Assessing the Capabilities of Transcranial Magnetic Stimulation (TMS) to Aid in the Removal of Brain Tumors Affecting the Motor Cortex: A Systematic Review
Lucas Jose Vaz Schiavao,1,2 Iuri Neville Ribeiro,1,2 Cintya Yukie Hayashi,1 Eberval Gadelha Figueiredo,1 Andre Russowsky Brunoni,1 Manoel Jacobsen Teixeira,1 Gabriel Pokorny,3 Wellingson Silva Paiva1 1Neurology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo- FMUSP – Uni...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-06-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/assessing-the-capabilities-of-transcranial-magnetic-stimulation-tms-to-peer-reviewed-fulltext-article-NDT |
| _version_ | 1818253316185915392 |
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| author | Schiavao LJV Neville Ribeiro I Yukie Hayashi C Gadelha Figueiredo E Russowsky Brunoni A Jacobsen Teixeira M Pokorny G Silva Paiva W |
| author_facet | Schiavao LJV Neville Ribeiro I Yukie Hayashi C Gadelha Figueiredo E Russowsky Brunoni A Jacobsen Teixeira M Pokorny G Silva Paiva W |
| author_sort | Schiavao LJV |
| collection | DOAJ |
| description | Lucas Jose Vaz Schiavao,1,2 Iuri Neville Ribeiro,1,2 Cintya Yukie Hayashi,1 Eberval Gadelha Figueiredo,1 Andre Russowsky Brunoni,1 Manoel Jacobsen Teixeira,1 Gabriel Pokorny,3 Wellingson Silva Paiva1 1Neurology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo- FMUSP – University of São Paulo, São Paulo, Brazil; 2Neurology, Instituto do Câncer do Estado de São Paulo – ICESP, São Paulo, Brazil; 3Spine, Instituto de Patologia da Coluna, São Paulo, BrazilCorrespondence: Gabriel Pokorny, Tel/Fax +55 11971652026, Email ghpokorny@gmail.comIntroduction: The brain tumor is frequently related to severe motor impairment and impacts the quality of life. The corticospinal tract can sometimes be affected depending on the type and size of the neoplasm, so different tools can evaluate motor function and connections. It is essential to organize surgical procedures and plan the approach. Functional motor status is mapped before, during, and after surgery. Studying corticospinal tract status can help map the functional areas, predict postoperative outcomes, and help the decision, reducing neurological deficits, aiming to preserve functional networks, using the concepts of white matters localization and fibbers connections. Nowadays, there are new techniques that provide functional information regarding the motor cortex, such as transcranial magnetic stimulation (TMS), direct cortical stimulation (DCS), and navigated TMS (nTMS). These tools can be used to plan a customized surgical strategy and the role of motor evoked potentials (MEPs) is well described during intra-operative, using intraoperative neuromonitoring. MEPs can help to localize primary motor areas and delineate the cut-off point of resection in real-time, using direct stimulation. In the post-operative, the MEP has increased your function as a predictive marker of permanent or transitory neurological lesion marker.Methods: Systematic review performed in MEDLINE via PUBMED, EMBASE, and SCOPUS databases regarding the post-operative assessment of MEP in patients with brain tumors. The search strategy included the following terms: ((“Evoked Potentials, Motor”[Mesh]) AND “Neoplasms”[Mesh]) AND “Transcranial Magnetic Stimulation”[Mesh] AND “Brain Tumor”[Mesh]), the analysis followed the PRISMA guidelines for systematic reviews, the review spanned until 06/04/2021, inclusion criteria were studies presenting confirmed diagnosis of brain tumor (primary or metastatic), patients > 18 y/o, using TMS, Navigated TMS, and/or Evoked Potentials as tools in preoperative planning or at the intra-operative helping the evaluation of the neurological status of the motor cortex, articles published in peer-reviewed journals, and written in English or Portuguese.Results: A total of 38 studies were selected for this review, of which 14 investigated the potential of nTMS to predict the occurrence of motor deficits, while 25 of the articles investigated the capabilities of the nTMS technique in performing pre/intraoperative neuro mapping of the motor cortex.Conclusion: Further studies regarding motor function assessment are needed and standardized protocols for MEPs also need to be defined.Keywords: brain tumors, transcranial magnetic resonance, systematic review, neurophysiology, motor cortex mapping |
| first_indexed | 2024-12-12T16:38:08Z |
| format | Article |
| id | doaj.art-e4d7d161fd0949c3a6eae71f35c88f2f |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-12-12T16:38:08Z |
| publishDate | 2022-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-e4d7d161fd0949c3a6eae71f35c88f2f2022-12-22T00:18:37ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212022-06-01Volume 181219123575995Assessing the Capabilities of Transcranial Magnetic Stimulation (TMS) to Aid in the Removal of Brain Tumors Affecting the Motor Cortex: A Systematic ReviewSchiavao LJVNeville Ribeiro IYukie Hayashi CGadelha Figueiredo ERussowsky Brunoni AJacobsen Teixeira MPokorny GSilva Paiva WLucas Jose Vaz Schiavao,1,2 Iuri Neville Ribeiro,1,2 Cintya Yukie Hayashi,1 Eberval Gadelha Figueiredo,1 Andre Russowsky Brunoni,1 Manoel Jacobsen Teixeira,1 Gabriel Pokorny,3 Wellingson Silva Paiva1 1Neurology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo- FMUSP – University of São Paulo, São Paulo, Brazil; 2Neurology, Instituto do Câncer do Estado de São Paulo – ICESP, São Paulo, Brazil; 3Spine, Instituto de Patologia da Coluna, São Paulo, BrazilCorrespondence: Gabriel Pokorny, Tel/Fax +55 11971652026, Email ghpokorny@gmail.comIntroduction: The brain tumor is frequently related to severe motor impairment and impacts the quality of life. The corticospinal tract can sometimes be affected depending on the type and size of the neoplasm, so different tools can evaluate motor function and connections. It is essential to organize surgical procedures and plan the approach. Functional motor status is mapped before, during, and after surgery. Studying corticospinal tract status can help map the functional areas, predict postoperative outcomes, and help the decision, reducing neurological deficits, aiming to preserve functional networks, using the concepts of white matters localization and fibbers connections. Nowadays, there are new techniques that provide functional information regarding the motor cortex, such as transcranial magnetic stimulation (TMS), direct cortical stimulation (DCS), and navigated TMS (nTMS). These tools can be used to plan a customized surgical strategy and the role of motor evoked potentials (MEPs) is well described during intra-operative, using intraoperative neuromonitoring. MEPs can help to localize primary motor areas and delineate the cut-off point of resection in real-time, using direct stimulation. In the post-operative, the MEP has increased your function as a predictive marker of permanent or transitory neurological lesion marker.Methods: Systematic review performed in MEDLINE via PUBMED, EMBASE, and SCOPUS databases regarding the post-operative assessment of MEP in patients with brain tumors. The search strategy included the following terms: ((“Evoked Potentials, Motor”[Mesh]) AND “Neoplasms”[Mesh]) AND “Transcranial Magnetic Stimulation”[Mesh] AND “Brain Tumor”[Mesh]), the analysis followed the PRISMA guidelines for systematic reviews, the review spanned until 06/04/2021, inclusion criteria were studies presenting confirmed diagnosis of brain tumor (primary or metastatic), patients > 18 y/o, using TMS, Navigated TMS, and/or Evoked Potentials as tools in preoperative planning or at the intra-operative helping the evaluation of the neurological status of the motor cortex, articles published in peer-reviewed journals, and written in English or Portuguese.Results: A total of 38 studies were selected for this review, of which 14 investigated the potential of nTMS to predict the occurrence of motor deficits, while 25 of the articles investigated the capabilities of the nTMS technique in performing pre/intraoperative neuro mapping of the motor cortex.Conclusion: Further studies regarding motor function assessment are needed and standardized protocols for MEPs also need to be defined.Keywords: brain tumors, transcranial magnetic resonance, systematic review, neurophysiology, motor cortex mappinghttps://www.dovepress.com/assessing-the-capabilities-of-transcranial-magnetic-stimulation-tms-to-peer-reviewed-fulltext-article-NDTbrain tumorstranscranial magnetic resonancesystematic reviewneurophysiologymotor cortex mapping |
| spellingShingle | Schiavao LJV Neville Ribeiro I Yukie Hayashi C Gadelha Figueiredo E Russowsky Brunoni A Jacobsen Teixeira M Pokorny G Silva Paiva W Assessing the Capabilities of Transcranial Magnetic Stimulation (TMS) to Aid in the Removal of Brain Tumors Affecting the Motor Cortex: A Systematic Review Neuropsychiatric Disease and Treatment brain tumors transcranial magnetic resonance systematic review neurophysiology motor cortex mapping |
| title | Assessing the Capabilities of Transcranial Magnetic Stimulation (TMS) to Aid in the Removal of Brain Tumors Affecting the Motor Cortex: A Systematic Review |
| title_full | Assessing the Capabilities of Transcranial Magnetic Stimulation (TMS) to Aid in the Removal of Brain Tumors Affecting the Motor Cortex: A Systematic Review |
| title_fullStr | Assessing the Capabilities of Transcranial Magnetic Stimulation (TMS) to Aid in the Removal of Brain Tumors Affecting the Motor Cortex: A Systematic Review |
| title_full_unstemmed | Assessing the Capabilities of Transcranial Magnetic Stimulation (TMS) to Aid in the Removal of Brain Tumors Affecting the Motor Cortex: A Systematic Review |
| title_short | Assessing the Capabilities of Transcranial Magnetic Stimulation (TMS) to Aid in the Removal of Brain Tumors Affecting the Motor Cortex: A Systematic Review |
| title_sort | assessing the capabilities of transcranial magnetic stimulation tms to aid in the removal of brain tumors affecting the motor cortex a systematic review |
| topic | brain tumors transcranial magnetic resonance systematic review neurophysiology motor cortex mapping |
| url | https://www.dovepress.com/assessing-the-capabilities-of-transcranial-magnetic-stimulation-tms-to-peer-reviewed-fulltext-article-NDT |
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