Complement-mediated serum bactericidal activity of antibodies elicited by the Shigella sonnei GMMA vaccine in adults from a shigellosis-endemic country: Exploratory analysis of a Phase 2a randomized study

Complement-mediated serum bactericidal activity of antibodies elicited by the Shigella sonnei GMMA vaccine in adults from a shigellosis-endemic country: Exploratory analysis of a Phase 2a randomized study

Shigella is associated with a significant burden of disease worldwide among individuals of all ages and is the major cause of moderate and severe diarrhea in children under five years of age in low- and middle-income countries. Several candidate vaccines against Shigella species are currently under...

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Bibliographic Details
Main Authors: Melissa C. Kapulu, Usman Nakakana, Antonella S. Sciré, Eleanna Sarakinou, Valentino Conti, Omar Rossi, Alessandra Acquaviva, Francesca Necchi, Christina W. Obiero, Laura B. Martin, Philip Bejon, Patricia Njuguna, Francesca Micoli, Audino Podda
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
shigella sonnei
generalized modules for membrane antigens (GMMA)
1790GAHB vaccine
functional antibody
serum bactericidal activity
IgG
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.971866/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.971866/full

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