A Comparison of the Fifth World Health Organization and the International Consensus Classifications of Mature T-Cell Lymphomas
Peripheral T-cell lymphomas (PTCLs) are a rare subset of non-Hodgkin lymphomas that often carry significant difficulty in diagnosis and classification because of their rarity and biological complexity. Previous editions of the World Health Organization (WHO) classifications of hemopoietic neoplasms...
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/14170 |
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| author | Pier Paolo Piccaluga Shaimaa S. Khattab |
| author_facet | Pier Paolo Piccaluga Shaimaa S. Khattab |
| author_sort | Pier Paolo Piccaluga |
| collection | DOAJ |
| description | Peripheral T-cell lymphomas (PTCLs) are a rare subset of non-Hodgkin lymphomas that often carry significant difficulty in diagnosis and classification because of their rarity and biological complexity. Previous editions of the World Health Organization (WHO) classifications of hemopoietic neoplasms in 2001, 2008, and 2017 aimed to standardize hemopoietic neoplasm diagnosis in general. Since then, crucial clinico-pathological, immunophenotypic, and recent molecular discoveries have been made in the field of lymphomas, contributing to refining diagnostic criteria of several diseases, upgrading entities previously defined as provisional, and identifying new entities. In 2022, two different models were proposed to classify hematolymphoid neoplasms: the 5th edition of the WHO classification (WHO-HAEM5) and the International Consensus Classification (ICC). Of note, a common nosography is mandatory to ensure progress in health science and ensure the basis for a real precision medicine. In this article, the authors summarized the main differences with the previous fourth WHO edition and reviewed the main discrepancies between the two newest classifications, as far as PTCLs are concerned. |
| first_indexed | 2024-03-10T22:39:46Z |
| format | Article |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:39:46Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e4d8b4e9e8e74fa3848e2fd99b5c28052023-11-19T11:08:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181417010.3390/ijms241814170A Comparison of the Fifth World Health Organization and the International Consensus Classifications of Mature T-Cell LymphomasPier Paolo Piccaluga0Shaimaa S. Khattab1Biobank of Research, IRCCS Azienda Opedaliera-Universitaria di Bologna, 40138 Bologna, ItalyMedical Research Institute, Hematology Department, Alexandria University, Alexandria 5310002, EgyptPeripheral T-cell lymphomas (PTCLs) are a rare subset of non-Hodgkin lymphomas that often carry significant difficulty in diagnosis and classification because of their rarity and biological complexity. Previous editions of the World Health Organization (WHO) classifications of hemopoietic neoplasms in 2001, 2008, and 2017 aimed to standardize hemopoietic neoplasm diagnosis in general. Since then, crucial clinico-pathological, immunophenotypic, and recent molecular discoveries have been made in the field of lymphomas, contributing to refining diagnostic criteria of several diseases, upgrading entities previously defined as provisional, and identifying new entities. In 2022, two different models were proposed to classify hematolymphoid neoplasms: the 5th edition of the WHO classification (WHO-HAEM5) and the International Consensus Classification (ICC). Of note, a common nosography is mandatory to ensure progress in health science and ensure the basis for a real precision medicine. In this article, the authors summarized the main differences with the previous fourth WHO edition and reviewed the main discrepancies between the two newest classifications, as far as PTCLs are concerned.https://www.mdpi.com/1422-0067/24/18/14170World Health Organization classificationInternational Consensus ClassificationT-cell lymphomaT-follicular helpergene expression profileimmunophenotype |
| spellingShingle | Pier Paolo Piccaluga Shaimaa S. Khattab A Comparison of the Fifth World Health Organization and the International Consensus Classifications of Mature T-Cell Lymphomas International Journal of Molecular Sciences World Health Organization classification International Consensus Classification T-cell lymphoma T-follicular helper gene expression profile immunophenotype |
| title | A Comparison of the Fifth World Health Organization and the International Consensus Classifications of Mature T-Cell Lymphomas |
| title_full | A Comparison of the Fifth World Health Organization and the International Consensus Classifications of Mature T-Cell Lymphomas |
| title_fullStr | A Comparison of the Fifth World Health Organization and the International Consensus Classifications of Mature T-Cell Lymphomas |
| title_full_unstemmed | A Comparison of the Fifth World Health Organization and the International Consensus Classifications of Mature T-Cell Lymphomas |
| title_short | A Comparison of the Fifth World Health Organization and the International Consensus Classifications of Mature T-Cell Lymphomas |
| title_sort | comparison of the fifth world health organization and the international consensus classifications of mature t cell lymphomas |
| topic | World Health Organization classification International Consensus Classification T-cell lymphoma T-follicular helper gene expression profile immunophenotype |
| url | https://www.mdpi.com/1422-0067/24/18/14170 |
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