygroscopicity Property |
| title_full_unstemmed | A Drug–Drug Multicomponent Crystal of Metformin and Dobesilate: Crystal Structure Analysis and Hygroscopicity Property |
| title_short | A Drug–Drug Multicomponent Crystal of Metformin and Dobesilate: Crystal Structure Analysis and Hygroscopicity Property |
| title_sort | drug drug multicomponent crystal of metformin and dobesilate crystal structure analysis and hygroscopicity property |
| topic | drug–drug multicomponent crystal metformin dobesilate diabetic retinopathy hydrogen-bonding interactions hygroscopicity property |
| url | https://www.mdpi.com/1420-3049/27/11/3472 |
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