Fluoxetine modifies circadian rhythm by reducing melatonin content in zebrafish
Fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI), increases the serotonin levels in the brain to treat depression. Antidepressants have been demonstrated to modulate circadian rhythm, but the underlying mechanisms by which antidepressants regulate circadian rhythm require more resea...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222006576 |
| _version_ | 1811337922926870528 |
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| author | Mei-li Wei Shi-min He An-qi Chen Zi-xuan Fan Wei Liu Ling Zhang Shi-jie Lv Cheng-zeng Qiu Hui-ru Liu Mu-xian Hao Zong-jun Yin Da-long Ren |
| author_facet | Mei-li Wei Shi-min He An-qi Chen Zi-xuan Fan Wei Liu Ling Zhang Shi-jie Lv Cheng-zeng Qiu Hui-ru Liu Mu-xian Hao Zong-jun Yin Da-long Ren |
| author_sort | Mei-li Wei |
| collection | DOAJ |
| description | Fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI), increases the serotonin levels in the brain to treat depression. Antidepressants have been demonstrated to modulate circadian rhythm, but the underlying mechanisms by which antidepressants regulate circadian rhythm require more research. This study aimed to investigate the role of FLX on circadian rhythm by analyzing the movement behavior and internal circadian oscillations in zebrafish. The results showed that the expression of clock genes clock1a and bmal1b was significantly down-regulated, and the amplitude reduction and phase shift were observed after FLX treatment. Furthermore, FLX exposure inhibited the expression of aanat2, which led to a decrease in nocturnal melatonin secretion. aanat2-/- larvae showed disrupted circadian rhythm. These findings may help reveal the effect of FLX exposure on the circadian rhythm and locomotor activity. It may provide theoretical data for the clinical application of FLX. |
| first_indexed | 2024-04-13T18:03:04Z |
| format | Article |
| id | doaj.art-e4da90577aa34a3eada52cc0c79b0dad |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-13T18:03:04Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-e4da90577aa34a3eada52cc0c79b0dad2022-12-22T02:36:12ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-09-01153113268Fluoxetine modifies circadian rhythm by reducing melatonin content in zebrafishMei-li Wei0Shi-min He1An-qi Chen2Zi-xuan Fan3Wei Liu4Ling Zhang5Shi-jie Lv6Cheng-zeng Qiu7Hui-ru Liu8Mu-xian Hao9Zong-jun Yin10Da-long Ren11Anhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China; School of Life Science, Anhui Province Key Laboratory of Translational Cancer Research, Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui Province 233030, ChinaAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, ChinaAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, ChinaAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, ChinaAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, ChinaAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, ChinaAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, ChinaAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, ChinaAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, ChinaAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, ChinaAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China; Corresponding authors.Anhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China; Corresponding authors.Fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI), increases the serotonin levels in the brain to treat depression. Antidepressants have been demonstrated to modulate circadian rhythm, but the underlying mechanisms by which antidepressants regulate circadian rhythm require more research. This study aimed to investigate the role of FLX on circadian rhythm by analyzing the movement behavior and internal circadian oscillations in zebrafish. The results showed that the expression of clock genes clock1a and bmal1b was significantly down-regulated, and the amplitude reduction and phase shift were observed after FLX treatment. Furthermore, FLX exposure inhibited the expression of aanat2, which led to a decrease in nocturnal melatonin secretion. aanat2-/- larvae showed disrupted circadian rhythm. These findings may help reveal the effect of FLX exposure on the circadian rhythm and locomotor activity. It may provide theoretical data for the clinical application of FLX.http://www.sciencedirect.com/science/article/pii/S0753332222006576FluoxetineCircadian rhythmsMelatoninBehaviorZebrafish |
| spellingShingle | Mei-li Wei Shi-min He An-qi Chen Zi-xuan Fan Wei Liu Ling Zhang Shi-jie Lv Cheng-zeng Qiu Hui-ru Liu Mu-xian Hao Zong-jun Yin Da-long Ren Fluoxetine modifies circadian rhythm by reducing melatonin content in zebrafish Biomedicine & Pharmacotherapy Fluoxetine Circadian rhythms Melatonin Behavior Zebrafish |
| title | Fluoxetine modifies circadian rhythm by reducing melatonin content in zebrafish |
| title_full | Fluoxetine modifies circadian rhythm by reducing melatonin content in zebrafish |
| title_fullStr | Fluoxetine modifies circadian rhythm by reducing melatonin content in zebrafish |
| title_full_unstemmed | Fluoxetine modifies circadian rhythm by reducing melatonin content in zebrafish |
| title_short | Fluoxetine modifies circadian rhythm by reducing melatonin content in zebrafish |
| title_sort | fluoxetine modifies circadian rhythm by reducing melatonin content in zebrafish |
| topic | Fluoxetine Circadian rhythms Melatonin Behavior Zebrafish |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222006576 |
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