Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.
<h4>Background</h4>Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284705/pdf/?tool=EBI |
| _version_ | 1818574630662701056 |
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| author | Carolina Barragán-Martínez Cesar A Speck-Hernández Gladis Montoya-Ortiz Rubén D Mantilla Juan-Manuel Anaya Adriana Rojas-Villarraga |
| author_facet | Carolina Barragán-Martínez Cesar A Speck-Hernández Gladis Montoya-Ortiz Rubén D Mantilla Juan-Manuel Anaya Adriana Rojas-Villarraga |
| author_sort | Carolina Barragán-Martínez |
| collection | DOAJ |
| description | <h4>Background</h4>Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs.<h4>Methods and findings</h4>The systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95% CI: 1.25-1.92; p-value<0.001).<h4>Conclusion</h4>Exposure to OSs is a risk factor for developing ADs. As a corollary, individuals with non-modifiable risk factors (i.e., familial autoimmunity or carrying genetic factors) should avoid any exposure to OSs in order to avoid increasing their risk of ADs. |
| first_indexed | 2024-12-15T00:29:06Z |
| format | Article |
| id | doaj.art-e4decee6653e49ae8a56d567e25bba46 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-15T00:29:06Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e4decee6653e49ae8a56d567e25bba462022-12-21T22:42:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5150610.1371/journal.pone.0051506Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.Carolina Barragán-MartínezCesar A Speck-HernándezGladis Montoya-OrtizRubén D MantillaJuan-Manuel AnayaAdriana Rojas-Villarraga<h4>Background</h4>Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs.<h4>Methods and findings</h4>The systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95% CI: 1.25-1.92; p-value<0.001).<h4>Conclusion</h4>Exposure to OSs is a risk factor for developing ADs. As a corollary, individuals with non-modifiable risk factors (i.e., familial autoimmunity or carrying genetic factors) should avoid any exposure to OSs in order to avoid increasing their risk of ADs.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284705/pdf/?tool=EBI |
| spellingShingle | Carolina Barragán-Martínez Cesar A Speck-Hernández Gladis Montoya-Ortiz Rubén D Mantilla Juan-Manuel Anaya Adriana Rojas-Villarraga Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis. PLoS ONE |
| title | Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis. |
| title_full | Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis. |
| title_fullStr | Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis. |
| title_full_unstemmed | Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis. |
| title_short | Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis. |
| title_sort | organic solvents as risk factor for autoimmune diseases a systematic review and meta analysis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284705/pdf/?tool=EBI |
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