A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis.

A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis.

Fibroblast growth factor-1 (FGF1) and FGF2 play a critical role in angiogenesis, a formation of new blood vessels from existing blood vessels. Integrins are critically involved in FGF signaling through crosstalk. We previously reported that FGF1 directly binds to integrin αvβ3 and induces FGF recept...

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Main Authors: Seiji Mori, Vu Tran, Kyoko Nishikawa, Teruya Kaneda, Yoshinosuke Hamada, Naomasa Kawaguchi, Masaaki Fujita, Jun Saegusa, Yoko K Takada, Nariaki Matsuura, Min Zhao, Yoshikazu Takada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3585250?pdf=render

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